Conserved Protein Domain Family
Sema_6E
?
cd11270: Sema_6E 
The Sema domain, a protein interacting module, semaphorin 6E (sema6E)
Sema6E is expressed predominantly in the nervous system during embryogenesis. It binds Plexin A1 and might utilize it as a receptor to repel axons of specific types during development. Sema6E acts as a repellent to dorsal root ganglion axons as well as sympathetic axons. Sema6E is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.
Links
?
Statistics
?
PSSM-Id: 200531
Aligned: 3 rows
Threshold Bit Score: 760.8
Created: 6-Jun-2011
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
plexin bindinghomodimer
Feature 1:plexin binding site [polypeptide binding site]
Evidence:
  • Comment:based on the binding of mouse Semaphorin 6A to Plexin A2
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                  ####                   
BAJ34941       60 DNDTARLGLDFQRMLRINHMVYIAARDHVFAINLSASLERIVPQQKLTWKTkDVEKCTVRGKNSDECYNYIKVLVPRNDE 139  zebrafish
XP_002937315   50 DDDTAHLGLDFQKMLKLNQTLFVAARDHVYAIDLRRAKEAIIPDKYVTWKTqDMENCAMRGKLRDECYNYIKVLVPKNDQ 129  western clawe...
NP_001186294   60 DNDTARLGLDFQRMLRINHMVYIAARDHVFAINLSASLERIVPQQKLTWKTkDVEKCTVRGKNSDECYNYIKVLVPRNDE 139  zebrafish

Feature 1                                        ##                        # ##      #            
BAJ34941      140 TLFACGTNAFNPTCRNYKmssleqdGEEVIGQARCPFESRQSNVGLFAGGDFYSATMTDFLASDAVIYRSLGEsspvLRT 219  zebrafish
XP_002937315  130 TLVACGTNSFNPMCRSYKiktleqeGEEFNGQARCPFDAKQANVALFADGNLYSATMADFQASDAVIYRSLGEkspvLRT 209  western clawe...
NP_001186294  140 TLFACGTNAFNPTCRNYKmssleqdGEEVIGQARCPFESRQSNVGLFAGGDFYSATMTDFLASDAVIYRSLGEsspvLRT 219  zebrafish

Feature 1           ###    #                                              ##  #                   
BAJ34941      220 VKYDSKWLREPHFLHAIEYGNYVYFFLSEIAVEYTTLGKVVFSRVARVCKNDNGGSPRVLERYWTSFLKARLNCSVPGDS 299  zebrafish
XP_002937315  210 VKYDSKWLREPHFIHAVEYGNYVYFFFREISMEYTTIGKVTFSRVGRVCKNDMGGSPRVLEKYWTSFLKARLNCSVPGDS 289  western clawe...
NP_001186294  220 VKYDSKWLREPHFLHAIEYGNYVYFFLSEIAVEYTTLGKVVFSRVARVCKNDNGGSPRVLERYWTSFLKARLNCSVPGDS 299  zebrafish

Feature 1                                                                                         
BAJ34941      300 FFYFDVLQSLTNVMQINHRPAVLGVFTTQANSITGSAVCAFYMDDIEKVFNGKFKEqrnsesAWTPVPDEAVPKPRPGSC 379  zebrafish
XP_002937315  290 FFYFDVLQSVSDILTINNRPAVIGVFGTQANSITGSGVCAYYMDDIEKVFNGKFKEqkttesAWTPIPEDKVPTPRPGCC 369  western clawe...
NP_001186294  300 FFYFDVLQSLTNVMQINHRPAVLGVFTTQANSITGSAVCAFYMDDIEKVFNGKFKEqrnsesAWTPVPDEAVPKPRPGSC 379  zebrafish

Feature 1                                #                                                        
BAJ34941      380 agdgpaagyksSTNFPDETLTFIKSYPLMDEAVPSVnNRPCFTRTTSRFKLTQIAVDTAAGPYKNYTVVFLGSENGHVLK 459  zebrafish
XP_002937315  370 agygkaatyktSNEFPDETLSFIKSYPLLDEAVLSItETPWFTKTTSRFKLTHLAADTSAGPYGNYTVLFLGSEDGKVLK 449  western clawe...
NP_001186294  380 agdgpaagyksSTNFPDETLTFIKSYPLMDEAVPSVnNRPCFTRTTSRFKLTQIAVDTAAGPYKNYTVVFLGSENGHVLK 459  zebrafish

Feature 1                                                                       
BAJ34941      460 VLASMHPNSsySTQVLEDIDVYNPNKCNvrgedRRILGLELDKDHHALFVAFTgCVIRVPLS 521  zebrafish
XP_002937315  450 VLSGTTENStvETLLLEDINVYNPAKCNvkkedRRILGLQLDRENHALFVAFSsCIIRVPLS 511  western clawed frog
NP_001186294  460 VLASMHPNSsySTQVLEDIDVYNPNKCNvrgedRRILGLELDKDHHALFVAFTgCVIRVPLS 521  zebrafish

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap