Conserved Protein Domain Family
Sema_6B
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cd11267: Sema_6B 
The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B)
Sema6B functions as repellents for axon growth; this repulsive activity is mediated by its receptor Plexin A4. Sema6B is expressed in CA3, and repels mossy fibers in a Plexin A4 dependent manner. In human, it was shown that peroxisome proliferator-activated receptors (PPARs) and 9-cis-retinoic acid receptor (RXR) regulate human semaphorin 6B (Sema6B) gene expression. Sema6B is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.
Links
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Statistics
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PSSM-Id: 200528
Aligned: 5 rows
Threshold Bit Score: 963.524
Created: 7-Apr-2011
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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plexin bindinghomodimer
Feature 1:plexin binding site [polypeptide binding site]
Evidence:
  • Comment:based on the binding of mouse Semaphorin 6A to Plexin A2
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
EAW69207      57 TPAEGADDLNIQRVLRVNRTLFIGDRDNLYRVELEPpTSTELRYQ-----------------------RKLTWRSNPSDI 113  human
XP_002660976 161 RSYTRQEPLYIQTVLRVNRTLYIGARDDLYRVELDHvSGDEMFYS-----------------------KKRTWESNKNDI 217  zebrafish
XP_002942249  52 TAERERDRLNIQKILMVNRTLYVGDRDALYQIMLDS-YSTELQYH-----------------------KKLIWKSNHQDI 107  western clawed...
CAG07759      11 HRSSLRQELHIQTVLQVNRTLYIGSRDDLYRVELDNmAGDEMFYSkvradakkqrvnsnrtlnaalsfQKRTWESNKNDI 90   spotted green ...
XP_425890    105 PEGGGTERLNIQRILKVNRTLFVGDRDNVYRVSLEPtAGSEMRYH-----------------------RKLTWRSNQHDI 161  chicken

Feature 1           ####                                                  ##                     
EAW69207     114 NVCRMKGKQEGECRNFVKVLLLRdESTLFVCGSNAFNPVCANYSIDTLqpvGDNISGMARCPYDPKHANVALFSDGMLFT 193  human
XP_002660976 218 RICRMKGKHEEECRNYIKVLLSH-DGGLFVCGTNAFNPLCANYTVNTLelvGEPISGMARCPYDPKHANVALFAEGSLFT 296  zebrafish
XP_002942249 108 NVCRMKGKQEDECRNFVKVLLLKdYQTLFICGTNAFNPVCADYSIDTLeqvGDTLSGMARCPYDPKHANVALFADGMLFT 187  western clawed...
CAG07759      91 RVCRMKGKHEGECRNYIKVLLSQ-HGGLFVCGTNAFNPLCANYTVNTLemvGEPVSGMARCPYDPRHANVALFSDGSLFT 169  spotted green ...
XP_425890    162 SICRMKGKHEAECRNFIKVMLVRnQNLLFVCGTNAFNPICANYSMDTLepiGDNISGMARCPYDPKHANVALFTGGMLFT 241  chicken

Feature 1           # ##      #             ###    #                                             
EAW69207     194 ATVTDFLAIDAVIYRSLGDrptLRTVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGG 273  human
XP_002660976 297 GTVTDFLAIDAVIYRSLGEspaLRTIKHDSKWFREPYFVSAVEWGPHIYFFFREMAMEFNYLEKVMVSRVARVCKGDLGG 376  zebrafish
XP_002942249 188 ATVTDFLAIDAVLYRSLGPrlaLRSVKHDSKWFKDPYFVHAVEWKEHVYFFFREVAMEFNYLEKVVVSRVARVCKNDMGG 267  western clawed...
CAG07759     170 ATVTDFLAIDAVIYRSLGDspaLRTVKHDSKWFREPYFVSSMEWGPHIYFFFREMAMEFHHLEKVMVSRVARVCKADLGG 249  spotted green ...
XP_425890    242 ATVTDFLAIDAVIYRSLGDsptLRTVKHDSKWFKEPYFVHAVEWRSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDMGG 321  chicken

Feature 1         ##  #                                                                          
EAW69207     274 SPRVLEKQWTSFLKARLNCSVPGDSHFYFNVLQAVTGVVSLGGRPVVLAVFSTPS------------------------- 328  human
XP_002660976 377 SQRVLERQWTSFLKARLNCSIPGDSHFYFNLLQSTSPIIRMQGRDVILGVFSTPS------------------------- 431  zebrafish
XP_002942249 268 SQRVLEKQFSSFLKARLNCSVPGDSHFYFNVIQTVSNILNIGGRQVVLALFSTPT------------------------- 322  western clawed...
CAG07759     250 SQRVLEKQWTTFLKARLNCSVPGDSHFYFNLLHATSDIIHMQGRDVILGLFSTPPnrhaatqrpgwkergpvcpygcllv 329  spotted green ...
XP_425890    322 SQRVLEKQWTSFLKARLNCSVPGDSHFYFNVIHAVTDILELNGRPVVLAVFSTPT------------------------- 376  chicken

Feature 1                                                                                #       
EAW69207     329 -NSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAapgmqynaSSALPDDILNFVKTHPLMDE 407  human
XP_002660976 432 -NSIPGSAVCAFDMQQLARVFEGRFKEQKSPESIWTPVPDELVPRPRPGGCAvqgsrfstSNTLPDEVLNFIKIHPLMDE 510  zebrafish
XP_002942249 323 -NSIPGSAVCVFDMEQVASVFSGRFREQRSPDSVWTPVPEELVPRPRPGCCVghshpynsSRSLPDEVLNFVKSHPLMED 401  western clawed...
CAG07759     330 sSSIPGSAVCVFDMQQLARVFEGRFKEQKSPESIWTPVPDEAVPKPRPGGCAvqgsrfssSTTLPDEVLNFVKTHPLMDE 409  spotted green ...
XP_425890    377 -NSIPGSAVCAFDMTQVAAVFEGRFREQKSPESIWTAVPEDMVPKPRPGCCAapgmrynsSSTFPDEILTFVKTHPLMDE 455  chicken

Feature 1                                                                                        
EAW69207     408 AVPSLgHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAGTVLKFLVRPNASTsgt----sgLSVFLEEFETYRP 483  human
XP_002660976 511 AVPLLgHRPWIVKTMVRYQLNTMVVDTEAGPHRNRTVVFLGSTRGTVLKFLITPSPENqy-----snTNTFLEELEGYNP 585  zebrafish
XP_002942249 402 SVPSIgGFPWITRTLTRNQLTHLAVDASSGVHGNHTVLFLASDSGTVLKYLLIPKMSGseig-tlanQTVLLEELQTYPA 480  western clawed...
CAG07759     410 TVPLLgHRPWVVKTMGRYQLTAMVVDTEAGPHKNRTVLFLGSTRGTILKFLMIPSGDSvs------hSSVFLEEVEGFNP 483  spotted green ...
XP_425890    456 AVPSLgNAPWIVRTMSRYQLRKIVVDNAAGPWGNHTVVFLGSSTGTILKFLIHPNATSspapappgsQSVFLEEFETYQP 535  chicken

Feature 1                                                  
EAW69207     484 DRCGrpgggetgQRLLSLELDAASGGLLAAFPr-CVVRVPVA 524  human
XP_002660976 586 ERCGdds--aqaMQPLSLTLDKPSHTLLLAFHs-CVVRVPVA 624  zebrafish
XP_002942249 481 NRCGwde---edQKILGIEVDKGSGSLLLAYSs-CIVKVPLA 518  western clawed frog
CAG07759     484 EKCGeds--pqaRQLLSLTLDRTSHTLLLAFPa-CLIRMPTS 522  spotted green pufferfish
XP_425890    536 GRSQn-------QKGLYFSLFCETCGLVGIFVvaSVTADPSG 570  chicken

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