Conserved Protein Domain Family
Sema_3E
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cd11253: Sema_3E 
The Sema domain, a protein interacting module, of semaphorin 3E (Sema3E)
Sema3E is a secreted molecule implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. It is also highly expressed in metastatic cancer cells. Sema3E signaling, through its high affinity functional receptor Plexin D1, drives cancer cell invasiveness and metastatic spreading. Sema3E is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.
Links
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Statistics
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PSSM-Id: 200514
Aligned: 4 rows
Threshold Bit Score: 936.196
Created: 7-Apr-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Comment:based on the homodimer structure of Semaphorin 3A
  • Comment:Semaphorin/plexin signaling is dependent on the formation of a 2:2 heterotetramer that is composed of two plexin molecules bound to a semaphorin homodimer. Monomeric semaphorin binds plexin but does not trigger signaling.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
O15041        49 FHSPFGFLDLHTMLLDEYQERLFVGGRDLVYSLSLERISdGYKEIHWPSTALKMEECIMKGKDagECANYVRVLHHYNRT 128 human
O42237        53 FHSPFGYLGLHIMLLDEYQERLFVGGRDLLYSLSLDRISnNYREIHWPSTPLQAEECIIKGRDadECANYVRVLHRYNRT 132 chicken
NP_001038549  46 FQAGEGRLQQYTMLLDETQERLIIGGKDVLYSLNLERITaPHKRIVWSSSQEQVEDCLMQGREkpECANYIKLVQHYNST 125 zebrafish
XP_002935302  52 SVFHSPFLDLNIMYLDEYQERLFVGGRNLLYSLSLEQVSeNYKEIHWPSTDQQVEDCSRKGRDksECANFIRVLHHYNRT 131 western clawed ...

Feature 1                                                                                        
O15041       129 HLLTCGTGAFDPVCAFIRVGyhled-plfhLESPRSERGRGRCPFDPSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMg 207 human
O42237       133 HLLACGTGAFDPVCTFIRVGhpsed-hlfqLESHKFERGRGRCPFDPTSSFTSILIGGELFTGLYSDYWGRDAAVFRTMn 211 chicken
NP_001038549 126 HLLACGTGAFSPVCAYIRVSrgaeqerefrLESDHIESGRGRVPFHPNSPLASTVYRGELFVGLYTDYWENDAALYRLGn 205 zebrafish
XP_002935302 132 HLLACGTGAFDPVCAFIRAGlrsqe-hlfqLEPQKFERGRGRCPFDPNSSVISTLTGGELFVGLYNDFWGRDATIFRTTg 210 western clawed ...

Feature 1                                                      ## #  ###                         
O15041       208 rlahIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGGQRILVNKWSTF 287 human
O42237       212 rmahLRTEPDSEHLLKEPKFVGSYMIPDNEDHDDNKVYLFFTEKALEAETSTHAIYTRVGRVCVNDMGGQRIVVNKWSTF 291 chicken
NP_001038549 206 h-sfIRTEVGDRQQLNEPKFVGSAVIPDNDDPADDKVYYFFTERVADVEGGNKAVYTRVARVCANDQGGQRMLVNRWSSF 284 zebrafish
XP_002935302 211 hlppIRTEHDDDRILTEPKFVGSYMIPDNEDKDDNKMYFFYTEKAIEGDKGVQAIYSRVGRVCANDIGGQRMMVNKWTTF 290 western clawed ...

Feature 1                #  ## # #   #                      ########                         ####
O15041       288 LKARLVCSVPGMNGIDTYFDELEDVFLLpTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAFNGPYAHkegpEYHW 367 human
O42237       292 LKTRLVCSVPGRNGIDTHFDELEDVFLLqTRDNKNPVIFGLFSTTSNIFRGYAICVYHMAIVRAAFNGPYAHkegpEYYW 371 chicken
NP_001038549 285 LKTRLICSVAGPNGIDTHFDELEDVFVLrKKDEKNPEIFGLFSTTSAVFKGYAVCMYNMDDIRAAFNGPFAHrertDHHW 364 zebrafish
XP_002935302 291 LKTRLICSVPGPNGIDTFFDELEDVFLLhTRDNKNPEIFALFSTTSNIFKGYAICVYHMASIREAFNGPFAHkegpEYHW 370 western clawed ...

Feature 1                                                    #              #                    
O15041       368 SVYEGKVPYPRPGSCASKvnggrygtTKDYPDDAIRFARSHPLMYQAIKPAHKKPILVKTDGKYNLKQIAVDRVEAEDGQ 447 human
O42237       372 ALYEGKVPYPRPGSCASKvngglyttTKDYPDEAVHFARSHPLMYQPIKPVHKRPILVKTDGKYNLKQIAVDRVEAEDGQ 451 chicken
NP_001038549 365 KVYDGKVPYPRPGSCASKingghfssSKEYSDEVLRFARSHPLMFQAVQPVHRRPILLDTEGGRKLTQLAVDRVEAEDGH 444 zebrafish
XP_002935302 371 SIYEGKIPYPRPGLCASKvngghygtTKDYPDEALRFARSHPLMYESVKPTHKKPILIKADGKYNLKQIAVDRVEAEDGQ 450 western clawed ...

Feature 1                                                                                
O15041       448 YDVLFIGTDNGIVLKVITIYNQEmesmEEVILEELQIFKdpVPIISMEISSKRQQLYIGSasAVAQVRFHHC 519 human
O42237       452 YDVLFIGTDNGIVLKVITIYNQEtesmEEVILEELQVFKvpIPILSMEISSKRQQLYIGTesVIAQVKFHQC 523 chicken
NP_001038549 445 YNVLFIGTDNSVVLKMITIYNKEadtvEEVLLEELQVFKvpVPITEILISTKRQQLYVGSelGVTQIRVHQC 516 zebrafish
XP_002935302 451 YHVVFIGTDNGIVLKVITIYNQEtetmEEVILEELQVFKvpDPIISMEISAKRQQLYIGSasSIVQIKTHQC 522 western clawed frog

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