Conserved Protein Domain Family
Sema_3D
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cd11252: Sema_3D 
The Sema domain, a protein interacting module, of semaphorin 3D (Sema3D)
Sema3D is a secreted semaphorin expressed during the development of the nervous system. In zebrafish, Sema3D is expressed in the ventral tectum. It guides retinal axons along the dorsoventral axis of the tectum and guides the laterality of retinal ganglion cell (RGC) projections. Both Sema3D knockdown or its ubiquitous overexpression induced aberrant ipsilateral projections. Proper balance of Sema3D is needed at the midline for the progression of RGC axons from the chiasm midline into the contralateral optic tract. Sema3D is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.
Links
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Statistics
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PSSM-Id: 200513
Aligned: 4 rows
Threshold Bit Score: 1018.68
Created: 7-Apr-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Comment:based on the homodimer structure of Semaphorin 3A
  • Comment:Semaphorin/plexin signaling is dependent on the formation of a 2:2 heterotetramer that is composed of two plexin molecules bound to a semaphorin homodimer. Monomeric semaphorin binds plexin but does not trigger signaling.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
NP_689967     61 FLGSSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLAGKDaNTECANFIRVLQPYNK 140 human
Q90663        49 FLGSTEGLDFRTLLLDEERGRLLVGAKDHIFLLNLVDLNKNVKKIYWPAAKEKMELCKLAGKDaHTDCANFIRVLQPYNR 128 chicken
NP_001087589  60 LHPVTEGRAFQTLLLDEERGKLLLGAKDHIYLLDLVDLNKNLRKIHWPAAKEKIEFCKRAGKDnNLECANFIKVLHHYNK 139 African clawed ...
NP_571123     65 FTGSSEGQHFQTVLLDEERSRLLLGAKDHVYLLDPDNINKHPKKLSWPASRDRVEMCILAGKNpLTECANFIRVLHSYNR 144 zebrafish

Feature 1                                                                                        
NP_689967    141 THIYVCGTGAFHPICGYIDLGVYKEdiifkLDTHNLESGRLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLG 220 human
Q90663       129 THVYVCGTGAFHPLCGYIELGTHKEetifrLDTQNLESGRLKCPFDPQQPFASVMADEYLYAGTASDFLGKDTALTRSLG 208 chicken
NP_001087589 140 THAYTCGTGAFHPVCGYIELGTPKEevvfqLDIQNLESGRLKCPFDPQPPFASIMTDEYLFAGTASDFLGKETTFTRSMG 219 African clawed ...
NP_571123    145 THVYACGTGAFHPTCAFLEIKGHKEdrwllLHSNTMESGRMKCPFDPNQPFASVLTDQYLYAGTASDFLGKDSTFTRSLG 224 zebrafish

Feature 1                                                         ## #  ###                      
NP_689967    221 PTHDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKW 300 human
Q90663       209 PSHDHHYIRTDISEHYWLTGAKFIATFPIPDTYNPDDDKIYFFFREISQDSSTSDKTILSRVGRVCKNDMGGQRSLINKW 288 chicken
NP_001087589 220 PTPDHHFIKTDTDDHYWLNGAKFFGTYAIPDTYNPDDDKIYFFFREAHPEGSFSEKSVFSRVGRVCKNDIGGQRSLINKW 299 African clawed ...
NP_571123    225 PPPHQQYIRTDISEDYWINEGKFISAHPISDTYNPDDDKIYFFFREASRDGSTTDKSVLSRVARICRNDVGGLRSLTNKW 304 zebrafish

Feature 1                   #  ## # #   #                      ########                         #
NP_689967    301 TTFLKARLICSIPGSDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCVYSMADIRAVFNGPYAHKESAD 380 human
Q90663       289 TTFLKARLVCSIPGPEGADTHFDELQDIFLLSTRDERNPLVYGVFTTTSSVFKGSAVCVYSMADIRAVFNGPYAHKESAD 368 chicken
NP_001087589 300 TTFLKARLVCSIPGQDGGDTYFDELQDIFLLPTKDERNPVVYGIFTTTSSIFKASAVCVYSMADIRGVFNGPYAHKESPD 379 African clawed ...
NP_571123    305 TTFLKARLVCSIPGPDGVDTHFDELQDIFLLPSRDEKNPMVYGVFTTTSSIFKGSAVCVYTMEDIRAAFNGPYAHKEGPD 384 zebrafish

Feature 1        ###                                            #              #                 
NP_689967    381 HRWVQYDGRIPYPRPGTCPSKTYDPLIKSTRDFPDDVISFIKRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAE 460 human
Q90663       369 HRWVQYEGRIPYPRPGTCPSKTYDPLIKSTRDFPDEVISFIKRHPLMYKSVYPLTGGPVFTRINVDYRLTQIVVDHVMAE 448 chicken
NP_001087589 380 HRWVQYDGRIPYPRPGTCPSKTYDPTIKSTKDFPDDVISFSKNHPLMYKAIYPLHGKPVFTRLNVDYKLTQIAVDQVVAE 459 African clawed ...
NP_571123    385 HRWVEYEGRIPYPRPGTCPSRTYDPHIKTTKDFPDEVISFIRLHPLMYQSVHPMTGRPIFTRINTEYRLTQIIVDRVAAE 464 zebrafish

Feature 1                                                                                  
NP_689967    461 DGQYDVMFLGTDIGTVLKVVSISKEkWNMEEVVLEELQIFKHSSIILNMELSLKQQQLYIGSrdGLVQLSLHRC 534 human
Q90663       449 DGQYDVIFLGTDIGTVLKAVSITKEkWTKEEVVLEELQIFKHPSFISTMEISQKQQQLYIGSrdGLVQLSLHRC 522 chicken
NP_001087589 460 DGQYDVMFLGTDVGTVLKVISVAKDiWTMEEVLLEEMQIFKQPEAITNIELSLKQQQLYITSkdGLVQLSLHRC 533 African clawed frog
NP_571123    465 DGQYAVMFLGTDMGSVLKVVSITQEnWSSEEIILEELQVFKNPSPILNMEVSSKQQQLFVGGsdGLVQVSLHRC 538 zebrafish

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