Conserved Protein Domain Family
CYP_FUM15-like

?
cd11069: CYP_FUM15-like 
Fusarium verticillioides cytochrome P450 monooxygenase FUM15, and similar cytochrome P450s
Fusarium verticillioides cytochrome P450 monooxygenase FUM15, is also called fumonisin biosynthesis cluster protein 15. The FUM15 gene is part of the gene cluster that mediates the biosynthesis of fumonisins B1, B2, B3, and B4, which are carcinogenic mycotoxins. This FUM15-like subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
?
PSSM-Id: 410692
Aligned: 44 rows
Threshold Bit Score: 411.663
Created: 25-Jan-2010
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
 
heme bindingputative
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                      #   #      #   
W7LC91    106 PVDLARYRsf---lGFERLLIIs-PKALAEVLttksydfrkpglivse-lkqatgmgvllaegseHKSQRKALQTAFnyr 180 Fusarium verticill...
EDR15715   70 YGKVVKFSga---lWHPVVSITd-FKAISFILgegiyslpkprgvrawfratlgegilwvegklaHEHQRRILAPALnqq 145 Laccaria bicolor S...
EDR16193   18 YGHVARLRggmfglQADGLYVTd-PAALNAILvrnqnnfresvefsglfgvihhgdglasvygaeHKKQRRLMNPVFtas 96  Laccaria bicolor S...
AAW43969   93 YGPTVRYRva---lGAQRFLTId-PTALNYILshadlfpkpsrvrkal--sdllgnglltaeghtHKKQRKALNPSFspa 166 Cryptococcus neofo...
EDR10845   70 YGTTFRYKsl---lGISRLYTAd-TRALNHILmnsydyeklpesraal--tnilgagllvvegdkHKQQRKIMNPAFgpa 143 Laccaria bicolor S...
EDP44577   15 LDHVLRKRa----yAFPKIRLA--QRLIGGVMgngllv----------------------aegevHRRQRRAIQPGFhsr 66  Malassezia globosa...
EED83115   72 CGPIFKIKaa--lfHPDIVVVTd-HAAVQHIFqnvddyvkspafrppv--anvlgkglvwaegddHKNQRRILATAFspe 146 Postia placenta Ma...
EDR15545   88 YGGVLKINal---fGADRPSYE--TNAYHLLRsrlsfgyg-----------------lvgttgakHLKQRRLMAPYFask 145 Laccaria bicolor S...
EDP41615   89 LGQVYRYRhm---fYVQRVLLAd-PKALIHVLspakayqypkpeytssflaavlgdglvsiegekHARQRKIIAPAFaps 164 Malassezia globosa...
AAY20974   70 YGSTLRFAg----iAGAPVLNStdPKVFNHVMkeaydypkpgmaarvl--riatgdgvvtaegeaHKRHRRIMIPSLsaq 143 Xanthophyllomyces ...
Feature 1                                                                                #    
W7LC91    181 hiknlyPVFWDVAGEFATVLEKQIPTGTprtsdtt------------------------avidivdWASRATLDIIGRAG 236 Fusarium verticill...
EDR15715  146 avrgltPVFFETSAKLAMQWTKLFDASSvdeme----------------------------iditnWAGRFALDTIGRAA 197 Laccaria bicolor S...
EDR16193   97 fvsklsPVFYKIAHQLRDKLKADVGNAKdgrvi-----------------------------dildYLTRTALELISQGG 147 Laccaria bicolor S...
AAW43969  167 avrgmiPVFYDKAYELKAKLLGIIEGDEteqasptpckeed-------------eveggkkidvmkYLGKTTLDVIGIVG 233 Cryptococcus neofo...
EDR10845  144 qireltDIFVRKSIQLRDLWAEECTKQGgqgri-----------------------------eilsWLTWTTLDVIGLAG 194 Laccaria bicolor S...
EDP44577   67 aikrlaPVFQQHAFNLLAYLRTQTREHDsqli------------------------------dvytPLSAAALDALGDGA 116 Malassezia globosa...
EED83115  147 avkgmsDDIAECSEKLESRLTNHVLSHGggsti-----------------------------niveHTSTCTLDIIGRVA 197 Postia placenta Ma...
EDR15545  146 ylrtllPVFYPFAYELCDDIEKKIKKYDgvin-------------------------------mhrMMSIAALEYVGTGL 194 Laccaria bicolor S...
EDP41615  165 vvkdyqPTIHRHAKLLVEKLRLIVQQEIdrhsgkipadthitgqsesdrsvvlknpgseavidvlfWLSRTTLDIIGEIG 244 Malassezia globosa...
AAY20974  144 avksmvPIFLEKGMELVDKMMEDAAEKDmavgesagekka--------------trletegvdvkdWVGRATLDVMALAG 209 Xanthophyllomyces ...
Feature 1                                                                                     
W7LC91    237 mgQGFDAIQNDd----------sRLHQAYRMIFEPSrgaiflallrlifp-----------erlvnwlplrrnkRMRHGI 295 Fusarium verticill...
EDR15715  198 fsYDFDCLSGAp----------hPLEEALNGLTNCEhksssfymralfw------------lfppvlsmgkkgeMIQKTK 255 Laccaria bicolor S...
EDR16193  148 lgHSFNSFDKNsre-------ftEFHEALKTVLPMAgriffvlpyleswrkleplwlrrflsnavyylpwpaarKFKWGV 220 Laccaria bicolor S...
AAW43969  234 fsYDFKALSEPr----------nELSEAYSKMFQAGmdanfwdflrgai-------------plvnklpnkratEIAARK 290 Cryptococcus neofo...
EDR10845  195 fnYKFNALMRDsk--------anELSEAFNTIFQAGtsvnvmlilrafi------------palswilpeagdvEAKKAS 254 Laccaria bicolor S...
EDP44577  117 lgASFGALASLivhpsgivhaahPLTAALDRTLRIAshpskyallmdtatl--------yfpilehipiglsshAFRREA 188 Malassezia globosa...
EED83115  198 fgYDFKAGQSTea---------qQIRASWEGHVNSGiqfgafiamlvi---------------racpsvfllplPAIKAG 253 Postia placenta Ma...
EDR15545  195 g-YRFDGLNESkp---------nEYNDAAKALNPLTfklstyraflpywvqlgp---awfrkrlvdwvpwpdlhRVKAVI 261 Laccaria bicolor S...
EDP41615  245 fdADFRSLERGnr---------dPLANSMATLMEAVlnidlglaiflilsek-------pglqwlrkiptkrttTIRDAK 308 Malassezia globosa...
AAY20974  210 fdYKSDSLQNKt----------nELYVAFVGLTDGFaptldsfkaimwdf-----------vpyfrtmkrrheiPLTQGL 268 Xanthophyllomyces ...
Feature 1                                                                                     
W7LC91    296 QVIRSKCQELIRERKEKIkrqka---------gvdnSGNDILTVALLNGvf-------------------tDEQLIDQLM 347 Fusarium verticill...
EDR15715  256 YELGVIASRMWWDAKVAGd----------------rDSKTVMAHMLRRDdsfph-------------slldEQHVVSQMR 306 Laccaria bicolor S...
EDR16193  221 DTMHPVCANLFKQKKKVLdeggise-----lekttsGGKDLATLLISANqladd------------ddrmpDEVVIANMS 283 Laccaria bicolor S...
AAW43969  291 AVTLRISKKIVEDKKREVmsahseg-----lekredIGDDLLSILIKANmasdvk----------peqklsDEEVLDQIT 355 Cryptococcus neofo...
EDR10845  255 STMSRIGKELLSNSKAAVsqqesl-------ekdtwKTRDLLSLLVRANvatdlt----------esqrmlDEDVLAQIP 317 Laccaria bicolor S...
EDP44577  189 RVLFDLAGSIVDDAQARIrce------------thdTSPDILASLLRANanakrarsgekkhsvldhailtDAELHAQVS 256 Malassezia globosa...
EED83115  254 GRIREIVSKLSMRLLRRGaf--------------ndRGRDILSILMKNDgaraak-----------eerltPQQIVDNIS 308 Postia placenta Ma...
EDR15545  262 YRMDDIAQDILQTRKQAFadg-------------esYGRDILSAIMRYNdeaed------------dekidKDEIISHIT 316 Laccaria bicolor S...
EDP41615  309 KTVEKHAEEIVERMRNEIlsesqglskenfddgsatRSKSLISRMIRANmasdlk----------psermsNAELMGQMT 378 Malassezia globosa...
AAY20974  269 AVSRRVGIELMEQKKQAVlgsasdq----avdkkdvQGRDILSLLVRANiaanlp----------esqklsDEEVLAQIS 334 Xanthophyllomyces ...
Feature 1     ##  ##  ##  #                                                                  #
W7LC91    348 TFLAAGHETTATALTWAIYILCKQP-EVQNRLREEIRmhfpnpkgwprser----pssntlqqaidfkLPYLNVVCLEVM 422 Fusarium verticill...
EDR15715  307 TIISAGYETVSAVVAWILYELASDN-QLQVALREEFSslldhsm------------------dsvnsrCPLLDAVLKETL 367 Laccaria bicolor S...
EDR16193  284 SIVLGGQETTSGALSRLLCLMANDN-DMQNRLRKELLdahaakgde-------------gfnynelneLPLLDAVCREAL 349 Laccaria bicolor S...
AAW43969  356 TFMLAGNETSSTALTWILYSLTQHP-ECQTRLREEVLavpddrp-----------------sletlnnLPYMDAVIREAL 417 Cryptococcus neofo...
EDR10845  318 TFIVAGHETTSNATTWALFALNSQNpDAQIKLRNELLtvstdnp-----------------tmdelnaLPYLDAVVRETL 380 Laccaria bicolor S...
EDP44577  257 TFIFAGHETTATQMAWLLLFLAKDQ-RRQQTLREAIGakraalglmpharaepteaceralsaeeledIPYLDWCVRECL 335 Malassezia globosa...
EED83115  309 TFMMVGHETTAGSLNFTLLELARRP-GLQRRLREEVRrkgrelt------------------yedvqrLELLDAVVKEGL 369 Postia placenta Ma...
EDR15545  317 TTLFAGHETTAGVLSRIIHQLSLHH-DAQERLREEVTkareakgd---------------lefedlleLPYLDAICKETL 380 Laccaria bicolor S...
EDP41615  379 TLIIAGHETTATQNSWALWLLAMHP-EAQDRLRKELQeavakeraemdnlseeeraiydtqpvrdinsLPYLDNVVKESV 457 Malassezia globosa...
AAY20974  335 NLLFAGYETSSTVLTWMFHRLSEDK-AVQDKLREEICqidtdmp-----------------tldelnaLPYLEAFVKESL 396 Xanthophyllomyces ...
Feature 1             # #                                               #                     
W7LC91    423 RYFAPiPLTMREATCDtt---------------iLHTFV----------PAGTRIILAPRVTNRdsaLWGPDANNFNPDR 477 Fusarium verticill...
EDR15715  368 RLHPAiLENHHETAHDic--------------lpLSEPIpgmnelqlflPKGTLLVIPVNAIQSdpeIWGPDAKIFRPQR 433 Laccaria bicolor S...
EDR16193  350 RLFAPvTFVWRQTIEDcvvplhfpirdpktgvetKELLI----------TKGTSVYVGLGAANRsaaIWGPDASELKPER 419 Laccaria bicolor S...
AAW43969  418 RLHAPaPGTMREAKEDtviplsmpv-igrdgkqiDSVKI----------NKGTMVFIPIITVNTspaIWGPDARVFNPDR 486 Cryptococcus neofo...
EDR10845  381 RLHAPvSMTSRVAMKDdvlplaipf-tdskgvihHEIRI----------RKGEPLLIPILALNRdksIWGEDAHEFRPER 449 Laccaria bicolor S...
EDP44577  336 RLQAAiHTTSRVATDTdwip----------lssgRSIQV----------HRGMIVLIPLTSIMTsehHWGADPEEFRPER 395 Malassezia globosa...
EED83115  370 RLYPAsPQTERVALKDdviplnkpv-ctsdgtsiTSLRV----------AAGQVFHIPFTTMHVnpaVWGPDAAEFKPER 438 Postia placenta Ma...
EDR15545  381 RVYPPvDQLYRTSVKPtvipilypi-qstdgkelREIAI----------EPGTDTIVSIVGYNRnksVWGADAEEWIPER 449 Laccaria bicolor S...
EDP41615  458 RMLPSiPSTVRVALKDdvvplsrgykradgkgtyNSIMI----------PKGHELFIPLNVIQLskeLWGEDAQDFNPSR 527 Malassezia globosa...
AAY20974  397 RLDPPsPYANRECLKDedfiplaepvigrdgsviNEVRI----------TKGTMVMLPLFNINRskfIYGEDAEEFRPER 466 Xanthophyllomyces ...
Feature 1                                                       ###   #####  ##               
W7LC91    478 WLSpkngnreateqskfkignqkrdstaapevtqeevrgrtearsnyadLTFLHGPRSCIGQSFARVEFAILLATLIANF 557 Fusarium verticill...
EDR15715  434 WLEmkqngn----------------------------------rrgrelLAFSEGPRSCIGKSFAIAEIKALVVTLVRQF 479 Laccaria bicolor S...
EDR16193  420 WLGkavldgtans--------------------------vkmpgifsnaMTFLGGGRACPGMKFALLEIKLVLSVILPHF 473 Laccaria bicolor S...
AAW43969  487 HLKtssdsfggan--------------------------mhvpgvwgnmLSFLGGARNCIGYKLALAEISTILFVLIRSF 540 Cryptococcus neofo...
EDR10845  450 WESipdaassi-------------------------------pgvwghmLTFLGGPHSCIGYRFALVEMKALLFTLIRSF 498 Laccaria bicolor S...
EDP44577  396 WAEptlkgpr--------------------------------afpahngLSFLMGPRACIGSAFALLEMKVFIATVLSEL 443 Malassezia globosa...
EED83115  439 WFVpggvpppse-----------------------------lphgwsglVTFCDGPRNCIGYRLAIYEFKVILATLVRSL 489 Postia placenta Ma...
EDR15545  450 WLEplrtsvlqa----------------------------klpavfshmMTFTLGERACIGYKFAEMEMKLILSVLLSRF 501 Laccaria bicolor S...
EDP41615  528 WDNlpssvina-------------------------------kmppghlFAFLSGPRSCVGKQTAILETQVILAHMILNF 576 Malassezia globosa...
AAY20974  467 WLEdvtdslns------------------------------ieapyghqASFISGPRACFGWRFAVAEMKAFLFVTLRRV 516 Xanthophyllomyces ...
Feature 1                                   
W7LC91    558 EfqiedesLLDERNISISRGat-sRIVGGL 586 Fusarium verticillioides 7600
EDR15715  480 S-------FTCPYEIEAFQS----FVVRPR 498 Laccaria bicolor S238N-H82
EDR16193  474 Sfea--vtEEIEWRLGITVVpy-vKGKVGE 500 Laccaria bicolor S238N-H82
AAW43969  541 EfqelkskPEVEKKASVVMRp---RIKGEE 567 Cryptococcus neoformans var. neoformans JEC21
EDR10845  499 EfelavpaSDIGKKAGIVHRpillSNPEGG 528 Laccaria bicolor S238N-H82
EDP44577  444 Yfew--dgRPIVPKLWVVAR----PFDASC 467 Malassezia globosa CBS 7966
EED83115  490 Efr----eTTAEVHTRISPTl--qPVTDGQ 513 Postia placenta Mad-698-R
EDR15545  502 Rfsi-dpkNEIFWNMGGSIT----PIVKDS 526 Laccaria bicolor S238N-H82
EDP41615  577 Rfdv--vpGWDLVQRQQIVRr---AFVEGQ 601 Malassezia globosa CBS 7966
AAY20974  517 Qfep-iisHPEYEHITLIISr--pRIVGRE 543 Xanthophyllomyces dendrorhous

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap