Conserved Protein Domain Family
SLC6sbd_SIT1
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cd11518: SLC6sbd_SIT1 
Na(+)- and Cl(-)-dependent imino acid transporter SIT1; solute-binding domain
SIT1 (also called XTRP3, XT3, IMINO) transports imino acids, such as proline, pipecolate, MeAIB, and sarcosine. It has weak affinity for neutral amino acids such as phenylalanine. Human SIT1 is encoded by the SLC6A20 gene. SIT1 is expressed in brain, kidney, small intestine, thymus, spleen, ovary, and lung. SLC6A20 is a candidate gene for the rare disorder iminoglycinuria. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.
Links
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Statistics
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PSSM-Id: 271401
Aligned: 3 rows
Threshold Bit Score: 1094.62
Created: 8-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:Na binding site 2 [ion binding site]
Evidence:
  • Comment:based on Aquifex aeolicus LeuT (SLC6) with structure
  • Comment:One of two Na+ binding sites in Aquifex aeolicus LeuT. It binds the Na+ ion designated Na2, and appears conserved in Vibrio parahaemolyticus vSGLT and other SLC5 proteins
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                          #  #                                                          
Q9NP91         2 EKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQRMRQGSIGAWRTIS 81  human
XP_003225803   4 EKSRPLWDNPFQFVLACISYAVGLGNVWRFPYLCQMHGGGGFLIPYLIMLILEGMPLLYLELAVGQHMRQGSIGAWKAIS 83  green anole
XP_002942571   2 EKTRPVWDNPLQFVFACISYAVGLGNVWRFPYLCQMYGGGGFLIPYLIMLILEGMPLLYLELTVGQLLRQGSIGAWKSIS 81  western clawed ...

Feature 1                                                                                        
Q9NP91        82 PYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVCPLNGNHTgYDEECEKASSTQYFWYRKTLNISPSLQ 161 human
XP_003225803  84 PYLCGVGVASVIVSFFLSMYYNVINAWAFWYLFHSFQDPLPWANCPLNSNHTdYVEECEKATPTQYFWYRKTLNISPSIE 163 green anole
XP_002942571  82 PYLGGVGIASMVVSFFLCIYYNVINAWAFWYLFHSFQEPLPWSNCPVNSNLSaYNEECERSSPTQYFWYRETMNISPSIL 161 western clawed ...

Feature 1                                                                                        
Q9NP91       162 eNGGVQWEPALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANPKAW 241 human
XP_003225803 164 eNGGLQWEQAACLILAWLVVYLCILRGTEHTGKVVYVTATMPYVVLTIYLIRGLTLHGAANGLTYMFTPKLEELANPKTW 243 green anole
XP_002942571 162 qSGEIQWELAVCLILSWFVVYLCILRGTESTGKVVYVTALIPYLVLLIYLGRGLTLHGAANGLAFMFTPKLEQLANLKTW 241 western clawed ...

Feature 1                                                                                        
Q9NP91       242 INAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKATFNYENCLkkvsLLLTNTF 321 human
XP_003225803 244 INAATQIFFSLGLGFGSLIAFASYNEPSNNCERHAIIVSLINSSTSVFASIVTFSIYGFKATFNYENCIkkviLLMTNFF 323 green anole
XP_002942571 242 INAATQIFFSLGLGFGSLIAFASYNEPNNNCERHAIIVSLINSGTSIFASIVTFSIYGFKATFNYENCMsrdiLLLTNTF 321 western clawed ...

Feature 1                                                                                        
Q9NP91       322 DLEDGFLtasNLEQVKgyLASAYPSKYSEMfpqIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLM 401 human
XP_003225803 324 DLEEGLItmeNLDDMKhfLASAHPREYADLlpqIKNCSLEAELDTAVQGTGLAFIVYSEAIKNMEVSQLYSVLYFIMLLM 403 green anole
XP_002942571 322 DLEEGSVtteNLGDMKnyLNATFHQEYSSIvplLKNCSLEKELSTAVQGTGLAFIVYTEAIKNMEVSQLWSVMYFLMLLM 401 western clawed ...

Feature 1        #  ##                                                                           
Q9NP91       402 LGIGSMLGNTAAILTPLTDSKIISsHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVC 481 human
XP_003225803 404 LGIGSMLGNTAAILTPLTDSKFISsHVPREMISGGICIINCFVGLLFTMQAGNYWFDIFNDYAATLSLLLIVLVETIAVC 483 green anole
XP_002942571 402 LGLGSMLGSTAAIITPLTDSKFISkHLPKEAVSGLLCFTCCIIGLVFTLESGSYWFDIFNDYSVTLSLLLIVFAEIIGVC 481 western clawed ...

Feature 1                                                                                        
Q9NP91       482 YVYGLRRFeSDLKAMTGRAVsWYWKVMWAGVSPLLIVSLFVFYLSDYIlTGTLKYQAWDASQGQLVTKDYPAYALAVIGL 561 human
XP_003225803 484 YVYGLRRFqKALGAMIGHEPsWYWKIMWAFVSPVLIVSLFIFYLTDYIrTGTLRYQAWDATEGQLVTKDYPSGALAVIGL 563 green anole
XP_002942571 482 YVYGLSRFeNDIEMMTGHKLsWYWKIMWGFTSPLLIISLFIFYLTDYImAGTLQYKAWDATLGQLVTKDYPPYALAVIGL 561 western clawed ...

Feature 1                        
Q9NP91       562 LVASSTMCIPLAALGT 577 human
XP_003225803 564 LVAASTLCIPLGAIVI 579 green anole
XP_002942571 562 LLVAPVCCITVVAIVN 577 western clawed frog

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