Conserved Protein Domain Family
Sema_4E
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cd11260: Sema_4E 
The Sema domain, a protein interacting module, of semaphorin 4E (Sema4E)
Sema4E is expressed in the epithelial cells that line the pharyngeal arches in zebrafish. It may act as a guidance molecule to restrict the branchiomotor axons to the mesenchymal cells. Gain-of-function and loss-of-function studies demonstrate that Sema4E is essential for the guidance of facial axons from the hindbrain into their pharyngeal arch targets and is sufficient for guidance of gill motor axons. Sema4E guides facial motor axons by a repulsive action. Sema4E belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.
Links
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Statistics
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PSSM-Id: 200521
Aligned: 3 rows
Threshold Bit Score: 916.989
Created: 11-Apr-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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plexin bindingputative
Feature 1:plexin binding site [polypeptide binding site]
Evidence:
  • Comment:based on the binding of semaphorin 4A to its receptor Plexin B1
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                 ###                    
Q9YHX4        45 FREEGIWNYTTMLLRDDLNLLILGAREAIFALDLDditikKAMLKWEVtrDQQNDCSNKGkdaTNDCKNYIRILHKKNDG 124 zebrafish
NP_001038473  26 FKEQGIWNYSTMLIREDLGLLVLGAREAVFALDINdisvsRSKVLWKVteEKQKECTSKGkhpDIDCHNYIRMLHQMNDS 105 zebrafish
XP_003438028  43 FSENDVYNYSTMLLIEDKGMLMLGAREKVYALDLYnisqkRASVAWEAtpGKKTDCKNKGknaETECLNYIRILHKVGDD 122 Nile tilapia

Feature 1                                              #                    # ## #            #  
Q9YHX4       125 RMYVCGTKAFNPTCGYLsyadgkltleilqedTKGKCPFDPFQRYTSAMVDGAYYSATSMNFRGSEPVMMRSTEesIRTE 204 zebrafish
NP_001038473 106 VMYICGTNAFSPTCDYItydngqlqlegkqedGRGKCPFDPFQRSSSVMVDQDLYSATSLNFLGSEPVILRTSPitLRTL 185 zebrafish
XP_003438028 123 RMYVCGTNAFDPECYYMsfsddaltfeknmedGKGKCPFDPFQRYASIMEGNELYSATSMNFLGSKPVLMRSSSgtIRTE 202 Nile tilapia

Feature 1        # #    #                               #                       ##### #          
Q9YHX4       205 FTSTWLSEPNFIHMAHIPEGqsNPDGDDDKIYLFFSETAVEYESYTKVDVSRVARVCKGDLGGQRTLQKKWTSFLKARLD 284 zebrafish
NP_001038473 186 LKSSWLNEPNFIYMDAVPESedSPEGDDDKIYMFFSENAIEYDFYNKLVVSRVARVCKGDMGGLRTLQRKWTSFLKARLD 265 zebrafish
XP_003438028 203 FKSSWLNEPTFVSMAQMPESkeSESGDDDKVYLFFSETAVECDCYNKLVVSRVARVCKGDLGGQRTLQKKWTTFLKARID 282 Nile tilapia

Feature 1                                                                                 ##     
Q9YHX4       285 CQVPNTNLPLLVQDVFHLc--pDDWTTCVFYAVFTPQSds-sQYSAVCSYKIEDIKTVFSKGKFKAPfnvetSFVKWVMY 361 zebrafish
NP_001038473 266 CSVPEPSLPYVIQDVFHVr--hQKWRKSVFYAIFTSQSsstdQSSAVCAYNVTDISNVFSRGKFKTEvavemSDVKWVTY 343 zebrafish
XP_003438028 283 CPVLESQLPYIIRDAYRWcdpeKDWKSCIFYTVFTAQSdt-sDLSAVCAYRVSDISRVFAEGKYKTPvpvetSFVKWVMY 361 Nile tilapia

Feature 1                                     #   #  #                                           
Q9YHX4       362 SGELPDPRPGACIDNharekgitksleLPDKTLQFVKDKPLMDQAVTA--EQPLLVKRGAAFTRIVVTtATALNGTSHQV 439 zebrafish
NP_001038473 344 SGDLPVPRPGDCINNaartsgikssmnIPDKTLQFIRDRPLMDDAVHPitGKPLLLKRGPLLTRLVVDmVTAADGQSYPM 423 zebrafish
XP_003438028 362 SGEVPVPRPGACINNearkagiqktldLPDRTLQFVKDKPLMDQIIQPigDKPLLVRRGATFTQIIVNqMKAADGNKYPV 441 Nile tilapia

Feature 1                                                                     
Q9YHX4       440 MFIGTKSGSVLKAVNYNGEMVIMEEIQLFDPSEPIKILRLSSskKQLYVGSeVGVVQLSIS 500 zebrafish
NP_001038473 424 MFVGTANGYVQKAVNYDGEMHIIEEVKLFESEEAIDVLRLHQ--NQLYAGSaSGVVQMPVS 482 zebrafish
XP_003438028 442 MFIGTDKGTVLKAVNYDGEMFIIEEVQIFHPPQPIRILKFSN--ITLYAGSdTGVAQIPLA 500 Nile tilapia

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