Conserved Protein Domain Family
Sema_3F

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cd11254: Sema_3F 
The Sema domain, a protein interacting module, of semaphorin 3F (Sema3F)
Sema3F is coexpressed with semaphorin3B. Both Sema3B and Sema3F proteins are candidate tumor suppressors that are down-regulated in highly metastatic tumors. Two receptor families, the neuropilins and plexins, have been implicated in mediating the actions of semaphorins 3B and 3F. Sema3F is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.
Statistics
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PSSM-Id: 200515
Aligned: 8 rows
Threshold Bit Score: 953.885
Created: 7-Apr-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Comment:based on the homodimer structure of Semaphorin 3A
  • Comment:Semaphorin/plexin signaling is dependent on the formation of a 2:2 heterotetramer that is composed of two plexin molecules bound to a semaphorin homodimer. Monomeric semaphorin binds plexin but does not trigger signaling.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
XP_003210066  48 FNFLLNSSDYRILLKDEDHDRMYVGSKDYVLSLDLHDINrEPLIIHWPASQQRIEECILSGKNsngECGNFIRLIQPWNR 127 turkey
NP_001011157  47 LSFLLNTTDYRILLKDEDHDRMYVGSKDFILSLDLQDINrEPLIIHWPASQQRIEECVLSGKDsngECGNFIRLIQPWNR 126 western clawed ...
NP_001014824  42 FSFSFNTSDYRILHMDQDQGRLYLGSREYLVSLDMRNVNkEPLIIHWPATTQRKGECKLTGKGgqgECANFVRLIEPWNR 121 zebrafish
NP_001121263  44 FTFGFNTSDYRILLLDQDQDRMYVGSRDYVLSLDLGNINrEPLIIHWPAPLNRHKECLMAGRGradECYNYLRVIQPLNR 123 African clawed ...
XP_001921106  48 FSFLLNTSDYRILRMDEDHDRMYVGSKDYILSLDLHDINrEPLIIHWPVSPQRKTECVLSGKDtngECGNFIRLIEPWNR 127 zebrafish
XP_003215778  39 FSFAFNTSDYRILLVDQDQERLYLGARDFLVALDLHNINkEPLIIHWPALPTHQNECRLAGKGqrgECFNYIRLMEPLNR 118 green anole
NP_989589     48 FNFLLNSSDYRILLKDEDHDRMYVGSKDYVLSLDLHDINrEPLIIHWPASQQRIEECILSGKNsngECGNFIRLIQPWNR 127 chicken
O88632        48 FNFLLNTTDYRILLKDEDHDRMYVGSKDYVLSLDLHDINrEPLIIHWAASPQRIEECILSGKDgngECGNFVRLIQPWNR 127 house mouse
Feature 1                                                                                        
XP_003210066 128 THLYVCGTGAYNPICAFINRGRkaqdyif-------------------------------ylepdklESGKGKCSYDPKV 176 turkey
NP_001011157 127 THLYVCGTGAYNPVCTYINRGRkaqdyvf-------------------------------ylepdrvESGKGKCAYDPKL 175 western clawed ...
NP_001014824 122 THLYTCGTGAYKPICTFINRGWraeeylf-------------------------------rlvpgyvDSEKGKSPYDPRQ 170 zebrafish
NP_001121263 124 THLYACGTGAYQPQCAVIYRGWrsedymf-------------------------------rivpsslESGKGRCPYDPKQ 172 African clawed ...
XP_001921106 128 THLYICGTGAYNPVCTYVNRGRkpmtamhlqmpqtrgrasraae-petvfdetglqeyvfhlepgkeDSGKGKCPYDPKL 206 zebrafish
XP_003215778 119 THIYACGTGAYHPVCALINRGWrseeylf-------------------------------rmvprsmEPGKGKCSYDPRQ 167 green anole
NP_989589    128 THLYVCGTGAYNPICAFINRGRkaqdyif-------------------------------ylepdklESGKGKCSYDPKV 176 chicken
O88632       128 THLYVCGTGAYNPMCTYVNRGRraqalpwtqmqvvrgrgsratdgadrptptaprqdyifylepeklESGKGKCPYDPKL 207 house mouse
Feature 1                                                                                     ## 
XP_003210066 177 DTVSALINEELYAGVYIDFMGTDAAIFRTMgkqtaMRTDQYNSRWLNDPAFVRAQLIPDSSERNDDKLYFFFREKSADA- 255 turkey
NP_001011157 176 DSVSALINEELYSGVYIDFMGTDAAIFRAMgkqaaMRTDQYNSRWLNDPAFVHVHLIPDSADRNDDKLYFFFREKSTDS- 254 western clawed ...
NP_001014824 171 ENAAALINGNLYSGVHVDFMGTDPAIFRTLgdrpaVRTEQYDSRWLNEPVFIKIQKVPDSAEKNDDKLYFFFREKSLDAs 250 zebrafish
NP_001121263 173 ENMATLIDGVLYAGVQVDYMGTDSAIFRTMghkppIRTEQYDSRWLNDPLFVGSLVVSESSFKEDDKLYILFRERSLEG- 251 African clawed ...
XP_001921106 207 NSVSALINGELYAGVYIDFMGTDSAIFRTLgknavMRTDQYNSRWLNDPSFVHVHLIPDSGEKNDDKLYFFFREKSSEM- 285 zebrafish
XP_003215778 168 HSMAVLVNNTLYAGVHVDFMGTDAALFRTMgprpaVRTEQHDSRWLYDPVFLQAHVIPDSSDHNDDKLYFFFREKALEG- 246 green anole
NP_989589    177 DTVSALINEELYAGVYIDFMGTDAAIFRTMgkqtaMRTDQYNSRWLNDPAFVRAQLIPDSSERNDDKLYFFFREKSADA- 255 chicken
O88632       208 DTASALINEELYAGVYIDFMGTDAAIFRTLgkqtaMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEA- 286 house mouse
Feature 1         #  ###                                 #  ## # #   #                      #####
XP_003210066 256 -PLSPGVYSRIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGPDGIETHFDELQDVFIQqTQDTKNPVIYAVFSASGSV 334 turkey
NP_001011157 255 -PHSPTVYSRIGRVCLNDDGGHCCLVNKWSTFLKARLICSVPGADGIETHFDELQDVFIQqTQDNKNPVIYAVFSSSGSV 333 western clawed ...
NP_001014824 251 gGSAPSVLARVGRVCLNDDGGQRSLVNKWTTFLKARLVCSVIGADGVETYFDELRDVFIQrTHDERNPIVYAVFSTAGSV 330 zebrafish
NP_001121263 252 -ENGPAVLSRIARVCLNDEGGLRSLVGKWTSYLKARLVCSVIGQDGVETSFDQLRDVFIQpTHDKQNPLIYGVFTTLGSV 330 African clawed ...
XP_001921106 286 -GQSPKSQSRIGRICLNDDGGHCCLVNKWSTFLKARLICSVPGADGIETHFDELRDVYIQpTQDTKNPVIYGVFSVSGSV 364 zebrafish
XP_003215778 247 -AVGPAVLARVGRVCLNDDGGQRSLVNKWTTFLKARLVCSVIGEDGVETFFDELRDVFLLpTQDEKHPLVYGVFSTLGSV 325 green anole
NP_989589    256 -PLSPGVYSRIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGPDGIETHFDELQDVFIQqTQDTKNPVIYAVFSASGSV 334 chicken
O88632       287 -PQNPAVYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQqTQDVRNPVIYAVFTSSGSV 365 house mouse
Feature 1        ###                         ####                                            #   
XP_003210066 335 FKGSAVCVYSMADIRMVFNGPFAHKegpNYQWMPYTGKMPYPRPGTCPGGTFTPsmksTKDYPDEVINFMRSHPLMYHAV 414 turkey
NP_001011157 334 FKGSAVCVYSMSDIRMVFNGPFAHKegpNYQWMPYTGKIPYPRPGTCPGGTFTPsmksTKDYPDEVINFMRTHPVMYNPV 413 western clawed ...
NP_001014824 331 FKGSAVCVYSMSDIRNVFNGPFSHKhghNYQWTPYTGKIPYPRPGTCPGGTFTPdlhtTKAFSDEAVNFVRAHPLMYQPI 410 zebrafish
NP_001121263 331 FRGSAVCVYSLADVRAAFNGPFAHKeghGYQMTAYSGKTPYPRPGACAGGFSVPrnrsSRNFGEDVLRFVRTHPLMYSSV 410 African clawed ...
XP_001921106 365 FKGSAVCVYSMADIRMVFNGPFAHKegpNYQWVAYTGKIPYPRPGTCPGGTFTPnmksTKDYPDEVINFMRNHPTMYNSV 444 zebrafish
XP_003215778 326 FRGSAVCVYSMADIRTVFNGPFAHKeghNYQWGSYTGRVPYPRPGACPGGTFTPglrsTREFPDDLVTFVRAHPLMYNAV 405 green anole
NP_989589    335 FKGSAVCVYSMADIRMVFNRPFAHKegpNYQWMPYTGKMPYPRPGTCPGGTFTPsmksTKDYPDEVINFMRSHPLMYHAV 414 chicken
O88632       366 FRGSAVCVYSMADIRMVFNGPFAHKegpNYQWMPFSGKMPYPRPGTCPGGTFTPsmksTKDYPDEVINFMRTHPLMYQAV 445 house mouse
Feature 1                   #                                                                    
XP_003210066 415 YPAHRQPLVVRTNVNYRFTTIAVDQVDAADGRYEVLFLGTDRGTVQKVIVLPRDdmetEELMLEEIEVFKVPAPIKVMTI 494 turkey
NP_001011157 414 YPVHRQPLLVRTNVNYRFTTIAVDQVDASDGRYEVLFLGTDKGTVQKVIVLPKDdletEELILEEVEVFKVPAPIKSMKI 493 western clawed ...
NP_001014824 411 YPIHKRPLVVRTGVGYRFTTIAVDLVDAVDGRYEVLFLGTDRGTVQKVIVLPKDisttEELILEEVEVFKTPAAVKTLKI 490 zebrafish
NP_001121263 411 YPVNRRPLLLLSDASYTYTSIAVDRVPAADGEYTVLFLGTDRGTVQKVMILPRGtketESITLEEVEVFKVPSPIRNLRI 490 African clawed ...
XP_001921106 445 YPVHKRPLVVRTNVDYEFTTITVDQVTAADGNYEVLFLGTDRGTVQKVIVLPSDdlqtEELVLEEVEVFKVPTSITTMKI 524 zebrafish
XP_003215778 406 YPLQRRPLLVRTNVPYSFTTLAVDLVDAVDGRYEVLFLGTDQGTVQKVIVLPKEqgvlEELTLEEVEVFRVPSPVKTLWI 485 green anole
NP_989589    415 YPAHRQPLVVRTNVNYRFTTIAVDQVDAADGRYEVLFLGTDRGTVQKVIVLPRDdmetEELMLEEIEVFKVPAPIKMMTI 494 chicken
O88632       446 YPLQRRPLVVRTGAPYRLTTVAVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDdqevEELMLEEVEVFKEPAPVKTMTI 525 house mouse
Feature 1                               
XP_003210066 495 SSKRQQLYVSSavGVTHLALHRC 517 turkey
NP_001011157 494 STKRQQLYVASmsGVTHVALHRC 516 western clawed frog
NP_001014824 491 STKRQQLYVSSerGLTQVSLHRC 513 zebrafish
NP_001121263 491 SSKRHQLYVSSdvGVTQLSLHRC 513 African clawed frog
XP_001921106 525 SSKRQQLYVASavGVTHMALHRC 547 zebrafish
XP_003215778 486 SSKRQQLYVSSdvGVSQLSLHRC 508 green anole
NP_989589    495 SSKRQQLYVSSavGVTHLALHRC 517 chicken
O88632       526 SSKRQQLYVASavGVTHLSLHRC 548 house mouse

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