3OL2


Conserved Protein Domain Family
Sema_plexin_B1
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cd11275: Sema_plexin_B1 
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The Sema domain, a protein interacting module, of Plexin B1
Plexin B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D-plexin B signaling complex regulates dendritic and axonal complexity. The activation of Plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
Links
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Statistics
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PSSM-Id: 200536
Aligned: 4 rows
Threshold Bit Score: 845.782
Created: 7-Apr-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Semaphorin
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1:Semaphorin binding site [polypeptide binding site]
Evidence:
  • Comment:The ligand of Plexin B1 is semaphorin 4D.
  • Structure:3OL2; Human Plexin B1 binds to its ligand Semaphorin 4D, contacts at 4A distance.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                             ###                         
3OL2_B         12 FTPNGTYLQHLARDPtSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVmpdECPQAQPTNNPNQLLLVSPg- 90   human
XP_002194843   27 FSHNSTKFLHLSMDLeSGTIYLGATNFLFQLTSDLLLENMVQTGPVLDSKDCLPPVsklECPQAHHTDNHNKLLLVNPvq 106  zebra finch
XP_414386     105 FSRNATKFLHLSMDVeSGTIYLGATNFLFQLTPDLLMENMVQTGPVLDSKDCLPPVsklECPQAHHTDNHNKLLLVNSvq 184  chicken
XP_002938438   35 FVQNNTIFNHLTLDAnTGTLYVGATNSLYQLTENLAVEMLVRTGPVWDSKECLPPVs-tDCPQAQNTNNHNKLLLVVPsk 113  western clawe...

Feature 1                                       # ###                                     #       
3OL2_B         91 -ALVVCGSVHQGVCEQRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVAqglagePLLFVGRGYTSRgvGGGIPPIT 169  human
XP_002194843  107 kELIVCGSVHQGICEKRSLASIDHVLFRPESPGDTQYVAANDPNITTVGLIAyskdevPLLFVGRGYTSRgvGGGIPPIT 186  zebra finch
XP_414386     185 kELIVCGSVHQGICEKRSLTSIDHVLFRPESPGDTQYVAANDPNITTVGLVAyskdevPLLFVGRGYTSRgvGGGIPPIT 264  chicken
XP_002938438  114 rELIVCGSVYQGICESRRLGSVQTVLFRPERPVDTQYVAANDPNVTTVGLVAlskdgsPLLFVGRGYTSKg-AGGIPPIT 192  western clawe...

Feature 1                                #    # # # ##                     #      #               
3OL2_B        170 TRALwppd-------pqaAFSYEETAKLAVG-RLSEYSHHFVSAFARGASAYFLFLRRDLQAQSRAFRAYVSRVCLRDQH 241  human
XP_002194843  187 TRNLrahggdvqatdshsIFSYEETAKLAVG-RLSEYNHHFIKSFTYHSSVYFLFYRRDLKSQSREYKTYISRICLDDSH 265  zebra finch
XP_414386     265 TRNLrahgsdvqatdshsIFSYEETAKLAVG-RLSEYNHHFIKSFTYRSSVYFLFYRRDLKSQSREYKTYISRICLDDSH 343  chicken
XP_002938438  193 TRNLevggds--emeshsVFSYEDTAKLAVVgRLSEYNHHFIKAFTHKSNVYFLFYRRDLKSQSREYKTYISRICPNDSH 270  western clawe...

Feature 1                                                                                         
3OL2_B        242 YYSYVELPLACEg--gRYGLIQAAAVATsre-------vahGEVLFAAFSSAAPPTvgrppsaaagasgASALCAFPLDE 312  human
XP_002194843  266 YYSYVELPLLCQskanTYSLLQAAYVTRpgkelaqgqldteGEVLFAAFSAWQASSgkl--------seESALCVYTMEE 337  zebra finch
XP_414386     344 YYSYVELPLLCQskanTYSLLQAAYVTQpgkdlaqgqldtdGEVLFAAFSAWQASSgkl--------seESALCIYAMEE 415  chicken
XP_002938438  271 YYSYVELPLSCRtkdkSYNLLQAAYVTQpgerlakgvlktdGDVLFAAFSQWQAASgkv--------geESGLCLYSMDL 342  western clawe...

Feature 1                                         ##    ##      #    ###                          
3OL2_B        313 VDRLANRTRDACYTREgrAEDGTEVAYIEYDVNSDCAQLPVDTldAYPCGSDHTPSPMASRVPLEAtPILEWpgIQLTAV 392  human
XP_002194843  338 VDRLTNWTRDVCYMRDgkSEEGTEVAYIEYDVSSNCVQLPADTlyAYPCGSDHTPSPMASRVPLEAaPLLEKteARLTAV 417  zebra finch
XP_414386     416 VDRLTNWTRDVCYMRDgkSEDGTEVAYIEYDVSSNCVQLPADTlyAYPCGSDHTPSPMASRVPLEAaPLLETteSRLTAV 495  chicken
XP_002938438  343 IDRLINQTRDTCYTKDgkAEDGREVAYIEYDVKSNCVQLPSDTldAYPWGWDHTPSPMASKDPREAtPLFESvtTGFTAI 422  western clawe...

Feature 1                                                                                         
3OL2_B        393 AVTMEdgHTIAFLGDSQGQLHRVYLgpgs----------dghPYSTQSIQq---------------------gSAVSRDL 441  human
XP_002194843  418 AVNVEdgHTIAFLGDSRGRLHKVYLgaqg----------eahTYASVSIQv---------------------nSMVSGDL 466  zebra finch
XP_414386     496 AVNVEdgHTIAFLGDSRGRLHKVFLgamg----------dahIYASLAIQl---------------------nSMVSGDL 544  chicken
XP_002938438  423 AGHGEgeHTIAFIGDSKGYLNKXXXxxxxxxxxxxxxxxgpsTFSYIQTLftkvylggeqdtrqyssvgtqsnSAVLPDL 502  western clawe...

Feature 1                                
3OL2_B        442 TFDGTFEHLYVMTQSTLLKVPVA 464  human
XP_002194843  467 LFDQLQEHLFVMTQSMVVKVPIM 489  zebra finch
XP_414386     545 LFDQLQEHLFVMTQSMVLKVPIL 567  chicken
XP_002938438  503 LFDQEEKHLYILTQSTVMKVPLS 525  western clawed frog

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