3OL2


Conserved Protein Domain Family
Sema_4D
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cd11259: Sema_4D 
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The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
Sema4D/CD100 is expressed in immune cells and plays critical roles in immune response; it is thus termed an "immune semaphorin". It is expressed by lymphocytes and promotes the aggregation and survival of B lymphocytes and inhibits cytokine-induced migration of immune cells in vitro. Sema4D/CD100 knock-out mice demonstrate that Sema4D is required for normal activation of B and T lymphocytes. Sema4D increases B-cell and DC function using either Plexin B1 or CD72 as receptors. The function of Sema4D in immune response implicates its role in infectious and noninfectious diseases. Sema4D belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.
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Statistics
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PSSM-Id: 200520
Aligned: 6 rows
Threshold Bit Score: 930.421
Created: 11-Apr-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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plexin bindingputative
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1:plexin binding site [polypeptide binding site]
Evidence:
  • Structure:3OL2; Human Semaphorin 4D binds with its receptor Plexin B1, contacts at 4A distance.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                            ###         
3OL2_A        10 TWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKqHEVYWKVSEDKKAKCAEKGKSKQTECLN 89  human
XP_003200859  53 SWKQNDVDLLEFWEPDVFNYTTLLLNEDRGVLYVGAREAVYELNISNISIKnNQLLWKVPDIDMSMCILKGKSKETDCRN 132 zebrafish
NP_001161470  30 TWHLKETNLMHFHVSGISNYSTLLLSEEKDVLYVGAREAIFAVSSLNVAEKlHEAYWKVSDEKNNECAWKGKSKQTECLN 109 western clawed ...
NP_006369     31 TWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKqHEVYWKVSEDKKAKCAEKGKSKQTECLN 110 human
XP_002190148  27 TWEHKEVQLIHFNESKVSNYSTLLLNEDKNVLYVGARDVIFALNAVNIAEKqNELHWKVTEDKRTKCAVKGKSEQTECRN 106 zebra finch
XP_424426     17 IFLSTEVQLVHFHEPGVSNYSTLLLSEDRDVLYVGAREVIFALNAVNIAEKqHELHWKVTEDKRTKCAVKGKSEQTECRN 96  chicken

Feature 1                                                       #                    # ## #      
3OL2_A        90 YIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFkflgKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISR 169 human
XP_003200859 133 YIRVLQVLDEEHLYVCGTHAFQPLCDYLSLQDFrlleKAEDGRGKCSYDPSQSFTTVMVDGELYSGTAYNFLGSEPIISR 212 zebrafish
NP_001161470 110 YIRVIQPLNDKTLYVCGTNAFQPTCDYLNLTDFrllgRNEDGKGRCPFDPAQSYISVMVDGELYSGTSFNFLGSEPIIFR 189 western clawed ...
NP_006369    111 YIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFkflgKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISR 190 human
XP_002190148 107 YLRVLQQLNDTFLYVCGTNAFQPTCDYLNLISFelggKNEDGKGRCPFDPAHSYTSVMVDEELYSGTPYNFLGSEPVISR 186 zebra finch
XP_424426     97 YVRVLQQLNDTFLYVCGTNAFQPTCDYLNLISFelegKNEDGKGRCPFDPAQSYTSVMVDEELYSGTSYNFLGSEPIISR 176 chicken

Feature 1                #  # #    #                               #                       ##### 
3OL2_A       170 NSsh-spLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQK 248 human
XP_003200859 213 SSpsqslLRTEYSTSWLNEPSFVFADVIREGQDSPDGDDDKIYYFFTEVSVEYEFFGKLLIPRIARVCKGDLGGQRTLQK 292 zebrafish
NP_001161470 190 HSsq-sqLRTEYAVPWLNEPSFVYADVIRAPANNPEGDDDKVYFFFTEVSVEYEFFSKLLIPRVARVCKGDQGGLRTLQK 268 western clawed ...
NP_006369    191 NSsh-spLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQK 269 human
XP_002190148 187 HLhr-ssLRTEYAIPWLNEPNFVFADVIRADPNSTDGEDDKIYFFFTEVSVEYEFVGKLLIPRIARVCKRDQGGLRILQK 265 zebra finch
XP_424426    177 NShq-spLRTEYAIPWLNEPNFVFADVVRADQNSTDGEDDKIYFFFTEVSVEYEFVGKLMIPRIARVCKRDQGGLRTLQK 255 chicken

Feature 1        #                                                                               
3OL2_A       249 KWTSFLKARLICSRPdSGLVFNVLRDVFVLRSPglKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVE 328 human
XP_003200859 293 KWTSFLKAKLVCSMPeLNFVFNVVHDVFILKAPhwRDTVIYGVFTSQWGNVGLSAVCAYNMSSVHEVFSRGKYMQKVTVE 372 zebrafish
NP_001161470 269 KWTSFLKAKLICHSSeNNLIFNVVSDVFILKHSdsSEPKIYGVFTSHLNNVGLSAVCAYNVSTVEEVFAKGKYMHSATVE 348 western clawed ...
NP_006369    270 KWTSFLKARLICSRPdSGLVFNVLRDVFVLRSPglKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVE 349 human
XP_002190148 266 KWTSFLKARLICTIPdKNLIFNVINDVFILKSPtlKEPVIYGVFTPQLNDVGISAVCAYSLSAVEEVFSKGKYMQSATVE 345 zebra finch
XP_424426    256 KWTSFLKARLICTIPdKNLIFNIINDVFILKSPtlKEPVIYGVFTPQLNNVGLSAVCAYNLSAVEEVFSKGKYMQSATVE 335 chicken

Feature 1          ##                                  #   #  #                                  
3OL2_A       329 QSHTKWVRYNGPVPKPRPGACIDSEARaanytSSLNLPDKTLQFVKDHPLMDDSVTPidnRPRLIKKDVNYTQIVVDRTQ 408 human
XP_003200859 373 QSHTKWVRFNGAPPSPRPGACINNMNRqqnmsSSLHLPDKTLQFVRDHPLLEDPVLPignGPRLITKDVNYTQIAVQRVQ 452 zebrafish
NP_001161470 349 QSNTKWVRYNGEVPKPRPGACINNEARamnytSSLNLPDMTLQFVKDHPLMDDSVSPvgnKPKLVLRDVIYTQIVVDRVK 428 western clawed ...
NP_006369    350 QSHTKWVRYNGPVPKPRPGACIDSEARaanytSSLNLPDKTLQFVKDHPLMDDSVTPidnRPRLIKKDVNYTQIVVDRTQ 429 human
XP_002190148 346 QFHIKWVQYNGEIPNPRPGACINNEARasnymSSLNLPDKTLQFVKDHPLMDDSVTPmgdRPRLVKRDVKYTQIVVDRVR 425 zebra finch
XP_424426    336 QSHTKWVRYNGEIPNPRPGACINNEARalnyvTSLNLPDKTLQFVKDHPLMDDSVTPvgdRPRLVKRDVKYTQIVVDRVR 415 chicken

Feature 1                                                                                
3OL2_A       409 ALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSkkgnrFVYAGSnSGVVQAPLA 480 human
XP_003200859 453 ALDNSIHHVIFTATDKGFLHKSVVLENEVHTVEEVQLLKNSEPIKTLLLSTdqsdrFLYAGSdSGVVQSPTA 524 zebrafish
NP_001161470 429 ALDGNSYDIMFLSTDKGILHKAVSQDAEMRIIEEIVLFPHLQPVQTLLLSNkegkrFIYAGSnTGVVQSPLA 500 western clawed frog
NP_006369    430 ALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSkkgnrFVYAGSnSGVVQAPLA 501 human
XP_002190148 426 ALNGTIYDVMFIGTDRGALHKAISYENGMHIIEETQLFPDFEPVQTLLLSSktgrrYLFAASnSGVVQSPVS 497 zebra finch
XP_424426    416 ALNGTIYDVMFISTDQGALHKAISYENGMHIIEETQLFPKFEPVQTLLLSSkksrrYLYAGSnSGVVQSPVA 487 chicken

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