3OKW,3OL2,1Q47,3OKY


Conserved Protein Domain Family
Sema_semaphorin

?
cd11235: Sema_semaphorin 
Click on image for an interactive view with Cn3D
The Sema domain, a protein interacting module, of semaphorins
Semaphorins are regulator molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. They can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted proteins; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. The semaphorins exert their function through their receptors, the neuropilin and plexin families. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.
Statistics
?
PSSM-Id: 200496
Aligned: 10 rows
Threshold Bit Score: 530.059
Created: 26-May-2011
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
plexin bindinghomodimer
Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:plexin binding site [polypeptide binding site]
Evidence:
  • Structure:3OKY; Mouse Semaphorin 6A binds Plexin A2; contacts at 4A.
  • Structure:3OL2; Human Semaphorin 4D binds its receptor Plexin B1, contacts at 4A distance.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                   ####                  
3OKW_A         41 LDIQMIMIMnr---tLYVAARDHIYTVDIdtshteeiycsKKLTWKSrq---aDVDTCRMKGkhk-deCHNFIKVLLKKn 113  house mouse
3OL2_A         27 YNYSALLLSedk-dtLYIGAREAVFAVNAlnis----ekqHEVYWKVse---dKKAKCAEKGkskqteCLNYIRVLQPLs 98   human
1Q47_A         30 SSYHTFLLDeer-srLYVGAKDHIFSFNLvni-----kdfQKIVWPVsy---tRRDECKWAGkdilkeCANFIKVLEAYn 100  house mouse
Q26473         47 HKDHFKLLEkdh-nsLLVGARNIVYNISLrdlt---efteQRIEWHSsg---aHRELCYLKGkse-ddCQNYIRVLAKId 118  American gras...
Q24323         66 LYYRTFHMNedr-dtLYVGAMDRVFRVNLqnis---ssncNRDVINLept-rdDVVSCVSKGksqifdCKNHVRVIQSMd 140  fruit fly
EFZ11332       95 TSSRHLLQA------VAFLGRDNLYRLTLtsl------tdLEHASWSap--edKVNTCQNKGqsv-edCRNYVKVLLSNg 159  red fire ant
O75326         72 TEPHTVLFHepgsssVWVGGRGKVYLFDFp---------eGKNASVRtvnigsTKGSCLDKRd-----CENYITLLERRs 137  human
NP_001161655   43 NITLSKVLDnr---yLYVGSVDRFFLRDMesd------feLKADIPWqpd-dsDRDFCKLMHvd--teCHNFIKVIEKNd 110  Saccoglossus ...
XP_003378654   51 LKNAHKIKHta--acVHACMYERSGLITLdsl-----vilQRVDVPAss---dQIDRCYGGGkdkvkdCRNFIRMIAQEs 120  Trichinella s...
3OKY_B         41 LDIQMIMIMnr---tLYVAARDHIYTVDIdtshteeiycsKKLTWKSrq---aDVDTCRMKGkhk-deCHNFIKVLLKKn 113  house mouse
Feature 1                                                  ##   #                           # ##  
3OKW_A        114 d-dTLFVCGTNAfnPSCRNYrvdtlet-------fgdefsGMARCPYDAkhANIALFAdg-------kLYSATVTDFLai 178  house mouse
3OL2_A         99 a-tSLYVCGTNAfqPACDHLnltsfkf-------lgknedGKGRCPFDPahSYTSVMVdg-------eLYSGTSYNFLgs 163  human
1Q47_A        101 q-tHLYACGTGAfhPICTYIevghhpednifklqdshfenGRGKSPYDPklLTASLLIdg-------eLYSGTAADFMgr 172  house mouse
Q26473        119 d-dRVLICGTNAykPLCRHYalkdgdy------vvekeyeGRGLCPFDPdhNSTAIYSeg-------qLYSATVADFSgt 184  American gras...
Q24323        141 qgdRLYVCGTNAhnPKDYVIyanlthlpr--seyvigvglGIAKCPYDPldNSTAIYVengnpgglpgLYSGTNAEFTka 218  fruit fly
EFZ11332      160 --kSLFTCGTYAfsPWCAWReienits-------vtsemsGVAMCPYSPhaNVTALLSrgp----sggLFAGAPTDFSga 226  red fire ant
O75326        138 --eGLLACGTNArhPSCWNLvngtv----------vplgeMRGYAPFSPdeNSLVLFEgd-------eVYSTIRKQEYng 198  human
NP_001161655  111 endKLLVCGTNAyvPSCRYYddytiqnt-----eefgvttGLYKSPNHPgpLNTAIFAng-------sLYVGTASTATk- 177  Saccoglossus ...
XP_003378654  121 n-nSLLICSTGAfrPTCSIRnmenfnl-------igkiedGIGYAPYDPn-YSLAYVIten-----rqVIVGVSLNFVgt 186  Trichinella s...
3OKY_B        114 d-dTLFVCGTNAfnPSCRNYrvdtlet-------fgdefsGMARCPYDAkhANIALFAdg-------kLYSATVTDFLai 178  house mouse
Feature 1             #                 #  ## #    #                               #              
3OKW_A        179 daVIYRSLgds--------ptLRTVKHdSKWLKEPYFVQAVDYG----------DYIYFFFREIAVEYnTMGKVVFPRVA 240  house mouse
3OL2_A        164 epIISRNSsh---------spLRTEYA-IPWLNEPSFVFADVIRkspdspdgedDRVYFFFTEVSVEYeFVFRVLIPRIA 233  human
1Q47_A        173 dfAIFRTLghh--------hpIRTEQHdSRWLNDPRFISAHLIPesdn---pedDKVYFFFRENAIDGeHSGKATHARIG 241  house mouse
Q26473        185 dpLIYRGP-------------LRTERSdLKQLNAPNFVNTMEYN----------DFIFFFFRETAVEYiNCGKAIYSRVA 241  American gras...
Q24323        219 dtVIFRTDlyntsakrleykfKRTLKYdSKWLDKPNFVGSFDIG----------EYVYFFFRETAVEYiNCGKAVYSRIA 288  fruit fly
EFZ11332      227 dpAIYRTLas---------pnLRTRQYdSKWLNDPQFVGSFETE----------DHVYFLFRESAVEYiNCGKKIYSRIA 287  red fire ant
O75326        199 kiPRFRRIr-----------gESELYTsDTVMQNPQFIKATIVHqdq----aydDKIYYFFREDNPDKnPEAPLNVSRVA 263  human
NP_001161655  178 -sVIARSVekddl----lqtdLKTEDSdSRWLNEPDFISSFDIG----------QEVFFFLREIAMEYsNYGKIVYSRVA 242  Saccoglossus ...
XP_003378654  187 deAIVRIRpank------qlrTMKNDKfTLNGIEPHFVAAFEIG----------PFVYFFFHEIAIEHfSHRQIRYSRVA 250  Trichinella s...
3OKY_B        179 daVIYRSLgds--------ptLRTVKHdSKWLKEPYFVQAVDYG----------DYIYFFFREIAVEYnTMGKVVFPRVA 240  house mouse
Feature 1                  #### # #                                                               
3OKW_A        241 QVCKNDMGGSQRVlEKQWTSFLKARLNCSVPg--dSHFYFNILQAVTDViri----ngrDVVLATFSTPYnsiPGSAVCA 314  house mouse
3OL2_A        234 RVCKGDQGGLRTL-QKKWTSFLKARLICSRPd---SGLVFNVLRDVFVLrspg---lkvPVFYALFTPQLnnvGLSAVCA 306  human
1Q47_A        242 QICKNDFGGHRSL-VNKWTTFLKARLICSVPgpngIDTHFDELQDVFLMnskd---pknPIVYGVFTTSSnifKGSAVCM 317  house mouse
Q26473        242 RVCKHDKGGPHQF-GDRWTSFLKSRLNCSVPg--dYPFYFNEIQSTSDIiegnyggqveKLIYGVFTTPVnsiGGSAVCA 318  American gras...
Q24323        289 RVCKKDVGGKNLL-AHNWATYLKARLNCSISg--eFPFYFNEIQSVYQLps------dkSRFFATFTTSTnglIGSAVCS 359  fruit fly
EFZ11332      288 RVCKNDRGGQIMM-KDVWTTFSKARLNCSLPg--eFPFYYDEIQGAAYHpe-------eGIIYATFTTPIngiAGSAICA 357  red fire ant
O75326        264 QLCRGDQGGESSLsVSKWNTFLKAMLVCSDAa---TNKNFNRLQDVFLLpdpsg-qwrdTRVYGVFSNPW---NYSAVCV 336  human
NP_001161655  243 KVCKKDQGGSDHVlENIWTTFLKARIICSFPg--eFPFYFNNIQDTFKIsyeei-gkttNIFYAVFTTPKnaiPGSAICA 319  Saccoglossus ...
XP_003378654  251 RLCKNDTGASKGIyAQAWTSFLKSRLICQEM----DKVIYDIVQDVQFLps-------eKIFYAIFTSSEvqlPGSAVCV 319  Trichinella s...
3OKY_B        241 QVCKNDMGGSQRVlEKQWTSFLKARLNCSVPg--dSHFYFNILQAVTDViri----ngrDVVLATFSTPYnsiPGSAVCA 314  house mouse
Feature 1                                                                     #   #  #            
3OKW_A        315 YDMLDIANVFt-GRFKEqkspdstwtpvpdervpkpr---pgccagssslekyatsnefpDDTLNFIKTHPLMDEAVPsi 390  house mouse
3OL2_A        307 YNLSTAEEVFshGKYMQsttveqshtkwvryngpvpkprpgacidsearaanytsslnlpDKTLQFVKDHPLMDDSVTpi 386  human
1Q47_A        318 YSMSDVRRVFl-GPYAHrdgpnyqwvpyqgrvpypr-----pgtcpsktfggfdstkdlpDDVITFARSHPAMYNPVFpi 391  house mouse
Q26473        319 FSMKSILESFd-GPFKEqetmnsnwlavpslkv-----------peprpgqcvndsrtlpDVSVNFVKSHTLMDEAVPaf 386  American gras...
Q24323        360 FHINEIQAAFn-GKFKEqsssnsawlpvlnsrv-----------peprpgtcvndtsnlpDTVLNFIRSHPLMDKAVNhe 427  fruit fly
EFZ11332      358 FNMSAVFVSFn-GPFKYqenagaawerrpva---------------hhnrqrcgspsstaPHQIMDNQRYQLMDEAVQst 421  red fire ant
O75326        337 YSLGDIDKVFrtSSLKGyhsslpnprpg----------------------kclpdqqpipTETFQVADRHPEVAQRVEpm 394  human
NP_001161655  320 YNLTDVNAVFn-GGFLAkdsakhawlpveddiv-----------pdprpgtcvddstshsYNDLLFFKSHTLMSDTLNps 387  Saccoglossus ...
XP_003378654  320 YSLESLESVFr-GPFLSkhvq-----------------------------------ppylWRDIPNPQPNYMCEQRLTdf 363  Trichinella s...
3OKY_B        315 YDMLDIANVFt-GRFKEqkspdstwtpvpdervpkpr---pgccagssslekyatsnefpDDTLNFIKTHPLMDEAVPsi 390  house mouse
Feature 1                                                                                         
3OKW_A        391 --inRPWFLRTmv------------rYRLTKIAVDnaag--pyqnHTVVFLGSEKGIILKFLarigssg-flngslFLEE 453  house mouse
3OL2_A        387 --dnRPRLIKKd--------------VNYTQIVVDrtqal-dgtvYDVMFVSTDRGALHKAIsleh-------avhIIEE 442  human
1Q47_A        392 --nnRPIMIKTdv------------nYQFTQIVVDrvda--edgqYDVMFIGTDVGTVLKVVsvpketw-hdleevLLEE 454  house mouse
Q26473        387 --ftRPILIRIsl------------qYRFTKIAVDqqvrtpdgkaYDVLFIGTDDGKVIKALnsasfdssdtvdsvVIEE 452  American gras...
Q24323        428 --hnNPVYYKRd--------------LVFTKLVVDkiridilnqeYIVYYVGTNLGRIYKIVqyyrng---eslskLLDI 488  fruit fly
EFZ11332      422 --mlEPLHTATl--------------ERFIHIAVDvtptk-lhrsVTVLYVSTATGLIKKISvlprt-----qetcIVEI 479  red fire ant
O75326        395 gplkTPLFHSK---------------YHYQKVAVHrmqas-hgetFHVLYLTTDRGTIHKVVepgeqe--hsfafnIMEI 456  human
NP_001161655  388 --sgYPLFTVTrq------------dYTLTQIVVDrvqt--gsgtYDVMFIGTDHGQVLKVVlfveng---qqksnLIDV 448  Saccoglossus ...
XP_003378654  364 --leMPKLMYNvilpisstlleqssnESYTHLSVDtvrvk-ndllVTVLFVLEVGGILKKFVhmndq----lclieVVEL 436  Trichinella s...
3OKY_B        391 --inRPWFLRTmv------------rYRLTKIAVDnaag--pyqnHTVVFLGSEKGIILKFLarigssg-flngslFLEE 453  house mouse
Feature 1                                                                         
3OKW_A        454 MNVYnpekcsydgvedKRIMGMQLDRas---gsLYVAFs----------------tCVIKVPLG 498  house mouse
3OL2_A        443 TQLFqd---------fEPVQTLLLSSkkg-nrfVYAGSn----------------sGVVQAPLA 480  human
1Q47_A        455 MTVFre---------pTTISAMELSTkq---qqLYIGSt----------------aGVAQLPLH 490  house mouse
Q26473        453 LQVLpp---------gVPVKNLYVVRmdgddskLVVVSd----------------dEILAIKLH 491  American grasshopper
Q24323        489 FEVAp----------nEAIQVMEISQtr---ksLYIGTd----------------hRIKQIDLA 523  fruit fly
EFZ11332      480 WGSLp-----------SPPMTLQFLKdt---qsLYVGMe----------------iGLLRIPAV 513  red fire ant
O75326        457 QPFRr----------aAAIQTMSLDAer---rkLYVSSq----------------wEVSQVPLD 491  human
NP_001161655  449 MYVGdps-------dsNPIVSLQLIVlgd-tksILVGTptslvnldiqqcknlsscACLQDPYC 504  Saccoglossus kowalevskii
XP_003378654  437 TPPGk----------pLLVNEMKLGM-------LYLSMe----------------eRLMRVPVQ 467  Trichinella spiralis
3OKY_B        454 MNVYnpekcsydgvedKRIMGMQLDRas---gsLYVAFs----------------tCVIKVPLG 498  house mouse

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap