Conserved Protein Domain Family
CYP56-like

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cd11070: CYP56-like 
cytochrome P450 family 56-like fungal cytochrome P450s
This group includes Saccharomyces cerevisiae cytochrome P450 56, also called cytochrome P450-DIT2, and similar fungal proteins. CYP56 is involved in spore wall maturation and is thought to catalyze the oxidation of tyrosine residues in the formation of LL-dityrosine-containing precursors of the spore wall. The CYP56-like subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410693
Aligned: 36 rows
Threshold Bit Score: 321.586
Created: 26-Jan-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
heme bindingputative
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                              # 
P21595                65 KYGAVKFFf-GSRWNILVSr-----SEYLAQIFKdedtfaksgnqkkipys----------alaaytgdnvisaygavWR 128  Saccha...
EAA63173              92 ELGDVFLC--VSPEGIICYsa---dATMGWDVMNrrntftkprdkykvl---------------epygmnvataegktYQ 151  Asperg...
EAU30487              93 LYGPVYTI--VTPWSVTCHvs---eANVVTQVCMarrsfpkpvknyegf---------------aiygpsvltsegnqWA 152  Asperg...
EDU43187              90 QLGSDNIMlsSPNGNMLWSs----dPETINQIANqaknfrkpveyfsff---------------dtygpnmqtslgdnWK 150  Pyreno...
EAL84749              91 KLGKMYMV--VTAENIVCHia---dASLVTQICNar----------------------------------------qsFP 125  Asperg...
BAE56143              90 RYGGVYMLitPSVSTCMVCd-----ASVASQICMsrhgfpkpikqygalemygpnivtvrcpnvfrvsanvsqsegsqWA 164  Asperg...
EEY14369             102 KHGETFAL--VSPFQILIItd---sAEVIHQVSQqrdkfhklleiydil---------------rqygdnllstegaaWR 161  Vertic...
EDU43186              94 DLGTDSFFlcSPSGPMLMTc----dVHLVKQVLMrahdfhapvevlgly---------------niygptlaasegeqWR 154  Pyreno...
WGS:AACS:CC1G_10879   79 VYPLISILspAQNYTVQIAd-----VNAAKEVTTyrsrfpkpmefyrhl---------------tfygknivaaegddWK 138  Coprin...
WGS:AACS:CC1G_05620   99 LSGPSFYA--VGSWEVATQllslpkPKEYNIVFSiwgdnmf-------------------------------tvsgddWK 145  Coprin...
Feature 1                  #      #                                                      #               
P21595               129 NYRNAVTNGLQHf------dDAPIFKNAKILCTLIKnrllegq-----tsipmgPLSQRMALDNISQVALGfdfgalthe 197  Saccha...
EAA63173             152 FHVRITAPPFGDlsgvnnlvWRETVHQTKRLTEAWAespp----------teiqKDVNALTLAIISLAGFGkrlewskng 221  Asperg...
EAU30487             153 RYRRYTSATFNEknn--alvWQESIRQGIQMTNYWEekhasdsphtlfslpdvrDDIVKFTLNIICSAGFGvtlpfkpay 230  Asperg...
EDU43187             151 AQRKMVAPAIGShsn--aamWQSSLLQAERLTALMTadgpv--------ishmkDHMSEISLHCIAQCFFNknley---- 216  Pyreno...
EAL84749             126 KPIWQYAPTFNEkns--alvWEESIRQMTEMLHHWQvagtseklh-gfvvastrGDLLKFSLNVLCGAGFGvklpfkqlp 202  Asperg...
BAE56143             165 HLRRHTATPFNErns--alvWEETIRQTKEMVQYWEdeysrsssasefiltdtrEDILKFTLNIICSVGYGvklpfrpgl 242  Asperg...
EEY14369             162 RHRKATSPAFTEknv--aliFQEAVAQSQSMIRYWTvnedgtpr--tgtiesvdRDTCRFALGVIGFVGFGlril----- 232  Vertic...
EDU43186             155 LYRRITTPFFNQkty--gkvWKDSLEKTERLSAQWShgnddaq-----iadvkeQLMSKLNLRIIAKIFYDqelrydaen 227  Pyreno...
WGS:AACS:CC1G_10879  139 KYRKVCAPAFNDrnn--klvWEAAIRIMDDLFRDVWehkdev------evphivDTTVLIALFVIGEAGFGek------- 203  Coprin...
WGS:AACS:CC1G_05620  146 RHRRVVAPAFNNs------lYSLVVEETTALYREILheekwedas-svvapdfrRITRDLAFLIIAKCGFGfdmtwkgfk 218  Coprin...
Feature 1                                                                                                
P21595               198 k----------------nafhehlirIKKQIFHPFFLTFPFLDVlp---------------------------------- 227  Saccha...
EAA63173             222 ek--------------egvpagyqlsFLHALQDTLHYMVPILLFprwvl-----------------------------rv 258  Asperg...
EAU30487             231 k----------------attgdaeglFQDAVMPPQGYSFTFPSVmeyistsmstvffang--------iwpkwiprrmap 286  Asperg...
EDU43187             217 ---------------------etikeFPSRELPEGRFGFVEAMF------------------------------------ 239  Pyreno...
EAL84749             203 q----------------estndpndvFKDTEKPPEGFSFTFRSAvaymnlrimtvvlatm--------vipkwipralmp 258  Asperg...
BAE56143             243 e----------------nstesaeglFKDAITPLPGYHFTFRSAmeylnkhitsmfiang--------llpkgiprsvlp 298  Asperg...
EEY14369             233 ----------------------wpgqASPEHADPKWHKFESLEVpegyttsfseclvgnmsnimwlmlappwvlrrlpfe 290  Vertic...
EDU43186             228 amkd----------vapvghvltfseAINAVLSNLATVFSIPKWllar-------------------------------s 266  Pyreno...
WGS:AACS:CC1G_10879  204 ------------------------ltWKNDVVAPPGFKYTVKEAlhvvsrhliykvi-------------lpnwayklsk 246  Coprin...
WGS:AACS:CC1G_05620  219 pggegagdgcmdvqqalyyatdiwnvIKRMFVPKWAYYLPIPSLrkldntwkaldaylhqta----asrsekvvddpeaa 294  Coprin...
Feature 1                                                                                                
P21595               228 -ipSRKKAFKDVVSFRELLVkrvqdelvnnykfeqt-----------------------------tfaasdlirahnnei 277  Saccha...
EAA63173             259 ilhKAALAHAQLDRYLREIIrdqkaklsadinhsdkqsrgnlltav--------vrasmvfdseqsskessrssgerkqg 330  Asperg...
EAU30487             287 ffkTDFMAYDDLGKYLRALLdnaevrenpsshnllegl------------------------vrarrenselgsthrvdg 342  Asperg...
EDU43187             240 ---TTIDKLGIIDSIPKSLRdtliastrp------------------------------------------esaerngkv 274  Pyreno...
EAL84749             259 wlkSDFEAHRDLEAYLRKLIsmgkaektadkpdnsqnlvq---------------------gllmsrnkeaasgsskgig 317  Asperg...
BAE56143             299 ffkKDFDAFDDIGRYLRALVstaetketlsqnlidgl---------------------------vrskqkidkdqgldpe 351  Asperg...
EEY14369             291 ctkRAADAREDFDKYIDEMIrnktedviklnngdpgmdllghlvrtkyaregptrvtssdtekqsggaapgqlrlapepl 370  Vertic...
EDU43186             267 pfeSHKKAYQGFVEWQQYMLemrnsvqsrldsakqkeepy--------------------fleslvissdaassrdgirp 326  Pyreno...
WGS:AACS:CC1G_10879  247 slaDIDLAFKEMGMYMQEMIrerstgekssgrhdlmt---------------------------alvennvtlpaddpnr 299  Coprin...
WGS:AACS:CC1G_05620  295 sdfSRSSSSDVFTRLVKSVVglg------------------------------------------------------kls 320  Coprin...
Feature 1                           ##  ##  ##  #                                                        
P21595               278 IDYKQLTDNIVIILVAGHENPQLLFNSSLYLLAKYSneWQEKLRKevngitdp------------kgladlplLNAFLFE 345  Saccha...
EAA63173             331 FTEDETMGNLFIYLLAGYETTANAIIYGLAVLALHQd-IQDQVIEeidraharaqsanrseltyeddfefleyTYGFMYE 409  Asperg...
EAU30487             343 LSDEEIFGNLYIFMIAGHETTATTLRFALVLLAMHQd-VQDHLYDeiqevtmgepanpt-gwdyertfpklvaPLCIMLE 420  Asperg...
EDU43187             275 LDRETLTGNVFFFLLSGHGTAGNTLGFMMFLLAIRQd-IQADLHAhldaelggkpidtw-svtdefmrlyngyTGAVLKE 352  Pyreno...
EAL84749             318 LTDLEIIGNMHIFTIAGHETTATSLRFTLLLLALHQd-VQDWLYEgvleaahgepkdva-qwdyhrmfpklitPLCVMLE 395  Asperg...
BAE56143             352 LTEDEILGNLFVFTIAGHETTAVSLRFALVLLALNQd-AQEYLYEgireatydeprnpv-ewdyrrvypklvsPLCVMLE 429  Asperg...
EEY14369             371 LSDSEIIGNAFIMFIAGHETTANATHFTAVHLAARPa-SQRAVQRdidhifdrdsnpaswkyedcinpmsasmIGASLNE 449  Vertic...
EDU43186             327 LTEAEVLGNMFFYVMAGFDTTSTTLSFVFLLLAIYPs-AQTLLQQdldrvlgsratsaw-dankdvpellngyLGAVISE 404  Pyreno...
WGS:AACS:CC1G_10879  300 LTDQELMGNVFIFMLAGHETAAHTLGFAFAFLALYPe-EQKKLYDhiksvipeght------ptyedmpkltrCLAFINE 372  Coprin...
WGS:AACS:CC1G_05620  321 LSEQELIGNVFMLMNAGHDTTGMTLCETVALLALHQe-EQQKVYEeicavlgdqep-------teallkqlsyTWACVLE 392  Coprin...
Feature 1                 #         # #                               #                                  
P21595               346 VVRMYPPlsTIINRCTTKtck--------lgaEIVIPKGVYVGYNNFGTSHdp-------------ktWGTTADDFKPER 404  Saccha...
EAA63173             410 TFRLFPGv-TLITKMIHQperiitdgpdgspkSYDLPAGTRVYLNAPVVHYhp--------------kYWPEPYKLDPNR 474  Asperg...
EAU30487             421 TLRLYPPv-SSLPKWTDTssasi----syrdqAYQIPPATYLCLDANALHYde-------------myWGPNASEFDPSR 482  Asperg...
EDU43187             353 AMRLYNVv-EFIPRRCTAeasvt----dlngnHFTIPRDTLCLLNFTAAFRhpsiwpagptandpatgKYHPMLDFDPSR 427  Pyreno...
EAL84749             396 VLRLYPPv-VTVPKSTSEtpspl----tyqgkQYVLPPRVNINLNTNCLHYse-------------qyWGPDVAIFYPQR 457  Asperg...
BAE56143             430 TLRMYPPv-SGIPRWTGDsavni----tyhnqPYLLPPHVYVNVNASGLHYse-------------eyWGPDAAVFLAKN 491  Asperg...
EEY14369             450 TLRLIPAa-GELPKRVNPerdgiv---tihgqRHALPGNAHILVVSLAAHRnpnlwpt---qpsritaKENDLDDYIPER 522  Vertic...
EDU43186             405 TLRLYHPv-AWYARKTVRdttvt----tasgaICRIPKETIIIIDVAAIGRhpgywspstspgddtsiEQSPARDFDPVR 479  Pyreno...
WGS:AACS:CC1G_10879  373 TLRHFPPi-IELPKKAQEdtvlhttnhygekvSVPIPKGGCISVNIPATHHnp--------------kYWDDCDSFNPDR 437  Coprin...
WGS:AACS:CC1G_05620  393 ATRMYSPa-SSLTRILPEdkvvkv--qrpspkEIVLKKGTLVIIDTVSIHLnp--------------hTFPDPLKYKPSR 455  Coprin...
Feature 1                                                              ###   #####  ##                   
P21595               405 WGsdietirkn------------------------wrmaknrcaVTGFHGGRRACLGEKLALTEMRISLAEMLKQFr--- 457  Saccha...
EAA63173             475 WRssqgekhvva----------------------sdrtrqmkgtLLTFSDGSRACLGRKFAQAEYVAFFATLLRQYrvr- 531  Asperg...
EAU30487             483 WDkrnidsflakndgldgl--------sgpglehdtihrpvrgaFLPFSDGLRACVGKKFAQVEFVAALVIIFRNY---- 550  Asperg...
EDU43187             428 WDsfadkitk--------------------------psevglrtYFPFGLGGRACLGKSLGSIMMVGVLAYIFTHFs--- 478  Pyreno...
EAL84749             458 WDarnqnsflaknastqgl--------agpglefptvhkpvrgaFIPFSDGFRACLGKKFAQVEFIAALSALSRNYkve- 528  Asperg...
BAE56143             492 KEgglsgpgley----------------------dtihkpvrgsYIPFSDGFRSCIGKKFAQVEFVVAMAIIFREYrvm- 548  Asperg...
EEY14369             523 WFrtgdgsvqsggtegqqaniaedndsfrftdtseklfrpapgaYTPFGDGPRSCIGRRIAQAEVMVAISVLFQKYsv-- 600  Vertic...
EDU43186             480 WLnptd-----------------------------------naaAFPFSAGHRMCPGKRFAEVEMCAILARVFSQFsl-- 522  Pyreno...
WGS:AACS:CC1G_10879  438 FLgewp-----------------------------------reaFLSYSAGPRSCLGRKFFETEAIAVLTSTLLQYev-- 480  Coprin...
WGS:AACS:CC1G_05620  456 WIgvp------------------------------------esqVTVFGTGPRACIGRKFAQLESLAFLALLLREWrvdl 499  Coprin...
Feature 1                                                           
P21595               458 ----wSLDPEWEEKLtpa-------------gpLCPLNLKLKF 483  Saccharomyces cerevisiae S288C
EAA63173             532 --lapGSDPAVVERDlfgksag-----titlapLANVRLHIQP 567  Aspergillus nidulans FGSC A4
EAU30487             551 -----RVTLQKHADEs-----------------ESEMRCRVQQ 571  Aspergillus terreus NIH2624
EDU43187             479 ----iELVPSHAVEEeatrtgade-kwvkertqEQALQMLVDE 516  Pyrenophora tritici-repentis Pt-1C-BFP
EAL84749             529 ---laDDSPEGRNDAervl-----------resTSVLTLSMRE 557  Aspergillus fumigatus Af293
BAE56143             549 --lakSNERETEDDLrrraek-------algesTAFITLSMRD 582  Aspergillus oryzae RIB40
EEY14369             601 ---elAVDEWATDEEvermdr------aarrmlYAKAQVRFRE 634  Verticillium albo-atrum VaMs.102
EDU43186             523 ---rlEADPADVLKAegpt-----------ghgTPQLEELSRE 551  Pyrenophora tritici-repentis Pt-1C-BFP
WGS:AACS:CC1G_10879  481 ---flKEEPQFAHETfeqr-----------karILNVKCEVAD 509  Coprinopsis cinerea okayama7#130
WGS:AACS:CC1G_05620  500 alnldSEGPEETREEyvervfgkaglngfvfgiKSRIPIRLTR 542  Coprinopsis cinerea okayama7#130

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