Conserved Protein Domain Family
NTP-PPase_COG4997
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cd11532: NTP-PPase_COG4997 
Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria
The family includes some uncharacterized hypothetical proteins from archaea and bacteria. Although their biological roles remain unclear, the family members show significant sequence similarity to the dimeric 2-deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTP pyrophosphatase or dUTPase) and NTP-PPase MazG proteins. However, unlike typical tandem-domain MazG proteins, the family contains a single MazG-like domain.
Links
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Statistics
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PSSM-Id: 212139
Aligned: 70 rows
Threshold Bit Score: 62.1755
Created: 30-Aug-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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metal binding
Feature 1: metal binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:E E E DClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on sequence similarity to other superfamily members.
  • Comment:Most members of the NTP-PPase superfamily contain the well-conserved divalent ion-binding motif, EEED.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                #  #                   #  #             
NP_633958      8 GHKAIRDRIPDILRDSGRdfavkeISDPEFLLELERKLEEELAEYLESK-----------EAEELADLLEVIYRIAELRG 76   Methanosarcina...
BAI93619       5 YYKLVRDRIPETIRQSGGkpeikvLSEAEYRIALRNKLREEAEEVQESDda--------sLLEELADILEVVESLRKSYN 76   Arthrospira pl...
YP_002373149   5 HHKLVRDKIPDIIAKSENfceirtLSEQEYLEALKHKLLEEAQEVIEADpe--------nLVKELGDLFEVIDNILIAYQ 76   Cyanothece sp....
CBE67513     659 YNKIVRDKIPEIIAKRGErakiihLRGDALVTALRQKLVEEAFEAVDARsg-------ddLVGELADVSEVIDALCRALK 731  NC10 bacterium...
YP_004781922   2 CWKLVRDKIGEELRSRGVtvw-kaRSNEEYVNALRAKIIEEAYELAVAEss-------esVLEEAADLLEAIVSLLKLHG 73   Pyrolobus fuma...
YP_001435298   2 GGKLVRDKIPTVAPGAYVk-----CDGSERLEWLKKKLVEEALEFLIEP-----------SVEELADVLEVVKALIDVFG 65   Ignicoccus hos...
YP_002229344 652 FHKLVRDGVPRKITSGGEaakivrLSGDDFLHALREKLVEEAIEALDARgh-------dkLLEELADVEEVIDGILRQLK 724  Burkholderia c...
ZP_08575586    1 MKKLVRDKIPSILADDAEfe---vLSNEDYRLSLRHKIVEEAKEVQNAQsr-------anLVEELGDLEEVIRAILTDAS 70   Lactobacillus ...
YP_003198407  12 YHKLVRDKIPSIIRDNDHqptvlsLSGQDLTQAASQKLLEEAYELFTEVqvge----kpsVLKESADVLEVVLTILKQLG 87   Desulfohalobiu...
EES51828      16 REKLVRDRIPESVSQGPPr----tLGSRERASFLAAKVVEEAAELAEQIlhvaeggvsdgVLLEMADLLEVLDRVRSVFS 91   Leptospirillum...

Feature 1                               
NP_633958     77 fskEALESVRLKKRKESGGFEKN 99   Methanosarcina mazei Go1
BAI93619      77 isdEQIQLKVDEKRAQRGGFEQK 99   Arthrospira platensis NIES-39
YP_002373149  77 isrETVINYQQQRRKERGGFTQR 99   Cyanothece sp. PCC 8801
CBE67513     732 vsdPHLKAVQLEKRQKRGGFEKG 754  NC10 bacterium 'Dutch sediment'
YP_004781922  74 ytlEDLLARAEAKRRERGGFEKR 96   Pyrolobus fumarii 1A
YP_001435298  66 ---DEVYKVAESKRKELGGFEEC 85   Ignicoccus hospitalis KIN4/I
YP_002229344 725 isrTELNRLKKQKHAQSGGFEEG 747  Burkholderia cenocepacia J2315
ZP_08575586   71 inyEEMDSLRQAKINQKGNFSQK 93   Lactobacillus farciminis KCTC 3681
YP_003198407  88 ysfDDLISEMELRREQRGGFEQG 110  Desulfohalobium retbaense DSM 5692
EES51828      92 lspTQVKKTRKEKLRIRGGFESD 114  Leptospirillum ferrodiazotrophum

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