Conserved Protein Domain Family
Sema_plexin_B3

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cd11277: Sema_plexin_B3 
The Sema domain, a protein interacting module, of Plexin B3
Plexin B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The stimulation of plexin B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Statistics
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PSSM-Id: 200538
Aligned: 6 rows
Threshold Bit Score: 760.116
Created: 7-Apr-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative Semaphorin binding site [polypeptide binding site]
Evidence:
  • Comment:Plexins function as receptors of semaphorins.
  • Comment:based on the binding of human Plexin B1 to its ligand Semaphorin 4D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                             ###                         
XP_003216907   65 FLAPNATFNHLAQAQnTGALYVGAINALYQLSPELRLVGLARTGPDQDSPECLPFrdarECPQARLTDNSNKLLLTNEr- 143  green anole
Q9ULL4         47 FSAPNTTLNHLALAPgRGTLYVGAVNRLFQLSPELQLEAVAVTGPVIDSPDCVPFrdpaECPQAQLTDNANQLLLVSSr- 125  human
XP_002935540   24 FLRPNVTFNHMARDPtSGFIYIGAVNWIFQLSSDLQLLLEDSTGPREDSPECLPFkdlkDCRQATLTPNTNKLLAVNTh- 102  western clawe...
XP_694914      34 ISLNGSRLNHLLLDShSGHVYIGAVNVLYHLSPDLQLLSWGKTGPKLDSPDCLPPidpnDCTQAATTDNTNKLLLLEEvr 113  zebrafish
XP_001378100   91 FSAPNTTFNHLAMDAaTGMLYVGAVNHLYQLTPDLQQVGEAVTGPIWDSPDCLPFrdrtECPQARPTDNANQLLLVSGq- 169  gray short-ta...
XP_549363      29 FSAPNATFNHLALAPgLGTLYVGAVNRLFQLSPELRLQAVAVTGPVLDSPDCVPFrdpaDCPHARLTDNANQLLLVSGr- 107  dog
Feature 1                                                                                         
XP_003216907  144 ---aGELVVCGQLFQGVCEKRALADIAKVLYRPEDPgdnQFVAANEPRVSTVGLLGrhg-grDLLFVGRGLTaklsGGIP 219  green anole
Q9ULL4        126 ---aQELVACGQVRQGVCETRRLGDVAEVLYQAEDPgdgQFVAANTPGVATVGLVVplp-grDLLLVARGLAgklsAGVP 201  human
XP_002935540  103 ---gGELITCGQVFQGICEKRRLSNISDIIFQTIDPgdnQFVAANDPKVTTVGIVEgpsenhQLLFVGRGLTarlsSGIP 179  western clawe...
XP_694914     114 ggnsSSLIVCGTVLQGICEKRSLHNVSQVLYKTDNPvdtQYVAANDPRVSTVGVVVeqk-gvPLMLVGRGYTskgpGGIP 192  zebrafish
XP_001378100  170 ---aRELVACGQVRQGVCEKRSLGNVAQLVFRAEDPgdgQFVAANAPGVATVGLVVsap-grDLLYVARGLAgklsAGVP 245  gray short-ta...
XP_549363     108 ---aRELVACGQVRQGVCDKRRLDDVAHVLYQAEDPgdgQFVAANAPGVATVGLVVqap-drDLLLVARGLAgklsAGVP 183  dog
Feature 1                              #    #    ##                     #                         
XP_003216907  220 PFTIRQLeg-----aqAFSNEGMGKLVVGDFSDYNNSYVGAFASDGYVYFLFSRRGAKAQmEYRTYLSRSCmEDTNLYSY 294  green anole
Q9ULL4        202 PLAIRQLag-----sqPFSSEGLGRLVVGDFSDYNNSYVGAFADARSAYFVFRRRGARAQaEYRSYVARVClGDTNLYSY 276  human
XP_002935540  180 PITIRQLek-----tpVFSNEGLGKLVVGDFSDYNNTFVGIFSNNGHVYFLFFRRGSKSQmDYNTYLGSVCtGDVHLYSY 254  western clawe...
XP_694914     193 PITMRRLtpverhsapAFSHEELGKLVVGSYSEYNNHFVNAFHHNSYVYFVFSRRDVWGRrEYRTYVSRLCaGDPFFYSY 272  zebrafish
XP_001378100  246 PLTVRQLag-----pqAFSSEGLGRLVVGDFSDYNNSYVGAFAGTQFAYFLFRRRGSRTQaDYRSYVARVClNDANLYSY 320  gray short-ta...
XP_549363     184 PLTVRQLag-----pqPFSSEGLGRLVVGDLSDYNNSYVGAFAAGRSAYFVFRRRGARAQaDYRSYAARVClGDANLYSY 258  dog
Feature 1                                                                                         
XP_003216907  295 VELPLECQdakgrIYNLAQAVHLAPgyagqgKTLFVVLAAGQGSTaapttQTALCLYSLRDVDEAMERTRQLCYTsagig 374  green anole
Q9ULL4        277 VEVPLACQ-----GQGLIQAAFLAP------GTLLGVFAAGPRGT-----QAALCAFPMVELGASMEQARRLCYTaggrg 340  human
XP_002935540  255 VEVPLVCQg----GYNLAQAAYLETg----nRELFVVFAASQGPTpnpssRTALCSYKMVDIESRIENAREMCYTna-gm 325  western clawe...
XP_694914     273 VEVPLSCNg----GYNLAQAAVLGFhr--eqPALFVAMAMGQASTptptdKSALCVYTVEELDKALHAAQLLCYTqegkd 346  zebrafish
XP_001378100  321 VEMPLVCQ-----GYSLVQAAYLAPg----qGGGTLLVVASPGPMg----GSALCAFPLQEVDSRMERARRLCYTmg-gh 386  gray short-ta...
XP_549363     259 VEVPLACR-----GQGLIQAAAVTP------STLLGAFAAGPNGA-----GAALCAFPLARLDASMEHARRLCYTaggrs 322  dog
Feature 1                            ##                                                           
XP_003216907  375 PTKEEEAAIEYGVTSRCNSLPkes-------------------------------------------------------- 398  green anole
Q9ULL4        341 PSGAEEATVEYGVTSRCVTLPlds-------------------------------------------------------- 364  human
XP_002935540  326 GNDKEEAVIEYGVNSKCGKLSkdt-------------------------------------------------------- 349  western clawe...
XP_694914     347 VNNKEKAYIEYEVSSRCLNLPqds-------------------------------------------------------- 370  zebrafish
XP_001378100  387 SPAGEEATIEYGVTSRCVFLPsds-------------------------------------------------------- 410  gray short-ta...
XP_549363     323 PGGAEEATVEYGVTSRCAALPavsapparslrtvsgscrrspglrvagrcrvtaacdrlgggcqggagsrlpwasffwcf 402  dog
Feature 1                  #    ###                                                               
XP_003216907  399 ------peAYPCGDEHTPSPIASRKPLVAEALLTTvPSLTAVAAMVEagHTIAFLGDGVGQLHKVYLNgsa-aqVYSTIP 471  green anole
Q9ULL4        365 ------peSYPCGDEHTPSPIAGRQPLEVQPLLKLgQPVSAVAALQAdgHMIAFLGDTQGQLYKVFLHgsq-gqVYHSQQ 437  human
XP_002935540  350 ------pqLFQCGGEHTPSPIASRVPVEATPLLKDlSSLTAVAALAEdtYTIAFLGDAAGNIHKVTKMpvaecsTFSSCD 423  western clawe...
XP_694914     371 ------ltEYPCGGEHTPSPIASAIPLHATPAFTWtPPITAVTTATEvgHTIVLLGDKSGRLHKVFLHangtgtKYDTVE 444  zebrafish
XP_001378100  411 ------pdSYPCGDEHTPSPIASHQPLEAEPLLTSiPHLSAVAALEEagHTIVFLGDTQGQLHKVFLNgst-gqLYSSLP 483  gray short-ta...
XP_549363     403 flrrdspeSYPCGDEHTPSPIAGRQPLEAEPLLQLeQPVSAVAGLQAdgHTIAFLGDTQGQLHKVFLNgsh-ghVYHSQQ 481  dog
Feature 1                                                        
XP_003216907  472 TGq-------RSPVN------PDLLLDTSGAYLYVMTTFQVSKVPVS 505  green anole
Q9ULL4        438 VGp------pGSAIS------PDLLLDSSGSHLYVLTAHQVDRIPVA 472  human
XP_002935540  424 SClaardpfcGWCVLqgrcmaKQQCVDYTEENHYLWSYDKEATCLAI 470  western clawed frog
XP_694914     445 VDp-------ESPIN------ADLLLDATKQNVFVLTERKVTKLHVA 478  zebrafish
XP_001378100  484 VGp------pGTAVN------PDLLLDRNGSHLYVMTSSQVTKVPIS 518  gray short-tailed opossum
XP_549363     482 VGp------rGSAIS------PDLLVDGNGSHVYVLTAQQVDRVPVA 516  dog

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