Conserved Protein Domain Family
Sema_plexin_C1
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cd11246: Sema_plexin_C1 
The Sema domain, a protein interacting module, of Plexin C1
Plexins serve as semaphorin receptors. Plexin C1 has been identified as the receptor of semaphorin 7A, which plays regulation roles in both the immune and nervous systems. Unlike other semaphorins which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Plexin C1 is a potential tumor suppressor for melanoma progression. The expression of Plexin C1 is diminished or absent in human melanoma cell lines. Cofilin, an actin-binding protein involved in cell migration, is a downstream target of Sema7A-Plexin C1 signaling. Cofilin is not phosphorylated when Plexin C1 expression is silenced. Thus, melanoma invasion and metastasis may be promoted through the loss of Plexin C1 inhibitory signaling on cofilin activation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
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Statistics
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PSSM-Id: 200507
Aligned: 5 rows
Threshold Bit Score: 622.693
Created: 6-Jun-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_005752      44 QAIGAIAASQEDGVFVASGSCLDQLDYSLEHSLSr-LYRDQAGNCTEPVSLAP-PARPRPGSSFSKLLLPY-REGAAGLG 120  human
NP_061267      44 QAIGAIAASRADGVFVASGSCLDQLDYSLKNRLSr-LYRDQAGNCTEPVSLAP-PARPRPGSSFSKLLLPY-REGATGLE 120  house mouse
AAN84620       44 QAIGAIAASRADGVFVASGSCLDQLDYSLKNRLSr-LYRDQAGNCTEPVSLAP-PARPRPGSSFSKLLLPY-REGATGLE 120  house mouse
XP_002189112   32 SQQTKPYAGSLTSSLLAQGGIGLLVDGSFELLGAp-IDNIEVSGGAVLVAGGScLYELGPDLQPRRRVVPAvGQGCGEPP 110  zebra finch
XP_003221124   14 SSLSWTALALASSSPPPSPPVLSFPSAIDSLAVAggKLLVASGPCWYDVSPSL-SSKAVGRCQEARNATNSlLLPFGDES 92   green anole

NP_005752     121 GLLLTGWTF--DRGACEVRPLg--nLSRNSLRngTEVVSCHPQGSTAGVVYra----------grNNRWYLAVAATYVLP 186  human
NP_061267     121 GLLLTGWTF--DRGACEVRPLg--nLNRSSLRngTEVVSCHPQGSTAGVVYra----------sgTDLWYLAVAATYVLP 186  house mouse
AAN84620      121 GLLLTGWTF--DRGACEVRPLg--nLNRSSLRngTEVVSCHPQGSTAGVVYra----------sgTDLWYLAVAATYVLP 186  house mouse
XP_002189112  111 GMRSNLLLHyeEAGGVGVLLTgwtqDGGACQV--WEQPSYRQRLNQSEVVSclpdgstagvvfqqAGAWYLAVAATYSTS 188  zebra finch
XP_003221124   93 RLLLTCWTRpgCLCLLEDRVL----GPGASQTfgQELVSALPGVSSAGLMLfn----------nrSGGEWFLVVATSHKR 158  green anole

NP_005752     187 EPETASRCNPAASDHDTAIALKDTEGRSLATQELGRLKLCegaGSLHFVDAFLWNGSIYFPYYPYNYTsGAATGWPSMAR 266  human
NP_061267     187 EPETANRCNPAASDRDTAIALKNTEGRSLATQELGRLKLRgsaGSLHFVDAFLWNGSVYFPYYPYNYTsGAATGWPSMAR 266  house mouse
AAN84620      187 EPETANRCNPAASDRDTAIALKNTEGRSLATQELGRLKLRgsaGSLHFVDAFLWNGSVYFPYYPYNYTsGAATGWPSMAR 266  house mouse
XP_002189112  189 ADTNHLHCEPSKSDKETVITVRSMVNLKSKEELGIIKRRE---EPLHFVDALQWGDHLFFPYYTLKAR-LGNNTEPPSMA 264  zebra finch
XP_003221124  159 PDGPASACGDSGSSLGLSVANHAVFIVGERKRKVLDGQVL---SVAGEQFLNFSAALLWKGLYFFPYFhRNLSLEPKMLV 235  green anole

NP_005752     267 IAQSTEVLFQGQASLDCGHGHPDGRRLLLSSSLVEALDVWAGVFSAaaGEGQERRSPTTTALCLFRMSEIQARAKRvswd 346  human
NP_061267     267 IAQSTEVLFQGQAALDCDHGHPEGRRLLLSSSLVEAVDIWAGVFSAatGEGQERRSPATTALCLFRMSEIQAHARScswd 346  house mouse
AAN84620      267 IAQSTEVLFQGQAALDCDHGHPEGRRLLLSSSLVEAVDIWAGVFSAatGEGQERRSPATTALCLFRMSEIQAHARScswd 346  house mouse
XP_002189112  265 VLHQLRPSDGGLTLRGHVYLDCGCRSLIISSSLVRQDQRGWWVGVF--RHSHSTKAWNSTAVCIFGMEEMKEKACAs--- 339  zebra finch
XP_003221124  236 VEHKLADNQLSALGQAALRCGDRGRILSSSLLEPRGLWVGLFGAAQ--EGEPGATAVCLFPLQRIRREIQACRFNGet-- 311  green anole

NP_005752     347 fktaeshckegDQPERVq--PIASS-----TLIHSDLTSVYGTVVMNRTVLFLGTGDGQLLKVILGenltsNCPEVIYEI 419  human
NP_061267     347 fqatehnckegDRPERVq--PIASS-----TLIHSDLTSVYGTVVMNRTVLFLGTGDGQLLKVVLGenltsNCPEVIYEI 419  house mouse
AAN84620      347 fqatehnckegDRPERVq--PIASS-----TLIHSDLTSVYGTVVMNRTVLFLGTGDGQLLKVVLGenltsNCPEVIYEI 419  house mouse
XP_002189112  340 -----------THFNMNgksCEAPSikklpTLIHSGLVAVYGTVVLNHIVLFLGTDDGQLLKAILNedmksNCPEVLYEI 408  zebra finch
XP_003221124  312 ----------kEFPELCt-vPAWPLnn-ltSLNHSSLVSVYATIVLNKTVLFLGTTNGQLLKVILDdhmnpNCPEILYEI 379  green anole

NP_005752     420 KEETPVFYKLVPDPvKNIYIYLTAGKEVRRIRVA 453  human
NP_061267     420 KEETPVFYKLVPHPmKNIYIYLTAGKEVRRIPVA 453  house mouse
AAN84620      420 KEETPVFYKLVPHPmKNIYIYLTAGKEVRRIPVA 453  house mouse
XP_002189112  409 EEETSIFPKLRLDPvNNNYIYLSSANKVRRIPVA 442  zebra finch
XP_003221124  380 KEESAVFHQLEFDPvNEDYIYLPSNNKIRRIKVA 413  green anole
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