Conserved Protein Domain Family
SLC6sbd_GAT2
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cd11507: SLC6sbd_GAT2 
Na(+)- and Cl(-)-dependent GABA transporter 2; solute-binding domain
This family includes human GAT2 (hGAT2) which transports gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. hGAT2 is encoded by the SLC6A13 gene, and is similar to mouse GAT-3, and rat GAT2. hGAT2 is expressed in brain, kidney, lung, and testis. hGAT2 is a potential drug target for treatment of epilepsy. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.
Links
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Statistics
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PSSM-Id: 271396
Aligned: 3 rows
Threshold Bit Score: 1075.76
Created: 18-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:Na binding site 2 [ion binding site]
Evidence:
  • Comment:based on Aquifex aeolicus LeuT (SLC6) with structure
  • Comment:One of two Na+ binding sites in Aquifex aeolicus LeuT. It binds the Na+ ion designated Na2, and appears conserved in Vibrio parahaemolyticus vSGLT and other SLC5 proteins
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       #  #                                                             
Q9NSD5        32 RGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQYTSqGGVTAWRKICPIF 111 human
AAH60418      36 RGQWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYTSqGGVTAWRKICPLF 115 African clawed ...
XP_003640448 119 RGQWNNKLEYVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYTSqGGVTAWRRICPLF 198 chicken

Feature 1                                                                                        
Q9NSD5       112 EGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTseNATSPVIEFWERRV 191 human
AAH60418     116 EGIGYASQVIVMLLNCYYVIVLAWALFYLFNSFTSELPWASCGHSWNTENCVDFYKANSTHNVTl-NGTSSVIEFWERRV 194 African clawed ...
XP_003640448 199 EGIGYASQVIVVLLNFYYIVVLAWALFYLFSSFTIDLPWGSCDHEWNTGNCMELQRANSTLNMTseNATSPVIEFWERRV 278 chicken

Feature 1                                                                                        
Q9NSD5       192 LKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNLT 271 human
AAH60418     195 LGISDGIGNIGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLIVLLIRGVSLPGALTGIQFYLYPDLS 274 African clawed ...
XP_003640448 279 LKISDGIQHLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVSLPGASQGILFYLYPDLS 358 chicken

Feature 1                                                                                        
Q9NSD5       272 RLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVA 351 human
AAH60418     275 KLQDPEVWMDAGTQIFFSYAICLGCLTALGSYNKYNNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMAEEQGVHISEVA 354 African clawed ...
XP_003640448 359 RLGDPQVWMDAGTQIFFSYAICLGCLTALGSYNKYHNNCYRDCVALCFLNSGTSFVAGFAIFSILGFMAGEQGVPIAEVA 438 chicken

Feature 1                                          #  ##                                         
Q9NSD5       352 ESGPGLAFIAYPRAVVMLPfSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVG 431 human
AAH60418     355 ESGPGLAFIAYPRAVSMMPfSPLWACFFFFMVILLGLDSQFVCVESLVTAVVDMYPTIFRKKNRRELLILAVSIVSFFVG 434 African clawed ...
XP_003640448 439 ESGPGLAFIAYPRAVVMLPfSPLWACFFFLMVVLLGLDSQFVCVESLVTALVDMYPTIFRKKNRRETLILLVSILSYLVG 518 chicken

Feature 1                                                                                        
Q9NSD5       432 LIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFS 511 human
AAH60418     435 LIMLTEGGMYVFQLFDYYAASGMCLLFVAIFETLCVGWVYGADNFYENVEHMIGYRPTAIIKYCWLFITPAVCMATFLFS 514 African clawed ...
XP_003640448 519 LVMLTEGGMYVFQLFDYYAASGMCLLFVAIFETLCVAWVYGAERFYDNIEDMIGYRPWSIIKYCWLFITPAVCLATFLFS 598 chicken

Feature 1                                                                        
Q9NSD5       512 LIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGpFRERIRQLMCPAEDLP 575 human
AAH60418     515 LVKYTPLNYNKRYVYPWWGDAIGWLLALSSMVCIPLWVGYKLSTIKGsLIERFRQLTCPDPDLP 578 African clawed frog
XP_003640448 599 LIKYTPLTYNKKYVYPWWGDTLGWLLALSSMVCIPLWIIYKLSTIKGsLRERFRQLTCPLEDLP 662 chicken

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