Conserved Protein Domain Family
SLC6sbd_B0AT1
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cd11516: SLC6sbd_B0AT1 
Na(+)-dependent neutral amino acids transporter, B0AT1; solute-binding domain
B0AT1 (also called HND) transports neutral amino acids. Human B0AT1 is encoded by the SLC6A19 gene. B0AT1 is expressed primarily in the kidney and intestine; it requires collectrin for expression in the kidney, and angiotensin-converting enzyme 2 for expression in the intestine. Interaction with these two proteins implicates B0AT1 in more complex processes such as glomerular structure, exocytosis, and blood pressure control. The autosomal recessive disorder, Hartnup disorder, is caused by mutations in B0AT1. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.
Links
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Statistics
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PSSM-Id: 212085
Aligned: 5 rows
Threshold Bit Score: 1119.59
Created: 8-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:Na binding site 2 [ion binding site]
Evidence:
  • Comment:based on Aquifex aeolicus LeuT (SLC6) with structure
  • Comment:One of two Na+ binding sites in Aquifex aeolicus LeuT. It binds the Na+ ion designated Na2, and appears conserved in Vibrio parahaemolyticus vSGLT and other SLC5 proteins
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       #  #                                                             
Q695T7        32 RPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPAL 111 human
NP_956030     33 RPKWDNKAQYMLTCVGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVFEGIPLLHLEFAIGQRLRKGSVGVWRTINPYM 112 zebrafish
XP_419056     32 RPKWDNKAQYMLTCVGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLILEGIPLLHLEFAIGQRLRRGSVGVWSSIHPTL 111 chicken
NP_001087680  32 RPQWDNKAQYMLTCIGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVFEGIPLLHLEFAIGQRLRKGSVGVWSTIHPTL 111 African clawed ...
AAI54320      33 RPKWDNKAQYMLTCVGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVFEGIPLLHLEFAIGQRLRKGSVGVWRTINPYM 112 zebrafish

Feature 1                                                                                        
Q695T7       112 KGLGLASMLTSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDCPLNENQTgyVDECARSSPVDYFWYRETLNISTSISDSG 191 human
NP_956030    113 LGVGIASMCVSFLVSLYYNTIIAWVMWYFFNSFQDPLPWSQCPINENRTgpIPECGKSSPVDYFWYRETLNTSAAIDDTG 192 zebrafish
XP_419056    112 KGVGIAAMCVSFLVSLYYNTIIAWVMWYFFNSFQEPLPWSTCPLIDNRTdyIEECAKSSPVDYFWYRETLNTSTSIEDSG 191 chicken
NP_001087680 112 KGVGIASMLVSFLVGLYYNTIIAWVMWYFFNSFQEPLPWSFCPLTANRTeyVSECARSSSVDYFWYRETLNVSTKIDDSG 191 African clawed ...
AAI54320     113 LGVGIASMCVSFLVSLYYNTIIAWVMWYFFNSFQDPLPWSQCPINENRTgpIPECGKSSPVDYFWYRETLNTSAAIDDTG 192 zebrafish

Feature 1                                                                                        
Q695T7       192 SIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELAQPDTWLDA 271 human
NP_956030    193 GLQVWMVLCLISAWAVLYVCCIRGIETTGKAVYVTSTLPYLVLTIFLIRGLTLKGSVDGIKFLFTPDINELANPSTWLDA 272 zebrafish
XP_419056    192 TIQWWLLLCLTCAWGILYVCTIRGIETTGKAVYITSTLPYLVLTIFLIRGLTLKGSVNGIVFLFTPNVAELANPVTWLDA 271 chicken
NP_001087680 192 NIQWWLVLCLACAWGVLYVCTIRGIETTGKAVYVTSTLPYVVLTIFLIRGLTLKGSVNGIKFLFTPDISELANPVTWLDA 271 African clawed ...
AAI54320     193 GLQVWMVLCLISAWAVLYVCCIRGIETTGKAVYVTSTLPYLVLTIFLIRGLTLKGSVDGIKFLFTPDINELANPSTWLDA 272 zebrafish

Feature 1                                                                                        
Q695T7       272 GAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFRATqRYDDCFSTNILTLINGFDLP 351 human
NP_956030    273 GAQVFYSFSLAFGGLISFSSYNSVHNNCEQDAVIISVINAFTSIYAATVIYSIIGFRATeRFDDCMNGNILTLLNTFDLP 352 zebrafish
XP_419056    272 GAQVFYSFSLAFGGLISFSSYNPVHNNCEKDAVIISVINGFTSIYAATVIYSIIGFRATeRYDDCFDKNILTLINAFDLP 351 chicken
NP_001087680 272 GAQVFYSFSLAFGGLISFSSYNSVHNNCEKDAVIISLINGFTSIYSATVIYSIIGFRATaRFDDCFDSNVLSLTNAFDLP 351 African clawed ...
AAI54320     273 GAQVFYSFSLAFGGLISFSSYNSVHNNCEQDAVIISVINAFTSIYAATVIYSIIGFRATeRFDDCMNGNILTLLNTFDLP 352 zebrafish

Feature 1                                                                                   #  ##
Q695T7       352 EGNVTQENFVDmqqrCNASDPAAYAQLvFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSS 431 human
NP_956030    353 EGFINQSNYQDvfqsLNSTSPDIISSLsLKTCDLNNFLSEGVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSS 432 zebrafish
XP_419056    352 EGNVTQDNFEQmqqlCNMTDPVTFASLnFETCDLKSFLSEGVEGTGLAFIVFTEAITKMPVSPLWSILFFIMLFCLGLSS 431 chicken
NP_001087680 352 EGNITQDNYDNmlnqLNHSNPDLISSLkLQTCDLNQILSDGVEGTGLAFIVFTEAITKMPISPLWSVLFFIMLFCLGLSS 431 African clawed ...
AAI54320     353 EGFINQSNYQDvfqsLNSTSPDIISSLsLKTCDLNNFLSEGVEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFCLGLSS 432 zebrafish

Feature 1                                                                                        
Q695T7       432 MFGNMEGVVVPLQDLRVIPpKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGV 511 human
NP_956030    433 MFGNIEGVLVPLQDLGVFPkSWPKEIISGVTCLVCCLVGLIFVQGSGNYWLALFDSFAGSIPLLIIAFSEMIGVVYVYGI 512 zebrafish
XP_419056    432 MFGNVEGVLVPLQDLKVVPpKWPKELITGIVCAGSYLIAFIFVLRSGNYWLALFDSFAGSIPLLIIAFCEMFSVVYIYGI 511 chicken
NP_001087680 432 MFGNMEGVLVPLLDLKIIPkSVPKEAVTGLICAVSFLIALIFVLESGNYWLALFDGFAGSIPLLIIAFCEMFSVVYIYGV 511 African clawed ...
AAI54320     433 MFGNIEGVLVPLQDLGVFPkSWPKEIISGVTCLVCCLVGLIFVQGSGNYWLALFDSFAGSIPLLIIAFSEMIGVVYVYGI 512 zebrafish

Feature 1                                                                                        
Q695T7       512 DRFnKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAG 591 human
NP_956030    513 DRFnEDLIFMIGHKPNIFWQATWRFISPLIMLAIFVFYFSTTVTKEIFYSAWDPESENFPTLEKKPYPTWIYVIIFLLAG 592 zebrafish
XP_419056    512 DRFnKDIEFMIGHKPNIFWQVTWRVISPLIMLVIFLFYFVVKVNEELLYSVWNPKYEEFPKPQKIGYPGWVYAIIVIIAG 591 chicken
NP_001087680 512 DRFnRDIQFMIGHKPNIFWQATWRVISPLIMLVIFLFYFVVKVSQKLEYITWDPDYDQFPKSKPESYPSWIYAIIVILAG 591 African clawed ...
AAI54320     513 DRFnEDLIFMIGHKPNIFWQATWRFISPLIMLAIFVFYFSTIVTKEIFYSAWDPESENFPTLEKKPYPTWIYVIIFLLAG 592 zebrafish

Feature 1                             
Q695T7       592 VPSLTIPGYAIYKLIRNHCQK 612 human
NP_956030    593 VPSLAVPGTAVFRAIRDYCCK 613 zebrafish
XP_419056    592 VPSLIIPVFAIYKAIRNCCQK 612 chicken
NP_001087680 592 VPSLVIPGYAIYKLIRNCCTK 612 African clawed frog
AAI54320     593 VPSLAVPGTAVFRAIRDYCCK 613 zebrafish

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