Conserved Protein Domain Family
CYP67-like

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cd11061: CYP67-like 
cytochrome P450 family 67 and similar cytochrome P450s
This subfamily includes Uromyces viciae-fabae cytochrome P450 67 (CYP67), also called planta-induced rust protein 16, Cystobasidium minutum (Rhodotorula minuta) cytochrome P450rm, and other fungal cytochrome P450s. P450rm catalyzes the formation of isobutene and 4-hydroxylation of benzoate. The gene encoding CYP67 is a planta-induced gene that is expressed in haustoria and rust-infected leaves. The CYP67-like subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410684
Aligned: 74 rows
Threshold Bit Score: 365.392
Created: 17-Sep-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
heme bindingputative
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                               #   #      #          
O00061    107 GDWVRIG-PNELCTtsIEALSTIMGpkg-wpKGPSYDSGItkgdsggdsvltikNLPEHATRRRIWNKAFTpnai----- 179 Uromyces viciae-fabae
EAA58076    6 GDFFRTG-PREICIvrKSAVPLLLSpqskcgKSTFYAQAQteaeyc--nvhqtrDFEDHRRRRKAWDRGLSvkal----- 77  Aspergillus nidula...
EED15645  126 GDYVRVG-PRELSIanPRALPIIYGhasqttKGPFYDGAKpyisv-----hstrDKRDHARRRKMWDRAFSsksl----- 194 Talaromyces stipit...
EAT80464  131 TDVIRTG-PREVTVycTDAIPLIHGpmsrcrKGPWYSGSShiggts---tqttrNKDEHKRRRKAWDHAFNakal----- 201 Phaeosphaeria nodo...
EEU37524  139 GDFVRVG-PREISItrESAISIIYEppnqcvRSTWYSQVSddvrki--slhttrDLTAHKLRKKAWVRGLGfral----- 210 Nectria haematococ...
EAU31614  135 GDIVRVG-PRELSVanPEAFRAIHLsss-cgRGPWYNVTApmisl-----qmerDVKRHGERRRAWDKAFDnrgkpdsqt 207 Aspergillus terreu...
EEA19212  136 GDYVRTG-PRELVIfdPAALTPVLGfasitgKGPFYDSMEtsvn-------tsrDKEFHRKRRKIWDNAFKksl------ 201 Penicillium marnef...
EDU39892   12 GDYVRTG-PRELTVfdAAAIQPILGvhskttKGPFFDVMErslh-------lnrDKTFHRQRRRVWDNAFKasl------ 77  Pyrenophora tritic...
BAE58815   70 GDFVRTAlPLSYGPqtGCRRSTWYGhvd-vdDTKICMALSh-------------DFNDHRRRRRAWDRAFSiisl----- 130 Aspergillus oryzae...
EEQ29815  116 HEAVQGLhAEHVNN--ASAVRDIHGygsvclKGPFYDLNYpsrsl-----qmtrDKAFHSSRRRTWDRGFSpkal----- 183 Microsporum canis ...
Feature 1                                                                 #                   
O00061    180 -------------------ngyLPSIEIRLEEMLSVIDTEikkgesvdlclQLGCFVYDTMCDMAFGalagsafsktqed 240 Uromyces viciae-fabae
EAA58076   78 -------------------atyEPSIRAKADLLVLHIEKNrgrai--datkWSMFLSFDIMGKVGFGkefnnlstgvehp 136 Aspergillus nidula...
EED15645  195 -------------------rdyEQRVSRYAAQLLSVIADNvgkpi--dmsrWFNYYSFDVIGDLIFGksfdmlitgkday 253 Talaromyces stipit...
EAT80464  202 -------------------reyEPRLNRHALALMSQLKEQaksps-vrftnWANFYSFDVMGDVGFSrsfgmvekgeede 261 Phaeosphaeria nodo...
EEU37524  211 -------------------aiyEEKIASKVEILMSQIAEKqgtpm--dmtlYAAFFGFDVMGQVGFSkdfnmldsgykhp 269 Nectria haematococ...
EAU31614  208 ykknkqlramlipmclsalgdyMTRVNAHTENFCAAIEDSvknntslnvtkWIHLYSFDIMGDLAFGssfdmlqsgtfhy 287 Aspergillus terreu...
EEA19212  202 -------------------sdyGPRIEEFTGQLIERIEKNdgkpi--llneICIHYSYDVMSALAFGdpmgflkgdsndv 260 Penicillium marnef...
EDU39892   78 -------------------sdyAPQIEHFTDQLLIRLRNEegqpi--plleYTTYYSYDVMAALAFGkpmgfikgeqsdv 136 Pyrenophora tritic...
BAE58815  131 -------------------svyEPRVIAQAKKLMAQVEANqgkpl--dattWSMLFTFDIMGDIGFGknfgnlttgkahp 189 Aspergillus oryzae...
EEQ29815  184 -------------------seyEPRVFQHCLELVKQLSRLsgtpv--digkWFKYFGFDVMGDLSFGrsfdmlr------ 236 Microsporum canis ...
Feature 1                                                                                     
O00061    241 kyrilthmgrvvrqvgIVRNMPWLTPIVKaw-psSHRREQNEFKEFTKSMFLRRknqg---------------------- 297 Uromyces viciae-fabae
EAA58076  137 ---gikaihdhmailgVMCHVPWLLNLISnl--pGASFSMAEFFKWCEDEIVQKhrswd--------------------- 190 Aspergillus nidula...
EED15645  254 ---mlktlhkdmqsmgPFLHSMWILEIFKli--pGLNSSLLVYFEWVKEQIENRmkne---------------------- 306 Talaromyces stipit...
EAT80464  262 ---mikllhesmsplsIFGHLNWGLNLATrt--aAGAKALIDHIDWTSKVMEERakvsisglt----------------- 319 Phaeosphaeria nodo...
EEU37524  270 ---aiqalhenmvavgVLSTVPWLMSMLGki--pGATGSYARFADWCAREFQAKrankei-------------------- 324 Nectria haematococ...
EAU31614  288 ---ffnlthktleliaIFSRLVWLFPVVKav--pFLSNDYKSFRKWVGSHVQRRiavp---------------------- 340 Aspergillus terreu...
EEA19212  261 ansvldniqkgvdaigLLLHVPWLMGTLTtf--sWAIGPMRQWNEYSEQLVVLRkemk---------------------- 316 Penicillium marnef...
EDU39892  137 aasilatftnsvqalgYMYHMPWLMNAIGvl--tSIAGPMKEWRDWSVSQMRIRmkihlq-------------------- 194 Pyrenophora tritic...
BAE58815  190 ---aisairdnmrviaVVSHLPWLLNMLGki--pGAAAGYQGFFKWCTDQVETKrkvlspryafglavdetsvypdatqq 264 Aspergillus oryzae...
EEQ29815  237 ----------tsnphfLFGMMEAGKPVVGtlisvPWLFILFQKLPGISRLGTTR-------------------------- 280 Microsporum canis ...
Feature 1                                           ##  ##  ##  #                             
O00061    298 ----lgkqLDVFHYLLGEDTEtgt--rltEAELAADSTLLVITGADTTRTVLLAFFLYLLKHPnymeQLQAELLAAPdls 371 Uromyces viciae-fabae
EAA58076  191 ---iketpQDITSWLLKAYVHkevsaaptANALHEDSRAVIVAGSETTATTLASILYFLCKNPeilaKLQLLLDEAMpgg 267 Aspergillus nidula...
EED15645  307 -----penPDIFTQLEADFRNtkqs-kkdQLHFHGEVNVGLVAGSDSTASTLTNLFYELANAPeftcLLQAEIDSVKert 380 Talaromyces stipit...
EAT80464  320 irkitpkeNDVFTWLLDPNATr------vSPELNADSRLLVVAGSDTTAATLAWIACELCKQPeiqaKLRKEIDAITpsk 393 Phaeosphaeria nodo...
EEU37524  325 --lkdhdpRDVISWLLRAEDEndrsappgEGAFQEDSRLMIVAGSDTTAVALTNALFFLTKSPtcyrKLQAAVQAQFpeg 402 Nectria haematococ...
EAU31614  341 -----ppvRDIFSWILNDYQRkqnpswqdTENLYGDASLIVIAGSDTVAGTLICLLYHLASSPdvckKLRDELHSCAker 415 Aspergillus terreu...
EEA19212  317 -----npkPDLFGHLLDNTEDta----tgRALLNSECRLIVGAGSDTTATALTFLFVQLALYPewilRLREEMDPIFsas 387 Penicillium marnef...
EDU39892  195 ---vrdakPDLISHLITSTPKth----egRELLFGESRLIISAGSETTSTALTFIFMQLATHPhymtAVRNEFLAKHpsh 267 Pyrenophora tritic...
BAE58815  265 swdhdeypQDIISWILKAFIDndvsappsEPALHDDSRVVVIAGSDTTALALASIIYFLAKHPqilqKLQAELDNAMpng 344 Aspergillus oryzae...
EEQ29815  281 --------PDLFSYILGSDLSea----isDGDLTYDAELAIVAGSETTALNLTTVLYLLALNPdqkkALQAEIDLLVpti 348 Microsporum canis ...
Feature 1                            #         # #                           #                
O00061    372 pp------slsrLEYLNACLQETMRLQPPspANLQRICPPgGAVICGr----qIPEGTKVRFSNYAIHrDERYFsRAEEF 441 Uromyces viciae-fabae
EAA58076  268 ssew-tydkiktISYLDDIINETLRLRPAilTGGYRVTPAeGLQVDEv----yIPGDVNVFVPTQLIQtDERYYvDAKRF 342 Aspergillus nidula...
EED15645  381 yq------elsqMQLLNAAIDETMRLHPAipSGMQRLTSQkGVMIDDv----yIPGNCLVQIPLYSIFrDERSFaQPNEF 450 Talaromyces stipit...
EAT80464  394 sfle--vedvanCAFLDGVINEALRLHPAvpSGVQRETPPeGITLPNgt---yIPGNIIIWMPIHCIQrDPRYFaQPLTF 468 Phaeosphaeria nodo...
EEU37524  403 vkdw-tyekiklIPYLEYVIHETLRLKPSapGGLSRLTPPqGLQIDEv----fIPGDTIVSVPTYTIQrDERYWeNALEF 477 Nectria haematococ...
EAU31614  416 adtelrpdelakLPYLQACIDETLRLWPAvvDGLQRETPPeGLTIGTekkstwIPGNVIIKTPSYTLCrDPRAFsRPDEF 495 Aspergillus terreu...
EEA19212  388 gy-----ectrtYPVLDAIINESMRLHPSvfFGSQRETPPqGMQIGEt----fIPGNTIISIPGYQLArDERNFvLANDF 458 Penicillium marnef...
EDU39892  268 t-------cqnaLPFLEAVIQESMRMWPSvfFGSQRVTPPqGVEISGh----lIPGNIIVHIPLFPLFrDPRNFvCPDEF 336 Pyrenophora tritic...
BAE58815  345 prsw-tydkaktICYIDDIIHESLRLRPSvsGGGYRVTPAeGLQIDEv----fIPGDVNVFVPQQLIQtDERYYkFSKEF 419 Aspergillus oryzae...
EEQ29815  349 dqls--hqklagSPLLEGCINEGLRLYPPvpSGVQRLTPPqGAMIADr----wIPGDTIVSTPTFSLHrDSRYFvKPDQF 422 Microsporum canis ...
Feature 1                                  ###   #####  ##                                    
O00061    442 RPQRWlqkakddlgnqgeekerldQRAFFGFLIGPGACVAKNLAWMEMRLVVATILTNFDlsfapgfDPVAFESSWTda- 520 Uromyces viciae-fabae
EAA58076  343 VPERWnekke----------miqdGAPYFPFLYGPYVCPKKNLALMSLRISVSKLAQLYDihfapgeNGELFETRTLdtf 412 Aspergillus nidula...
EED15645  451 IPQRWtdrpd----------lvkdPSAYAPFGLGPFACAGRQLAYMEIRRITTELLSRYDislakdqTREAFYEGQRds- 519 Talaromyces stipit...
EAT80464  469 LPERWtdeqp---------eavieKRAFMPFSTGIYNCVGQKLAMMELRSVTANLIKLFEvefaegeDGKEILEKSRdc- 538 Phaeosphaeria nodo...
EEU37524  478 RPERWenl-------------npeKVAWIPFSRGQYSCPGKNLAFMELRMVISRIALEYSlafppgdDGEAFDKGARdt- 543 Nectria haematococ...
EAU31614  496 IPERWttepe----------lildASVYAPFSLGRFSCVGKRLAMVMMRRFISSIILRYElevlfksAQDAFERQVKey- 564 Aspergillus terreu...
EEA19212  459 LPERWyskpe----------ltinKTAHMPFLIGPFNCAGRNLAMMELRSVVARVVHEFDvs----fPKGVEFDAVNy-- 522 Penicillium marnef...
EDU39892  337 IPERWttrpe----------lvrnRAAYIPFSTGAHSCAGKKLSLMELRSVVGRVISEFDvvleegtDVGAFWEGVKdh- 405 Pyrenophora tritic...
BAE58815  420 IPERWgekkv---------ewgtdKAPYFLFSLGIYGCVGKNLAMLSLRVAVSTLAQRYDir---frTGDILERCIGy-- 485 Aspergillus oryzae...
EEQ29815  423 IPERWsskpd----------liirKDAFSPFLAGRYSCAGRPLAMMEMRMLLAMVVRLFDfn----fPKESRVGAEKlyd 488 Microsporum canis ...
Feature 1              
O00061    521 ylLLIEEPF 529 Uromyces viciae-fabae
EAA58076  413 ttTLPPLHV 421 Aspergillus nidulans FGSC A4
EED15645  520 ftVVCGKLQ 528 Talaromyces stipitatus ATCC 10500
EAT80464  539 ftTNVGKLD 547 Phaeosphaeria nodorum SN15
EEU37524  544 ftLNVPELP 552 Nectria haematococca mpVI 77-13-4
EAU31614  565 ftLTPPDLQ 573 Aspergillus terreus NIH2624
EEA19212  523 -fDRVKDHF 530 Penicillium marneffei ATCC 18224
EDU39892  406 ftAGPPRMM 414 Pyrenophora tritici-repentis Pt-1C-BFP
BAE58815  486 -iHHFSAAF 493 Aspergillus oryzae RIB40
EEQ29815  489 gkGGFRDYF 497 Microsporum canis CBS 113480

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