5NJ8,5V0L


Conserved Protein Domain Family
bHLH-PAS_AhR
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cd11436: bHLH-PAS_AhR 
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basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor (AhR) and similar proteins
AhR, also termed Ah receptor, or Dioxin receptor (DR), or Class E basic helix-loop-helix protein 76 (bHLHe76), is the only member of bHLH-PAS transcription regulators that bind and be activated by small chemical ligands. It is activated by Dioxin to control the expression of certain genes to influence biological processes such as apoptosis, proliferation, cell growth and differentiation. To form active DNA binding complexes AhR dimerize with a bHLH-PAS factor ARNT (Aryl hydrocarbon Nuclear Receptor Translocator).
Links
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Statistics
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PSSM-Id: 381442
Aligned: 8 rows
Threshold Bit Score: 126.962
Created: 2-Aug-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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DNA bindingdimer interface
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Structure:5NJ8; Homo sapiens AhR-ARNT complex binds DNA, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              ####### # #                    ###                     
5NJ8_A         9 AEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALK 69   human
P35869        28 AEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALK 88   human
5V0L_B         1 GSGIKSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALK 61   house mouse
AAF15280      25 AEGVKSNPSKRHRDRLNAELDRLASLLPFPQDVIAKLDKLSVLRLSVSYLRAKSFFDVALK 85   chicken
AAY42958      20 AEGVKSNPSKRHRDRLNSELDRLSSLLPFPEEVTSSLDKLSILRLSVSYLRAKNFFSVTLK 80   zebrafish
XP_007897891  27 TEGAKSNPSKRHRDRLNAELERLASLLPFPQDVVAKLDKLSVLRLSVSYLRAKSFFNVSIK 87   elephant shark
XP_014343852  20 PDGVKSNPSKRHRDRLNLELERLASLLPFPDEVTSNLDKLSILRLSVSYLRAKNFFSVALK 80   coelacanth
JC7993        25 AESVKSNPSKRHRDRLNTELERLASLLPFQEEIISKLDKLSVLRLSVSYLRAKGFFEAALQ 85   African clawed frog

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