Conserved Protein Domain Family
CYP52

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cd11063: CYP52 
cytochrome P450 family 52
Cytochrome P450 52 (CYP52), also called P450ALK, monooxygenases catalyze the first hydroxylation step in the assimilation of alkanes and fatty acids by filamentous fungi. The number of CYP52 proteins depend on the fungal species: for example, Candida tropicalis has seven, Candida maltose has eight, and Yarrowia lipolytica has twelve. The CYP52 family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410686
Aligned: 57 rows
Threshold Bit Score: 441.996
Created: 3-Apr-2007
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
heme bindingputative
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                           #   #      #        
P30611               88 HVHTFVTKVLg-NELIMTkDPENIKVLLRFPVFDKFDYgtrssavqpSLGMGIFTLEGENWKATRSVLRNMFDRksi-dk 165 Candida ...
AAL67906            101 LGQTFEVYILw-DSNYVTsDANVIKTILATDFDNFVKGekldvcvrpVLGTGVFNSDGEMWKFHRSMTRPFFTReri-sh 178 Phaneroc...
EAL85431            116 PFQTLEVRLGp-QTVIVSrDPQVVKALLTTQFGDFGKGerfhtewreFLGDAIFTTDGDKWHASRALIRPMFTPdrv-sn 193 Aspergil...
EAA59226            108 DKKTVELDAGisSRIIFTrDPENIKAILTGQFSDYGKGesfhrdwreFLGDSIFVTDGEQWSASRHLIRPMFVRdrl-vd 186 Aspergil...
EAA60936            403 SPNCVESNIFgsFRVIQTrEPEHLKAVLTGKFADFGKGelfhklwipFLGDSIFTTDGKEWQGSRNLIRPMFIKdri-sd 481 Aspergil...
EAL22122            109 YGGTYNTRVLg-EDQIISsDPKVIKHVLIDDFDNFVKGqkfkeraqdFLGDGIFNSDGDNWKFHRSFMRPFFQPky--is 185 Cryptoco...
EAA28794             87 GGYTGEVRLVg-HRIIFTsEPENMKAILATQFEDYGKGegfhqewkdFLGDSIFTTDGDLWHASRQLIRPQFIKnrv-sd 164 Neurospo...
EEQ39970             80 GADTLDFTGFg-SKIFFTkNPHNVKSLFATNFDDWSIGarkr-afkpFLGVGVFVTDGEVWKHSRTMLKPQFSReqi-ah 156 Clavispo...
EAL86290             80 YGDTYASRILt-QRVYFTcDPRNIRHVLINRFSDFDASdvrahlfapITPHGIFAVDGAEWKEARSLYADIFSAtrkifd 158 Aspergil...
WGS:AACS:CC1G_05498 118 YGHTFELRLPs-ENQIWTtEPEHVKAMLATQFQNFEKGhgfiqqmhsFLGTGVFNSDGDMWKFHRAITRPFFTRdri-sd 195 Coprinop...
Feature 1                                                                      #                        
P30611              166 VHDFEPHFKTLQKRIDGKVGYFDiqq----------------efLKLGLELSIEFIFGQVVSedv--------------- 214 Candida ...
AAL67906            179 FDLFDRHADATMAKMKARLAEGFavdf-------------qdliSRFTLDSATEFLFGQCTTga---------------- 229 Phaneroc...
EAL85431            194 LSTFERHVQKLLRILESPRHERQpvnv-------------ldlcLRLTMDIATDFLLGQSVDsls--------------- 245 Aspergil...
EAA59226            187 TEIFEKHVQHLIPLLAGNNESKIvdvt--------------slfFRYTLDAATNYLLGQGTDslq--------------- 237 Aspergil...
EAA60936            482 LDIFERKTQTMLSLYSPCGEPTDvvd----------------lfYRMTLDAITEFLLGKGINsle--------------- 530 Aspergil...
EAL22122            186 PLHFSTNVQNFFAKLPSYGKVFDmqa----------------hiGQLALELAIMWLCGEDMSrdtnnvaw---------t 240 Cryptoco...
EAA28794            165 LQCFENHMQMLFRTIANGGALNGedqmvdmeagngkpvdisdlfFRYTLDAATDFLLGKDIKsls--------------- 229 Neurospo...
EEQ39970            157 VHSVESHYKLFAQHIRSYRGQEFdiq---------------plfMKLTMDASSEFLFGESIHllhddsieh------ekd 215 Clavispo...
EAL86290            159 LQLQEDGFQGLIKQIPRGQAMDLap-----------------lfLKLVLDVNSAFAMGTGLDtlkqd------------- 208 Aspergil...
WGS:AACS:CC1G_05498 196 FDIFDKHAAQTLELARARLAEGYaidf-------------qdlvARFTLDSAAQFLFGEKIDslsagipypknsrkpnpp 262 Coprinop...
Feature 1                                                                                               
P30611              215 ----phYDDFTQAWDRCQDYMMLrlllgdf--ywmandWRYKQSNQIVQAFCDYLVQKSlent---------------cn 273 Candida ...
AAL67906            230 ----srTEDFARAFAEAQDAVSFrlr----------mgWLWPDAVARADKIKRENGGRVpevkg-------------eie 282 Phaneroc...
EAL85431            246 ----npTHRFSAAFADVQRIQSWitmagpl--qvflpkAKYYEGLKTINSFVDPFITRTlalgrrsfe------emegse 313 Aspergil...
EAA59226            238 ----npETEFAEAFRYVQRRQAQyfrlgvf--kfvlsrTEFRRQLKVMDDFIKPYIDRVlamspael--------dqkls 303 Aspergil...
EAA60936            531 ----npQADFALAFADVQRIQTLltmlgpa--qylyprGRYNQGLKVINDFVWPFVHDTlgfqadd---------lkssd 595 Aspergil...
EAL22122            241 eewkkaKGEISWAMTEAQKIVGKrvkigtiwplfevrhDPLERPMKVIRAFFRPIISRAlnrkrqrc--------kldnt 312 Cryptoco...
EAA28794            230 ----tpVQPFADAFQEVQRVQIViaragpl--nrfvpkKTFWEGLKVIDETINFYIDRAlrldeeela------skskgd 297 Neurospo...
EEQ39970            216 tsdikgKKELAEDLSFLQTYLMFrvmlldw--fwlensKKFSEAIKRVHAFTSQFVDRVlsltpeer--------eansk 285 Clavispo...
EAL86290            209 --qsleKKEVAEALMYAKKIMARdgflgpl--hyllsrKDFYAACETVKAYVEKVVRKEmtareyqkqsnaatvdderqk 284 Aspergil...
WGS:AACS:CC1G_05498 263 sftshpSNIFVNAFLSGLHGVTMraiigqewplaeflrDTVKPNRDIVDQIIEPIVDKAlre------------------ 324 Coprinop...
Feature 1                                       ##  ##  ##  #                                           
P30611              274 dkFVFVHQLAKHTtNKTFIRDQALSLIMASRDTTAELMAFTILELSRKSHHLGKLREEIDANFGlespdllt--fdslrk 351 Candida ...
AAL67906            283 edETLLDHLVNVV-QTKILHDEVLNIMIAGRDTTGGTLTSAVYFLSQYPEVLRRLREEILEKVGptrrpty----ddire 357 Phaneroc...
EAL85431            314 eeYNFLEGLATFTqDPKVIRDQLISVLLAARDTTAATLARTLYELSGHPDVVQRLREEILAQVGtasapty----adlkn 389 Aspergil...
EAA59226            304 ksDTFLHALARFTrDRRTLRDQLVAILLAGRDTTAATLSFCLFELARNPEVTAKLREEIASRLGlgasaqkp-sytdlke 382 Aspergil...
EAA60936            596 ksFTFLHALANYTrSPKTIRDQVVSILLAGRDTTAATLSWAFYELSHYPEAYSKLRAEILDKVGptrapty----ddlkn 671 Aspergil...
EAL22122            313 edVYMIDRLVEATdDIKLVEDQLINVLLASRDTLASLLTFSVYAIVLHPDIAVRLKDEVFTIANqecevtk----dtirq 388 Cryptoco...
EAA28794            298 egYTFLHALAGFTkNRQVLHDQLMAVLLAGRDTTACTLSWAIYELARHPEAVAKLRAEILSVVGpdrapty----ddlks 373 Neurospo...
EEQ39970            286 dgYTFLYELAKVTnDPIVMRDQILNVMLAGRSTTASLLCSVLLELSRNPEVYEKLKNEVYEQFGngktkgeeitfetlkk 365 Clavispo...
EAL86290            285 rtQSLLSRILDNTnDVHAVRDAVVTILIAGTDSVASMLSTTFYLLARHERVYAKLRQEILDTIGteppty-----dnirk 359 Aspergil...
WGS:AACS:CC1G_05498 325 asTLGDVEKVEKGeEETLLKHLLLNLLVAGRDTTACTLTYSVYMLAENPHVAERLRSEILNKVGekgrpsy----ddird 400 Coprinop...
Feature 1                          #        # #                               #                         
P30611              352 fKYVQAILNETLRMYPGvPRNMKTAKCTTTLPKGggpdgqdpiLVKKGQSVGFISIATHLDpvl-------nfGSDAHVF 424 Candida ...
AAL67906            358 mKYLRAFINETLRLYPAvPWNVRYPVKDTTIPGPhpd---kpyFIPANTPVSYSVHCMHRRtd--------ywGPDAEAF 426 Phaneroc...
EAL85431            390 mRYLQAIHKETLRLYPAiPFNMRVALSDTTLPSGggpsgtqpvHVKKDTIVAYSPLYMHRSdlypdayadgtpFSDPREY 469 Aspergil...
EAA59226            383 mKYLNAVLNESMRLYPVvPFNVRFSLKDTTLPRGggpdglapvAVRAGTRVVYSTMIMQRSpenydp-psapnYFDPAQW 461 Aspergil...
EAA60936            672 mPYLRHTINEVLRLYPAvPYNIRFALTDTTLPIGggvngdlpiTILKGDAVAYSTYAMQRRadlyp--pvsekFADPAIF 749 Aspergil...
EAL22122            389 lRYCRAFINEVLRLFPPvPLNIRRTLRPSLLPTPnh-----laYMPANTSIILATILMQRDpa--------vwGEDAQVF 455 Cryptoco...
EAA28794            374 mKYLQNVMNETLRLYPVvPFNVRMALKDTTLPRGggpdgsqpiVILKDTPVGYSPLAMQRRpdlyp--pvsekFPDVEMF 451 Neurospo...
EEQ39970            366 cTYLRWVLNEGLRMYPPvPSNLRQAVRDTTLPKGggpdgespvLVRKGQYVALHIYSMHRSee--------fyGKDALSF 437 Clavispo...
EAL86290            360 aTYLRYVFNEAMRVYPPvPFNARTANRDTYLPAGggpdgqsgvLIRKGQRVIFASWGSHRStr--------sfGADALEF 431 Aspergil...
WGS:AACS:CC1G_05498 401 mRYLRAFINEVLRLYPPvPFNTRRAINDTVFTTKdgr---pplFIPGDTQVGYSVWDMHRRkd--------lwGPDAYEF 469 Coprinop...
Feature 1                                              ###   #####  ##                                  
P30611              425 RPDRWfdss-------------mknlGCKYLPFNAGPRTCLGQQYTLIEASYLLVRLAQTYEtves-------------- 477 Candida ...
AAL67906            427 DPDRFldarvq---------ryltpnPFIFLPFNAGPRICLGQQFAYNEMSFFVIRLLQHFDevqlcedalapdcrvpda 497 Phaneroc...
EAL85431            470 HPHRWmypgsktadsekinegpwipkPWTYIPFNGGPRICLGQQFALAEMGYTLVRIFQKYKc----------------- 532 Aspergil...
EAA59226            462 NPERWlsgw--------------qpkPWQFIPFNGGPRICIGQQFAMIEMGYTVVRILQAFEriqavp-----------e 516 Aspergil...
EAA60936            750 SPERWevw---------------spkPWHYVPFNGGPRICIGQNFALAEMGYTIVRILQRYEri---------------- 798 Aspergil...
EAL22122            456 NPDRWleggg------------lgkeKEGFMSWNLGPRMCLGQSFALAITHTFLVYFFRHIAhvgtlvghn------ttv 517 Cryptoco...
EAA28794            452 SPDRWfhw---------------qpkPWQYIPFNGGPRICIGQQFALTEMGYVLTRLFQRYDrvvsy------------- 503 Neurospo...
EEQ39970            438 RPERWadl---------------skiGWAFMPFGSGPRICLGQQFALTEASYILVRMVQDFPhias-------------- 488 Clavispo...
EAL86290            432 RPERWegl---------------kseSLGYIPFSAGPRVCLGQQYALLEASYATIRIIQTFErle--------------- 481 Aspergil...
WGS:AACS:CC1G_05498 470 DPDRFlderlh---------kyltpnPFIFTPFNAGPRICLGQQFAYHEASFFLIRLLQQFSkfslapdaqpagtippes 540 Coprinop...
Feature 1                                              
P30611              478 -hpdsVYPPRKKAl------INMCAADGVDV 501 Candida tropicalis
AAL67906            498 wrgapGRKGVERFwpk--ahLTLYAKGGLWV 526 Phanerochaete chrysosporium
EAL85431            533 ----lERRMRAEDgglmranIVLTPAQEVNV 559 Aspergillus fumigatus Af293
EAA59226            517 agksvVEDPRLRFe------VTLTPASELNC 541 Aspergillus nidulans FGSC A4
EAA60936            799 ---eyVGDWERQFhk---seIVGTPGMGVKL 823 Aspergillus nidulans FGSC A4
EAL22122            518 qlaldAQPPETVLp-----kEWMTPEGGDGR 543 Cryptococcus neoformans var. neoformans B-3501A
EAA28794            504 mdeidGGKPRMKTd------IVLMPGDGVKV 528 Neurospora crassa OR74A
EEQ39970            489 --hnkTYPPRTYSr------STMHYIDGIRI 511 Clavispora lusitaniae ATCC 42720
EAL86290            482 --nrdVRPWTEKIg------LNLSNKNGVLV 504 Aspergillus fumigatus Af293
WGS:AACS:CC1G_05498 541 wktceGRKGMEKIwpg--tnLTLIVKGGLWV 569 Coprinopsis cinerea okayama7#130

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