Conserved Protein Domain Family
Sema_3G
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cd11255: Sema_3G 
The Sema domain, a protein interacting module, of semaphorin 3G (Sema3G)
Semaphorin 3G is identified as a primarily endothelial cell- expressed class 3 semaphorin that controls endothelial and smooth muscle cell functions in autocrine and paracrine manners, respectively. It is mainly expressed in the lung and kidney, and a little in the brain. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.
Links
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Statistics
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PSSM-Id: 200516
Aligned: 3 rows
Threshold Bit Score: 988.641
Created: 7-Apr-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Comment:based on the homodimer structure of Semaphorin 3A
  • Comment:Semaphorin/plexin signaling is dependent on the formation of a 2:2 heterotetramer that is composed of two plexin molecules bound to a semaphorin homodimer. Monomeric semaphorin binds plexin but does not trigger signaling.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
XP_003227353  58 FLGHRGILDFRSLYLDEYRDRLFIGGKDTLYSLRLDQTNmDAKEIYWPPLPGQKEECFRKGKDpvtECANFVRVFYPLNR 137 green anole
NP_001116184  42 FNGLHGDLHLSAVFLDEYHDRLFLGGKDVLYSLRLDHTH-DAKEIHWPSLPGNREDCILKGKDpemECANFVRLLQPFNR 120 zebrafish
Q9NS98        49 FLGPQGSLNLQAMYLDEYRDRLFLGGLDALYSLRLDQAWpDPREVLWPPQPGQREECVRKGRDpltECANFVRVLQPHNR 128 human

Feature 1                                                                                        
XP_003227353 138 THLLACGTGAFHPICALIYVGPRGEHVfsldpttiESGRGRCPHEPNRPFASTFVGGDLYTGLTADFLGRDSVIFRTMgh 217 green anole
NP_001116184 121 THLLACGTGAFQPVCAYVNVGHRGEHVfsldqttvQNGRGRCPHDPKLPFASTFTGGELYTGLTADFLGRDSVISRGFgt 200 zebrafish
Q9NS98       129 THLLACGTGAFQPTCALITVGHRGEHVlhlepgsvESGRGRCPHEPSRPFASTFIDGELYTGLTADFLGREAMIFRSGgp 208 human

Feature 1                                                    ##   #  ###                         
XP_003227353 218 rsSLRTEMDQRLLNAPKFVAAYLIPDNDDRDNDKVYFFFTEKAAESE--SKGRAIFSRVGRICANDAGGQRVLVNKWSTF 295 green anole
NP_001116184 201 rsPMRTETDQRILHEPRFVAAHLIPDSADRDDDKIYFFFTERATETAerDDDGAIHTRIGRLCANDVGGQRVLVNKWSTF 280 zebrafish
Q9NS98       209 rpALRSDSDQSLLHDPRFVMAARIPENSDQDNDKVYFFFSETVPSPDg-GSNHVTVSRVGRVCVNDAGGQRVLVNKWSTF 287 human

Feature 1                #  ## # #   #                      ########                         ####
XP_003227353 296 NKARLVCSVPGPDGIDTYFDELEDVFLLrTKDGKSPEIYALFSTISNVFQGFAICVYRMADIWEVFNGPFAHkdgpDHQW 375 green anole
NP_001116184 281 IKARLVCSVPGPHGIQTHFHQLEDVFLLrTKDETNPEIYAIFSTISNVFQGYAVCVYSMADIREAFNGPFAHkegpDYQW 360 zebrafish
Q9NS98       288 LKARLVCSVPGPGGAETHFDQLEDVFLLwPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFNGPFAHrdgpQHQW 367 human

Feature 1                                                       #              #                 
XP_003227353 376 SAYEGKVPYPRPGVCPSKttnqpsrqysSTKDYPDEVLHFARAHPLMSRSVYPLHRRPVLVKTNLQHHLRQIVVDRVEAE 455 green anole
NP_001116184 361 GPYEGRVPYPRPGVCPSKitaqpgrafrSTLEFPDTVLQFARTHPLMWRPVYPSHRQPLLLRTGAPYRLTHITVDRTQAE 440 zebrafish
Q9NS98       368 GPYGGKVPFPRPGVCPSKmtaqpgrpfgSTKDYPDEVLQFARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAE 447 human

Feature 1                                                                                   
XP_003227353 456 DGQYDVMFIGTDSGSILKVISLQRGnfaaaEEVILEELQVFKapVPITEMEISVKRQMLYVGSrvGVAQVKLHHC 530 green anole
NP_001116184 441 DGYYDVMFIGTDIGTVLKVIVLGKGnslagEEITLEEMQVFKvpTPITSMDISVKRQTLFVGSqtAVVQVPLHRC 515 zebrafish
Q9NS98       448 DGTYDVIFLGTDSGSVLKVIALQAGgsaepEEVVLEELQVFKvpTPITEMEISVKRQMLYVGSrlGVAQLRLHQC 522 human

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