Conserved Protein Domain Family
CYP59-like

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cd11051: CYP59-like 
cytochrome P450 family 59 and similar cytochrome P450s
This family is composed of Aspergillus nidulans cytochrome P450 59 (CYP59), also called sterigmatocystin biosynthesis P450 monooxygenase stcS, and similar fungal proteins. CYP59 is required for the conversion of versicolorin A to sterigmatocystin. This family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410674
Aligned: 27 rows
Threshold Bit Score: 415.885
Created: 17-Sep-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
heme bindingputative
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                  #   #      #       
Q00714     43 FYINMWPFSgTWLVVATPSGAAQIQSlnlskp------nilrrPLETITGGPSLMsmhgETWKRWRALFNPGFnpnylig 116 Aspergillus nidula...
EAQ82998   77 MFLDLRPASyPMVLVNSHEVAEQVTRvs--------------kMFAWSTPKSPTMgalkEDWKQLRKRFNPGFapqhlmt 142 Chaetomium globosu...
CAK39815   71 MFFDLRPVQfRLCVVGSHEIAEQVSRstksfpys-mqksptmgALEPLLGPYSIItqegEHWKGLRKRFNPGFapqhlit 149 Aspergillus niger
EED11475  131 VLMDFRPICrPVVFIACHEVAEQISRptslfrts--vpkvdlgYLKPVIGPTSILsaegDKWKALRRTFNHGFslqhllt 208 Talaromyces stipit...
EER43541   70 AFFDLRPIQyPLILIGSHEIAEQVSKasamfkys-vpksptagMLIPIVGKKSIIltndETWKHGRKKFNAAFspsnlvt 148 Ajellomyces capsul...
EEY19401   81 MLLDIRPFNhPILFIRTHEVAEQVSKqtkafpys-fgkpttmdFLEPLIGPSAIIritgSHWKGLRRRFNPGFapqhlms 159 Verticillium albo-...
CAP94134   77 FIVDLRPVShPMCVIGDHNVAEQISKisklfpfs-ppksftshWYRDLMGPLSIVlaerEEWKGLRKQLNPGFahkhlis 155 Penicillium chryso...
EAT88703   50 MFFDTRPAQwPLVLITSHAFAEQISKatkdqpysttksptiqaGLGRLVGRYSMLseeaESWKSLRRRFNPAFapqhlmt 129 Phaeosphaeria nodo...
EEU37617   68 IFVDMRPVSnPVALITSHDVAEQVAKssalfpws-tpktptmkDIIHLLGPSSLIsaegEDWRKLRKRFAPGFapnqlmt 146 Nectria haematococ...
EAA61501   74 FYLDLWPLApPQLVIAHPELATQIVHkmnlpke----savmqkWTGPILGEKSMVsangHDWFIARKSFTPGFqprklqq 149 Aspergillus nidula...
Feature 1                                            #                                        
Q00714    117 lAPLIADEVVVFCEQLRQKARtgtvfqLEPLTLRLTVDTICSVTldsQLHHQTQDHPLASalqrq-----iewasFGTTF 191 Aspergillus nidula...
EAQ82998  143 lLPCIIDKTDIFMEHLDRLASsgeefsMLKHTINLTFDIIGAITmdvDFDAQKSESSSQGefirly---dellkmYGQED 219 Chaetomium globosu...
CAK39815  150 lLPCILDKAIQFTDILDAYARsgeelsLDERCVSLTFDIIGAVTmdkDFHAQLDRSKQDElvrlyr----elttsYRSGS 225 Aspergillus niger
EED11475  209 lLPTILNKTMIFVKHLDRLSEsgaeksLVSLTVNLTYDIIGAVIldiDMDAQHTDPCQRGelvraft--dlldayWDDKI 286 Talaromyces stipit...
EER43541  149 fMPKILDKTMEFLALLDGYVEsgeefcLAEPCIQVTFDIIGLAVlniDFKSMQGQDKVSViv-----------raFRSLL 217 Ajellomyces capsul...
EEY19401  160 lLPLITEKTEPLLASLDRLVAsgesftLEPLLTGLTFDIIGAVTmgiDFNAQLPDDKQSEfi-----------rmYRELL 228 Verticillium albo-...
CAP94134  156 lMPCILDKTQLFLTKLDHYAStgeefpLDELCTNLTFDIIGAVTmdiDLDAQLGEEKQSAivrl-------frklASTWR 228 Penicillium chryso...
EAT88703  130 lLPVVLDKTYTFMEKLDALAKsgkpteLEPYCTNVTFDIIGQIVt--DIDCKAQDESIQGdeivknfrllgatwsEDTGL 207 Phaeosphaeria nodo...
EEU37617  147 lLPCILDKTEPFINRLEDHARsgeqfsLLTLIVNLTIDVISAVAmdeDLEAQTIDPSGQSqvirlf---mellstYSSRH 223 Nectria haematococ...
EAA61501  150 hIPHIVDETQAFADILREHFHmndifkMEDLVARMIFNISAGVIlgiKCNAQRDDDEFLElfr---------kqaALAPQ 220 Aspergillus nidula...
Feature 1                                                                                     
Q00714    192 NPFKRYLTv--------rPLVMWYNNRLMNRFIDQEVDRAYReqsgrqsksvislal-----------rdymkekdgsle 252 Aspergillus nidula...
EAQ82998  220 SRFPWWMSpm-------rEWRRYTLSNQIDRLLETMIRAKHAehnhhqqqqhttttktkkp---rdvlslslqgsdtldr 289 Chaetomium globosu...
CAK39815  226 GIQWGWLDvr-------vLWRRRVLTRRIDHLISEHIKTKFDelkskstekrsrsvl-----------slslqdidqlnt 287 Aspergillus niger
EED11475  287 HLPWWFNPf--------gELRRRRLGKRVDTILKSIVRRKHEeqqqahrtgqktqslps------siislslqdtpvlsq 352 Talaromyces stipit...
EER43541  218 STFPTTFAfdswftnpkgHYRRIALVKTLTASLTPIVKEKFDmahnnirldnkvvdrs--------vmamglrqvhtltp 289 Ajellomyces capsul...
EEY19401  229 FTYKGDDGgtpafaqplkRWRRRRMAKRVDAHLSQFVRDKYNelkregkksrtvla-------------lslqdedhvsd 295 Verticillium albo-...
CAP94134  229 SGYSGWKVi--------lPLQRKLISRQLSAHIKECIKEKFEerstsqnssrsvla-------------lslaetqeltp 287 Penicillium chryso...
EAT88703  208 AMFKWLNAs--------kHFKRYLYSTRLDVAIKKCIQAKFDamqadkshskdrsvl-----------alslkdtetltp 268 Phaeosphaeria nodo...
EEU37617  224 NLPWWLAPs--------lGAKRRRLAGQVDGMLRDIVQRKFEehqktsggnkprnil-----------slsfqdideltp 284 Nectria haematococ...
EAA61501  221 DFWSRYLYdvs----prrYYRKWSNGRALDRYVGRLVDQRVVsgpaanpdqktkyyaiddaiatsrtlnkniphtssldk 296 Aspergillus nidula...
Feature 1                ##  ##  ##  #                                                        
Q00714    253 dfKRRVAPQLRVFLFAGRDTTSSTLLYAFYLLSRHPEALAKVRLEHDQVFGpyhqqvhe----kihqdakLLNQLPYTTA 328 Aspergillus nidula...
EAQ82998  290 alLTETRDQIKTFLFAGHDTTGILLAWLFYEFSRSPHVLQAVRDELDELFGpdaspaavrarllapggeeLINRMRYATA 369 Chaetomium globosu...
CAK39815  288 rvIQETCHQLKSFLFAGHDTTSIVLQWSFYVLSRTPRVLDKLRRELDDLFGpdpspaavqekllapggddLLKRMSYTSA 367 Aspergillus niger
EED11475  353 evLDRTCDQLRTFLLGGHDTPSATLAWVFYELSRTPRSQSAVRAELDVLFGpgtdadavrtqlaspagpeLLSRMSYITA 432 Talaromyces stipit...
EER43541  290 qvLEECVDAVKSFLFAGHDTTAVVLQWSIYELSRTPRALAAMRKELDEVFGpdadpksva--kqlledsnKLQNLQYTSA 367 Ajellomyces capsul...
EEY19401  296 amISETIDQLKSFMFAGHDTTSILLQWALYELSRTPRALKTLRAELADLFGadatpetvr-avfeargddIMPKMTYTSA 374 Verticillium albo-...
CAP94134  288 evLDRICDQLKTFLFAGHDTTSILLQWTFYELARTPHVLRRVCMELEDIFGptshpthir-eqilehgesVLQRMIYTSA 366 Penicillium chryso...
EAT88703  269 fiMQNIADQVKTFLFAGHDTTSILLQRLFYTLSIHPSCLAKIRAEHDSIFGdsdprdv-----fqarpddTMKALVYTSA 343 Phaeosphaeria nodo...
EEU37617  285 elLSHTSDQMKSFFFAGHDTASILLSWTFYELSRSPRVQKAVRAELDELFGpdpdpsvvr-snlyangedLVRRMTYVSA 363 Nectria haematococ...
EAA61501  297 ytRDMLITSVKTLIFAGHDTSASTLCYTFAAISKHPQVLNTLRKEHNALFGtdpsaaad----llrddpnLVNNLPYTLA 372 Aspergillus nidula...
Feature 1          #        # #                            #                                  
Q00714    329 VLKETLRLFPP-SASMREGRPGveitdd--ngqvyPTAGCNVWTLTVALHHNsa-hWAEAESFIPERWLvgsdh------ 398 Aspergillus nidula...
EAQ82998  370 VVKEVLRVYPP-AGTARMAPPGtgftvt-aegksyCLDGAIIYNCATIIQRDravfGETADDFVPERWLgdkagimsaga 447 Chaetomium globosu...
CAK39815  368 VIKEILRLYPP-SGSARYMPPGtgftvqlpdgktlCLDGVVVYNNSTLVHRDekvyGPTKDEFIPERWLgdadtglglst 446 Aspergillus niger
EED11475  433 VIKETLRLHTP-ASTARRSPPGtglvvrtptgenlNMDDVIIYNCNSIIHRDrvifGATADNFMPERWLddsnn------ 505 Talaromyces stipit...
EER43541  368 VIKESLRLYPP-AGSARMVAPGsdfrln-tkngplDVGGMILYVCHYAIHRDptvyGETADVWIPERWLgqtsttsenya 445 Ajellomyces capsul...
EEY19401  375 VIKEALRLYPP-AGTARWCPPGsnfhlkladgsslCVDGTILYNCHTLIQRDeavyGSTVNDFVPERWLgntstsvsndd 453 Verticillium albo-...
CAP94134  367 VVKEILRLYPP-AATARFSAENtglsvrlpdgqdvCLDGIMLYNCQSIIQRDqavyGDKSDQFIPERWLetgs------- 438 Penicillium chryso...
EAT88703  344 CIKEALRLWPP-AGSARMSHNGlklrts--dgeevCLDDCVLYMCQHLIQRDrkvyGDTADDFVPERWVddidtssasvd 420 Phaeosphaeria nodo...
EEU37617  364 VIKEVLRIHPP-AGTGRYAEPGsgftvrtstgeelCLDGTIIYNCQHIIHRDptvyGTSANDFVPERWLgetsa------ 436 Nectria haematococ...
EAA61501  373 VIKEALRLWPPtGISLRRGQPDqtlfa---egkewPTYPFAVLVNNCATMRRed-lFKDAERFYPERHLvndptd----- 443 Aspergillus nidula...
Feature 1                                ###   #####  ##                                      
Q00714    399 -----------------plypaKGAWRAFEFGPRSCIGQTLAMLELRVALAMTLREFDIap-----------ayDKWDHI 450 Aspergillus nidula...
EAQ82998  448 de-------esekrdeagrkfpPGAWRPFERGPRNCIGQDLATIEARVIVAAVARRYDFvkvg--------lgeLDLNEK 512 Chaetomium globosu...
CAK39815  447 dnv-----edkgngpvatacipASAWRPFERGPRNCIGQELANLEARVILACTVRRFDFekvgvgaiardatgaPILDAK 521 Aspergillus niger
EED11475  506 -----------------ktsipPTAWRPFERGPRACIGQEFASIEMRIIIAVVARQYEFskvg--------lgeLALDAT 560 Talaromyces stipit...
EER43541  446 pssvd-kdknsstagaegqkipISAWRAFERGPRNCIGQELANLEARAILAMVARRYEFtkvgigs-lalkdgkPVLDQH 523 Ajellomyces capsul...
EEY19401  454 eeedsnnaekatigkasesdipVSAWRPFERGPRNCIGQELANIEARIILATVVVKYDFvkvgmaeaklgqdgkPLLDDK 533 Verticillium albo-...
CAP94134  439 -------------------tipGSAWRPFERGPRNCIGQELANIEALVILACATRRYNWekvg--------lgaTKRDES 491 Penicillium chryso...
EAT88703  421 a----------dgsatgsskipISAWRPFERGPRNCIGQELANIEVRVILACTLRRYDFvkvgrgeierdekdrPIVDEK 490 Phaeosphaeria nodo...
EEU37617  437 ------------------wgfiPSAWRPFERGPRNCIGQELANIEARVIIAIVARHFDFvkvglgeleldengrPILNDK 498 Nectria haematococ...
EAA61501  444 -----------------pyfvpRDAWRPFEKGPRMCLGQTLALMQLKIALVMTVRTFDFei-----------vyEEGTFM 495 Aspergillus nidula...
Feature 1                                      
Q00714    451 YPNDavkefnghra-yqaekggggAHPADGMPC 482 Aspergillus nidulans FGSC A4
EAQ82998  513 GQPVmndkgqykvkaemyntaqvtAKPVDAMRM 545 Chaetomium globosum CBS 148.51
CAK39815  522 GQYEveself--------ntmqvtAKPIDGTVV 546 Aspergillus niger
EED11475  561 SGLPilr---------------hdARPVDGIMM 578 Talaromyces stipitatus ATCC 10500
EER43541  524 GQFEvtkplf--------gtfnvtMKPVDGTLM 548 Ajellomyces capsulatus H143
EEY19401  534 GQHVsdtqlf--------sdrqitARPNDGIEV 558 Verticillium albo-atrum VaMs.102
CAP94134  492 GAPIekengqyevqselyntleitSKPVDGMRM 524 Penicillium chrysogenum Wisconsin 54-1255
EAT88703  491 GKYRtkselis-------vsfvtvEGFAHGLIC 516 Phaeosphaeria nodorum SN15
EEU37617  499 DQYKvk----------------seLYPLTPFRC 515 Nectria haematococca mpVI 77-13-4
EAA61501  496 YQVLdv-----------------tAKPSLGLPT 511 Aspergillus nidulans FGSC A4

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