Conserved Protein Domain Family
SLC5sbd_SGLT2
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cd11487: SLC5sbd_SGLT2 
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain
Human SGLT2 (hSGLT2) is a high-capacity, low-affinity glucose transporter, that plays an important role in renal glucose reabsorption. It is encoded by the SLC5A2 gene and expressed almost exclusively in renal proximal tubule cells. Mutations in hSGLT2 cause Familial Renal Glucosuria (FRG), a rare autosomal defect in glucose transport. hSGLT2 is a major drug target for regulating blood glucose levels in diabetes. hSGLT2 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Links
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Statistics
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PSSM-Id: 212056
Aligned: 4 rows
Threshold Bit Score: 1054.13
Created: 18-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1: putative glycosylation site [posttranslational modification site], 1 residue position
Conserved feature residue pattern:NClick to see conserved feature residue pattern help
Evidence:
  • Comment:predicted N-glycosylation site for bovine SGLT2
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
AAL66409      24 ADILVIAAYFLLVIGVGLWSMCRtNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNAL 103 human
NP_998091     15 ADISVIIIYFLVVIAVGIWSTFRtNRGTVGGYFLAGRTMVWWPVGTSLFASNIGSGHFVGLAGTAAASGIAVGGFEWNAL 94  zebrafish
NP_001087699  25 ADISVIVGYFVIVIGVGLWSMRRaNRGTVGGYFLAGRSMSWGPVGASLFASNIGSGHFVGLAGTGAASGIAVAGFEWNAL 104 African clawed ...
AAP43921      24 ADILVIAAYFLLVIGVGLWSMCRtNRGTVGGYFLAGRNMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNAL 103 cattle

Feature 1                                                                                        
AAL66409     104 FVVLLLGWLFAPVYLTAGVITMPQYLRKRFGGrRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLG 183 human
NP_998091     95 FIVLLLGWVFVPVYLTAGVITMPQYLKKRFGGsRISLYLSIISLFLYIFTKISVDMFSGAVFIQQALGWNIYVAVIALLC 174 zebrafish
NP_001087699 105 FVVLVLGWIFVPVYLTAEVVTMPEYLKKRFGGqRIQMYLSVLSLVMYIFTKISVDMFSGAVFIQLALGWNIYLSVIALLV 184 African clawed ...
AAP43921     104 FVVLLLGWLFVPVYLTAGVITMPQYLRKRFGGhRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLG 183 cattle

Feature 1                                                                          #             
AAL66409     184 ITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYsgLFDKYLGAATSltvsedpAVGNISsfCYRPRPDSY 263 human
NP_998091    175 ITALYTVTGGLAALMYTDTVQTFVIIAGAFVLMGFSFYEVGGYsaLLEKYNSSLPSqtlslnpNEYNISqhCYMPREDAF 254 zebrafish
NP_001087699 185 ITTIYTVTGGLAALMYTDTVQTFVIIGGACVLTGYAFEAVGGYdaLMEKYMKAVPT-------VLGNVSesCAAPRADSL 257 African clawed ...
AAP43921     184 ITMIYTVTGGLAALMYTDTVQTFVILAGAFVLMGYAFHEVGGYsgLFDKYLRAVTSltvsedpAVGNISssCYRPRPDSY 263 cattle

Feature 1                                                                                        
AAL66409     264 HLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEV 343 human
NP_998091    255 HLLRDPTTGDLPWPGVIFGIAIIGSWYWCTDQVIVQRCLAARSLTHVKAGCILCGYLKLLPMFLMVFPGMISRVLYPDDV 334 zebrafish
NP_001087699 258 HLLRDPISGDLPWPALILGLTIVSTWYWCSDQVIVQRCLAARSITHVKLGCVLCGYMKILPMFLMVMPGMISRVLFTEEV 337 African clawed ...
AAP43921     264 HLLRDPVTGDLPWPALLLGLTIVSSWYWCSDQVIVQRCLAGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISRVLYPDEV 343 cattle

Feature 1                                                                                        
AAL66409     344 ACVVPEVCRRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELL 423 human
NP_998091    335 GCVEKSVCNKVCGTEVGCSNIAYPKLVVSVMPTGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIWTRIRPQARDKELM 414 zebrafish
NP_001087699 338 ACVEPSRCLAACGTKIGCSNIAYPKLVIELMPNGLRGLMLAVMLAALMSSLASIFNSSGTLFTMDIWRRMRPQAVEKELL 417 African clawed ...
AAP43921     344 ACVVPEVCKRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELL 423 cattle

Feature 1                                                                                        
AAL66409     424 LVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRVNEQGAFWGLIGGLLMGLARLIPE 503 human
NP_998091    415 VVGRVWILCIVGISTCWIPVVQAAQSGQLFDYIQSVTSYLAPPIAAVFFLAIFVKRVNESGAFWGLMGGLVMGLCRMVPE 494 zebrafish
NP_001087699 418 LVGRVWTVCLVALSIAWIPVVQAAQGGQLFDYIQSVASFLAPPIAAVYFLALFVKRVNEPGAFWGLVGGLFLGLCRMVPE 497 African clawed ...
AAP43921     424 LVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVPRVNEKGAFWGLIGGLLMGLARLVPE 503 cattle

Feature 1                                                                                        
AAL66409     504 FSFGSGSCVQPSACPaFLCGVHYLYFAIVLFFCSGLLTLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLdadeqqgssl 583 human
NP_998091    495 FVFGSGSCLKPSNCPkVICGVHYLYFAILLFFCTAILVLFVSYNTPPIKDKHLHRLVFTLRHSTEERVDLdweeeergrk 574 zebrafish
NP_001087699 498 FAFGSGSCSAPSSCPtIICGVHYLYFAIILFLCSGAIVIIVSLCTPPISERKLHRLVYSLRHSQEPREEMeetgvsdpq- 576 African clawed ...
AAP43921     504 FSFGSGSCVRPSGCPaLLCRVHYLYFAILLFVCSGLLTLVVSLCTPPIPRKHLYRLVFSLRHSKEEREDLdaeelegpta 583 cattle

Feature 1                                                                                        
AAL66409     584 pvqngcpesamemngrapcwevgleelssrkltagpqfpsepqapapslfrqcllwfcgmsrggvgspppltqeeaaaaa 663 human
NP_998091    575 arreadekrrakndedqiergeq---------------------------simmkiigwfcgisdtqapepteeevteas 627 zebrafish
NP_001087699 577 --------------------------------------------------------------------------sqekqv 582 African clawed ...
AAP43921     584 apvqngrpehavemeapppprpgl-------------------------lrqcllwfcgvsrggvgspqrptqeettaaa 638 cattle

Feature 1                                           
AAL66409     664 rrLEDISEDPSWARVVNLNALLMMAVAVFLWGFYA 698 human
NP_998091    628 kqLPDISENPLWKNIVNVNALIMMTVAVYFWGFYA 662 zebrafish
NP_001087699 583 sdLPDIREDPKYARLVNINALIMMSCAIFLWAYFA 617 African clawed frog
AAP43921     639 rrLEDISEDPRWARVVNLNALLMMAVATFLWGFYA 673 cattle

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