uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain
Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Comment:based on the structures of Vibrio parahaemolyticus vSGLT (SLC5), Aquifex aeolicus LeuT (SLC6), and the NCS1, Microbacterium liquefaciens Mhp1, bound with Na+, functional studies of Escherichia coli PutP (SLC5) and mammalian NIS (SLC5), and mutational analysis of vSGLT
Comment:one of two Na+ binding sites in Aquifex aeolicus LeuT, where it is referred to as the Na binding site 2
Jiyao W et al.(2023). "The conserved domain database in 2023.",