Conserved Protein Domain Family
Sema_plexin_B2
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cd11276: Sema_plexin_B2 
The Sema domain, a protein interacting module, of Plexin B2
Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Links
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Statistics
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PSSM-Id: 200537
Aligned: 6 rows
Threshold Bit Score: 764.32
Created: 7-Apr-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative
Feature 1:putative Semaphorin binding site [polypeptide binding site]
Evidence:
  • Comment:Plexins function as receptors of semaphorins.
  • Comment:based on the binding of human Plexin B1 to its ligand Semaphorin 4D
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                ###                      
ACJ64908       26 QFSSPTIINNVVQDPqTGRIYLGAVNGIFQLNHNLQ---EESRADTGPKKDNPQCTPPIt-aQCTDAKEMDNFNKLLLVN 101  zebrafish
O15031         27 FFRSEKELNHLAVDEaSGVVYLGAVNALYQLDAKLQ---LEQQVATGPALDNKKCTPPIeasQCHEAEMTDNVNQLLLLD 103  human
NP_001184245   25 EFSTDTPINNVVQDPlTGRVYLGAVNAIYQLDSLLN---LEARAETGPKKDAKGCTPPVs--TCQDLKDTNNTNKLLLVH 99   zebrafish
XP_003221365   27 SFQSKTELSHLTVNHeTGTVYLGALNTLYQLTKDLKpypSVEEVSTGPHLDNKKCTPPIdenQCTEAKMTDNYNKILLLD 106  green anole
XP_423623      40 FFQSATELNHLTVDNdTGIIYLGVVNALYQLTENLV---VRIHVETGPRKDNKKCTPPIeenQCKEAVLTDNYNKLLLLN 116  chicken
CAF93750       28 EFVSATLINNVVADPqTGLLYVGAVNSLHQLSPDLQ---VLSRSETGPKRDNRLCTPPVt-eACEEAVDTDNHNKLLLVH 103  spotted green...

Feature 1                                                                                         
ACJ64908      102 SanGTLIVCGSLFRGICSLVNLNSVNKPVYYSDtkgEKTYVASTEESVTVVGVISyfkdtttnanlSVFLVGKGYGssDS 181  zebrafish
O15031        104 PprKRLVECGSLFKGICALRALSNISLRLFYEDgsgEKSFVASNDEGVATVGLVSstgp----ggdRVLFVGKGNGphDN 179  human
NP_001184245  100 SanGSLIVCGSLYRGICSLLNLTNVKEQIYYSDskgERTYAASTEDYVSVVGVMAtleid--nkpfSVFLVGKGYGsmDS 177  zebrafish
XP_003221365  107 MqeRKIVVCGSLFKGICSIRELENIANTTYYENgsgEKSFVASNDENVITVGLITslk------rgRMMFVGKGNGlnDN 180  green anole
XP_423623     117 KenKTIVVCGSLFKGICATRDLENITKVMHYVEtsgEKSFVASNDENVSTVGLITsld------ndQVLFVGKGNGpnDN 190  chicken
CAF93750      104 RaqNALVVCGSVFRGICSLRNLSRVEEVIYYSDtkgEKSYVASTEEGVSVVGVMSyyqkg--gedlAVFLVGKGYGsqDS 181  spotted green...

Feature 1                              #    #      ##                     #                       
ACJ64908      182 SKLISTRLLqehgemDVFENMVEASTVQTsAFVLRYHHDFRYTFKDNGYIYFLFSRSPGTSDsTKITFIARLCeNDHHYY 261  zebrafish
O15031        180 GIIVSTRLLdrtdsrEAFEAYTDHATYKA-GYLSTNTQQFVAAFEDGPYVFFVFNQQDKHPA-RNRTLLARMCrEDPNYY 257  human
NP_001184245  178 SKLISTRIVqnyrdwVVFESIIEASTVQAvPFVPKYLHDFRFAFKSDNFVYFLFSRTLGRTDnKNFTFISRLCeNDNHYY 257  zebrafish
XP_003221365  181 GVIISTRQLfngdnrEIFELYADHAAIKS-AYPSASSQQFLYVFENNKFVYFIFNQNNNPGT-INRTLIGRLCkDDESYH 258  green anole
XP_423623     191 GIIISTRQLhekdgkDIFEMYSDSAAVKS-AYHSSSTQQFVTVFEDKNYVYFIFNQQEKQPV-NNRTLIARLCkDDAHYY 268  chicken
CAF93750      182 TKLISTRILqdygdwVVFDNIIEAAAVQSnPFVLRYLHNFRFAFKDRSYVYFLFSRTLGAQDtKNFTFIARLCeNDHGYY 261  spotted green...

Feature 1                                                                                         
ACJ64908      262 SYTELQLNCTvnteqqenTFNKVQAAYLAKPgkvlaqn------ivpsnlnDKVLFGVFSADEADG---RSALCMYPLSS 332  zebrafish
O15031        258 SYLEMDLQCRdpdi-haaAFGTCLAASVAAPg------------------sGRVLYAVFSRDSRSSggpGAGLCLFPLDK 318  human
NP_001184245  258 SYTELQLSCGln-----nRYNKVQAAYLSDPgkelaqvmtdsgeygtikewDKVLFVVASSEEGAT---ESALCMYPLKN 329  zebrafish
XP_003221365  259 SYFEMDLECQdg----sgPYNQSNAIYASIPvqipgq--------dneilsDTILIGLFRRMGKGSl--ECAMCRFSLKA 324  green anole
XP_423623     269 SYFEMDLGCKde----dgSYDHCHSAYVTTPgeelaksmaqqrqttdsasdDKELIALFSKVNKDNgslKSAMCVFSLRH 344  chicken
CAF93750      262 SYTELQLNCStg-----nKHNKAQAAFVTTPgpvlvqnisswdqdgvvsasDKVLFVTFTSDDEPS---SSAMCMFPLRS 333  spotted green...

Feature 1                                                  ##       #    ###                      
ACJ64908      333 INARFEEVIESCYTgevleDDKPKTVYSPYns-knEAICKTKRdknmvkAYICGAEFLPSPLASKpEYALAvkPIYTRn- 410  zebrafish
O15031        319 VHAKMEANRNACYTg---tREARDIFYKPFh---gDIQCGGHApgs-skSFPCGSEHLPYPLGSRdGLRGT--AVLQRgg 389  human
NP_001184245  330 INQKLLAIVTACYTdn-gkIDDRLVVESPYts-skDGPCVKHDkdi-vnRYKCGADFLPSPLASRqEFALKanPVFIRq- 405  zebrafish
XP_003221365  325 INEKMEQNREKCYM-----KDDRDVFYKPFrteqaPCITASHQns--sqTFPCGSEHLPYPLGSK-EGISAe-PLLKKdg 395  green anole
XP_423623     345 INEKMEKNRDDCYT-----NKNTSMFYKLFa---vENPCGQHGqna-skNFPCGSEHLPYLLGSKnGVIEK--PVLQKeg 413  chicken
CAF93750      334 INRRLMEMLEACYSgn-gvINGKPGVYLPYss--kPDDCQSHQqknmleSNKCGAEFLPSPLASRaEAALTaePLLVRk- 409  spotted green...

Feature 1                                                                                        
ACJ64908      411 DMLTAVAVAVEneHTVAFLGTSGADVLKVHLdpn-htdFYNRIPGDradGAVNKNLLFDSTLNHLYITTGKKISKVSVQ 488  zebrafish
O15031        390 LNLTAVTVAAEnnHTVAFLGTSDGRILKVYLtpdgtssEYDSILVEi-nKRVKRDLVLSGDLGSLYAMTQDKVFRLPVQ 467  human
NP_001184245  406 NLLTAVAVAVEndHTIAFLGHNAGEVIKVHLsss--pePYNPGPGYktsGYVNKNLFFDKTQAHLYITTEKKIVKVPVQ 482  zebrafish
XP_003221365  396 INLTAVTFTVEngKTVVFVGTSDGRILKVALsnp--akEYASILIEk-nKPIQRDLVLDATHENLYVMTTNKVFRLPVQ 471  green anole
XP_423623     414 MNLTAVTVTVEngHTVAFLGTSDGKILKVFLsst--viEYSSLTIEl-nKPIKNDLVLDKTQEYLYVMTTDKVHRLPVQ 489  chicken
CAF93750      410 AELTAVAVSVEmeHTVAFVGTASGEVLKVHLsar--peVYGRASAEltrDKVNKNLLLDPSGRHLYITRERRITKVPVQ 486  spotted green ...

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