Conserved Protein Domain Family
SLC6sbd_NTT4-like
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cd11515: SLC6sbd_NTT4-like 
Na(+)-dependent neurotransmitter transporter 4, and related proteins; solute-binding domain
This subgroup includes the solute-binding domain of NTT4 (also called XT1) and SBAT1 (also called B0AT2, v7-3, NTT7-3); both these proteins can transport neutral amino acids. Human SBAT1 is encoded by the SLC6A15 gene, a susceptibility gene for major depression. SBAT1 is expressed in brain, and may have a role in transporting neurotransmitter precursors into neurons. Human NTT4 is encoded by the SLC6A17 gene. NTT4 is specifically expressed in the nervous system, in synaptic vesicles of glutamatergic and GABAergic neurons, and may play an important role in synaptic transmission. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.
Links
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Statistics
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PSSM-Id: 271400
Aligned: 3 rows
Threshold Bit Score: 1047.61
Created: 8-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:Na binding site 2 [ion binding site]
Evidence:
  • Comment:based on Aquifex aeolicus LeuT (SLC6) with structure
  • Comment:One of two Na+ binding sites in Aquifex aeolicus LeuT. It binds the Na+ ion designated Na2, and appears conserved in Vibrio parahaemolyticus vSGLT and other SLC5 proteins
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    #  #                                                             
Q9H1V8     60 RPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWHYICPRL 139 human
Q9H2J7     61 RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELSVGQRIRRGSIGVWNYISPKL 140 human
Q9XS59     61 RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLLVIGIPLFFLELSVGQRIRRGSIGVWNYISPQL 140 cattle

Feature 1                                                                                     
Q9H1V8    140 GGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWSECPVVRNGSvaVVEAECEKSSATTYFWYREALDISDSISe 219 human
Q9H2J7    141 GGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWDQCPLVKNAShtFVEPECEQSSATTYYWYREALNISSSISe 220 human
Q9XS59    141 GGIGFASCVVCFFVALYYNVIIGWSLFYFSQSFQQPLPWDQCPLVKNAShtFVEPECEKSSATTYYWYREALNISTSISe 220 cattle

Feature 1                                                                                     
Q9H1V8    220 SGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWR 299 human
Q9H2J7    221 SGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWR 300 human
Q9XS59    221 SGGLNWKMTICLLAAWVVVCLAMIKGIQSSGKIMYFSSLFPYVVLICFLIRALLLNGSVDGIRHMFTPELEIMLEPKVWR 300 cattle

Feature 1                                                                                     
Q9H1V8    300 EAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKanimnekcvvenaekilgyln 379 human
Q9H2J7    301 EAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKanvinekcitqnsetimkflk 380 human
Q9XS59    301 EAAAQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSILATLVVFAVLGFKanvinekciaensemiiklvk 380 cattle

Feature 1                                                                                     
Q9H1V8    380 tnvlsrdlipphvnfshlttkdymemynvIMTVKEDQFSalgLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPaSPFWS 459 human
Q9H2J7    381 mgnisqdiiphhinlstvtaedyhlvydiIQKVKEEEFPalhLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPaSPFWS 460 human
Q9XS59    381 mgnisqdiiphhinfsaitaedydliydiIQKVKEEEFPalhLNACQIEDELNKAVQGTGLAFIAFTEAMTHFPaSPFWS 460 cattle

Feature 1              #  ##                                                                  
Q9H1V8    460 VMFFLMLINLGLGSMIGTMAGITTPIIDtFKVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILE 539 human
Q9H2J7    461 VMFFLMLVNLGLGSMFGTIEGIVTPIVDtFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILE 540 human
Q9XS59    461 VMFFLMLVNLGLGSMFGTIEGIITPVVDtFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILE 540 cattle

Feature 1                                                                                     
Q9H1V8    540 NIAVAWIYGTKKFmQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSAWIKEEAAERYLYFPNWAMA 619 human
Q9H2J7    541 NIAVCFVYGIDKFmEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKASEEFLSYPTWGLV 620 human
Q9XS59    541 NIAVSFVYGIDKFmEDLKDMLGFTPNRYYYYMWKYISPLMLLSLLIASIVNMGLSPPGYNAWMEDKASEKFLSYPTWGMV 620 cattle

Feature 1                         
Q9H1V8    620 LLITLIVVATLPIPVVFVLR 639 human
Q9H2J7    621 VCVSLVVFAILPVPVVFIVR 640 human
Q9XS59    621 ICISLMVLAILPIPVVFIIR 640 cattle

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