3B98,3B99,3SN5,3B6H,2IAG


Conserved Protein Domain Family
CYP7_CYP8-like

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cd11040: CYP7_CYP8-like 
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cytochrome P450s similar to cytochrome P450 family 7, subfamily A, polypeptide 1, cytochrome P450 family 7, subfamily B, polypeptide 1, cytochrome P450 family 8, subfamily A, polypeptide 1
This family is composed of cytochrome P450s (CYPs) with similarity to the human P450s CYP7A1, CYP7B1, CYP8B1, CYP39A1 and prostacyclin synthase (CYP8A1). CYP7A1, CYP7B1, CYP8B1, and CYP39A1 are involved in the catabolism of cholesterol to bile acids (BAs) in two major pathways. CYP7A1 (cholesterol 7alpha-hydroxylase) and CYP8B1 (sterol 12-alpha-hydroxylase) function in the classic (or neutral) pathway, which leads to two bile acids: cholic acid (CA) and chenodeoxycholic acid (CDCA). CYP7B1 and CYP39A1 are 7-alpha-hydroxylases involved in the alternative (or acidic) pathway, which leads mainly to the formation of CDCA. Prostacyclin synthase (CYP8A1) catalyzes the isomerization of prostaglandin H2 to prostacyclin (or prostaglandin I2), a potent mediator of vasodilation and anti-platelet aggregation. This family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410666
Aligned: 70 rows
Threshold Bit Score: 252.286
Created: 3-Apr-2007
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
heme bindingchemical
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
3B98_A     44 LTRMKEKH----GDIFTVRaagLYITVLLdSNCYDAVLSDvasl---------------dqtSYAQVLMKRIfnmil--- 101 zebrafish
3SN5_A     39 LRANQRKH----GHVFTCKlmgKYVHFITnPLSYHKVLCHgkyf---------------dwkKFHFALSAKAfghrsid- 98  human
EAL93738   39 LWRIWRNYfnniQDPFALSianSLIYVITkPQDVAEAYRNtd-------------------tLSFNEFVQAMmracgnte 99  Aspergillus fumiga...
CAP73657   18 LERNKLSGd--nRQPYALQaagTSFYVIShPKHIAELSRNtqnf---------------sfvEFSVDIVKATgmspegia 80  Podospora anserina...
EEA23201   80 LIARARDHfrytQEPIALTafgVTFYVVTqTKQSAEVYKNkdtl---------------sfeNFVQTLMRNNgneedviq 144 Penicillium marnef...
EEQ35349   75 LLTRARQYfgdtREPFAITianQLFYIITnSNDVSSVFRNstsl---------------tfeIFAQEILHDLgcsessik 139 Microsporum canis ...
EDN95674   81 LFKRAREYfgntREPFAITimgQQIYVVTnPEDLPTLYKStstltfdgfikdffkkegvtpeAIEIMFTKQAksqk---- 156 Sclerotinia sclero...
EEQ35370   61 FDTFGNNPl---REPFSITlagEEVYVVVnPNDVAQVYKNnt-------------------sLSFDVFVQDLmlscgtdt 118 Microsporum canis ...
BAE58483   88 IRTCGKRFg--tLEPFSMIiagDRYYVITsPEDTRPFFADvkam---------------ttdGFLDRALLAFgcaperlh 150 Aspergillus oryzae...
EED20043   29 IESLSKKNgs-sKEPFAITmagKPIYLLTnPKDIAETYRHed-------------------tLSMDMVVKDLysrtgism 88  Talaromyces stipit...
Feature 1                                      #  #   #                                       
3B98_A    102 -------------------------pshnPESEKKRAEMHFQga----------------slTQLSNSMQNNLRLLMTPS 140 zebrafish
3SN5_A     99 -----------------------pmdgntTENINDTFIKTLQgh----------------alNSLTESMMENLQRIMRPP 139 human
EAL93738  100 scvktmykp----lpkdkpgfpnphgkplATLARQMHIHQLYpgd---------------nlDFLEKQFLDWVEPRLTLD 160 Aspergillus fumiga...
CAP73657   81 ktynldpda---ldakvdhfkhpmkdkhfEHLNRQLHTTQLSpssqnnnlpsldqtiltwlqNHLTIPNLQEYSLVQNDL 157 Podospora anserina...
EEA23201  145 lmysslp--------adkigfpnpygeslGVLAQKMHAHQLHpgd---------------qlALLQSQVTQRIDYLLRMD 201 Penicillium marnef...
EEQ35349  140 qmygdpd--------pteagsqkphtkspSRMARDFHHHQLFpgg---------------llDTINIKFIQYFKGSLDLE 196 Microsporum canis ...
EDN95674  157 --------------------------kvlAHAGEDFFKQQLQpgg---------------hlQPLFNSIQMKISEVIQWD 195 Sclerotinia sclero...
EEQ35370  119 rtvekmseeppryipgrndsslnpsgkslVRLAVDFHHIQLLpgpn-------------sqaGPLIDVLLGHIKRGLAWE 185 Microsporum canis ...
BAE58483  151 tlwqr-----------ntptkvnpkgknlIHLTQDLFKHDLVpgp---------------tlNVLLERYQGALDELLSWD 204 Aspergillus oryzae...
EED20043   89 dkvnrlfia----npesphnkglprplhyIDISMEYFRWELSpge--------------sldRFVNEAAIPAILKAFDFD 150 Talaromyces stipit...
Feature 1                                                                                     
3B98_A    141 Emglktsew-------------kkdglfnLCYSLLFKTGYLTVFGaennns----aaltqIYEEFRRFDKLLPKLarttv 203 zebrafish
3SN5_A    140 Vssnsktaa------------wvtegmysFCYRVMFEAGYLTIFGrdltrrdtqkahilnNLDNFKQFDKVFPALvaglp 207 human
EAL93738  161 AlrrecpyaiqsgppavtkddgivlplmqWCSDYFTRAGQRAYFGpaldg------idpkLPQTFIVFDELSWQVlyqyp 234 Aspergillus fumiga...
CAP73657  158 Evnf-----------------------yeFVNTVFIRAGENAFFGpalar------nhpdVAHDFQIYDELHWRDlylfp 208 Podospora anserina...
EEA23201  202 Tllgtcspyatss-----spqhieiplykWCSDYFIRLGQHVYFGekldq------idpaLPDVFFVFDELIFKMlyqfp 270 Penicillium marnef...
EEQ35349  197 Yltsqpkyatri------asdavqvslfeMSSDLFTNAAQDVYFGkllrk------iapnLAYDLLEYDDLAWQVlfryp 264 Microsporum canis ...
EDN95674  196 Klsqkavisti--------qstkkvsllaFCHEMLVKPVSTAVFGnvlye------vepnLSEIYRKFDDNSWKMnyelp 261 Sclerotinia sclero...
EEQ35370  186 Tlsqgeclgsqk------sskgiqvsllgLCGRVLVEAGTKTYWGdklwg------ltpdMLKSFYALDRGVWKLlfqyp 253 Microsporum canis ...
BAE58483  205 Rlvgaypslvs--------tqteaislydICADFIANANQIVLFDralla------idpdMAVEMRTFTDELWKLvhrsr 270 Aspergillus oryzae...
EED20043  151 Rtpahsavlhnd------sddslvvslehLCIEALISGVVDIYYGpalwk------inpdFVHSFMMWERVNWKYifqlp 218 Talaromyces stipit...
Feature 1                                                                       ##  ##  #     
3B98_A    204 nkeekqIASAAREKLWKWLTPSGLDRkp-----reQSWLGSYVKQLqde-gidAEMQRRAMLLQLWVTQGNAGPAAFWVM 277 zebrafish
3SN5_A    208 -ihmfrTAHNAREKLAESLRHENLQKre-----siSELISLRMFLNdtlstfdDLEKAKTHLVVLWASQANTIPATFWSL 281 human
EAL93738  235 -eflagKMKSARNAIQRALKKYIQLPqesr--qgdAWFTKAMENEMral-gisEDDIATMLVTIYWGINTNTRKAAFWLL 310 Aspergillus fumiga...
CAP73657  209 -pflapELTAIKGKLTAQFKKYLALPkqerdkqnpSWFTPNFELALdkl-evgEQDKAVFFLMLYLATNTNTPKLLFWCL 286 Podospora anserina...
EEA23201  271 -gflshDMSKPRAQVIASLKKYFQVPqser-qssaAWLINAMEDEMrai-gvdDDNLAVVIFHLYLAINTNTRKSVFWLL 347 Penicillium marnef...
EEQ35349  265 -rflstKMVSARNRVFDGLEKYFASPtder--qdtVWFTPTLEKEMrna-glnNRDIAIMMMTIYWGLSTNTRKSVFWVL 340 Microsporum canis ...
EDN95674  262 -rlvapDVYDAKDEIRSVMLRYIQLPserr--sdaAWILHALENELrga-gisEEDIASFFFGPFWTINGNAYKHLFWVL 337 Sclerotinia sclero...
EEQ35370  254 -svfsrDALAARDTIIDILTQYYRLPreer--edcAWFTKSLETESrnl-glgESDMSAAILIIFFVVNGNTYKFCFWVL 329 Microsporum canis ...
BAE58483  271 -lvdttEVTRILRQYSSAFKSYLQLPpear--pneTPVIRTLLETYael-gihEDDRAAMLVMICWAGDANAYKAAYWVL 346 Aspergillus oryzae...
EED20043  219 -gflskDMLEAKRDLVDTFVTYFEMDrter--dcgNLFVNSVEDTLrea-gmgNEEIGRIFFLHSWAILGNMYKTAFWII 294 Talaromyces stipit...
Feature 1                                                                    # #              
3B98_A    278 GYLLTHP--EALRAVREEIqggkhlr-------------leerqkNTPVFDSVLWETLRLTAaALITRDVTQDkkiclsn 342 zebrafish
3SN5_A    282 FQMIRNP--EAMKAATEEVkrtlenagqkvslegnpiclsqaelnDLPVLDSIIKESLRLSSaSLNIRTAKEDftl-hle 358 human
EAL93738  311 TYILHYGpeHYVDIIRQETlpaflpdks--------ipdlnylhdNCPHLDAMWNETIRLSAySASVRFVTSDt-----i 377 Aspergillus fumiga...
CAP73657  287 AHLLSSPa-TCLDKIRAEIspaftgdelt-------dpsylltpgNCPTFEFFYLEVLRFRShSVSARVVTADtvl--pa 356 Podospora anserina...
EEA23201  348 TYLLHNP--TLLARYRQETgpafkdgeli-------dalyiqnpaTCPEVSMIWHETLRVSGwAASVRLIMEDt-----m 413 Penicillium marnef...
EEQ35349  341 AYIIFDA--ELIATIRREVsaafegek----------idvdhiteNCPRLRGVWDETLRTTAfSSSVRYVAEDt-----v 403 Microsporum canis ...
EDN95674  338 SYILFDS--ALHKSILTEVepavavgl----------egldsrleACPRLVATYEEVLRMNTsSVTVRDVLADt-----k 400 Sclerotinia sclero...
EEQ35370  330 CHLLSDP--SLYASVKKEVflenrtdg----------pslehltnKCPILDSVLSEVLRLYSsSASMRYITEDt-----l 392 Microsporum canis ...
BAE58483  347 AYILYDP--QLREIIRQETapavgpdgk---------ldwpylakRCPRLSSIYHEVLRLTKrDVIVRQVVRDt-----a 410 Aspergillus oryzae...
EED20043  295 AHLVYNP--SLLEAIRIEVtpaitkge----------vdhqylskDCILLDSLYADVLRATMsSPMVRDITETt-----t 357 Talaromyces stipit...
Feature 1                                                                     ###   # ###  ## 
3B98_A    343 GQEYHLRRGDRLCVFPFISPqmDPQIHQ---QPEMFQFDRFlnadrtekkdffkngarvkypsVPWGTEDNLCPGRHFAV 419 zebrafish
3SN5_A    359 DGSYNIRKDDIIALYPQLMHl-DPEIYP---DPLTFKYDRYldengktkttfycnglklkyyyMPFGSGATICPGRLFAI 434 human
EAL93738  378 IGGKILRKGNRLMIPYRQLHf-DESIFGvdyPVEEFRHERFmqkgrnl---------trsdnwRPFGGGTTQCPGRYVAK 447 Aspergillus fumiga...
CAP73657  357 PGSFLLRKGAKVLIPYRVFHf-DETIFGk--DAKFFKPERWeslpas-----------argvvRAFGGGKSICPGRYLAE 422 Podospora anserina...
EEA23201  414 IGGKVLSKGNRVIVPHRLLHf-DESIFGa--EPNSFRPERWqqkdnl----------erspswRPFGGGQTMCSGRYLAR 480 Penicillium marnef...
EEQ35349  404 IGNKILRKGHRIMMPYRQLHl-DESIFGe--RVAEFDSERFvkdtq------------lrrynMGFGGGATQCPGRHLAR 468 Microsporum canis ...
EDN95674  401 MGKVILRKGAKVFAPTRQLHf-DPLAFGt--NVDQFDPERFlrnkkl----------nksnsfRPFGGGITHCPGRWLAM 467 Sclerotinia sclero...
EEQ35370  393 IGGKILRKGRKIMLPYRQLHe-NQDVFGn--DFSKFRPTRFiekrnl----------trsssyRPFGGGATLCAGRFVAR 459 Microsporum canis ...
BAE58483  411 LAGKRLRKDSIAVIPTCQLHd-NPDTYGa--DAASFNPDRFlkqpgl-----------aqttfFPYGGGRHYCPGRYFVE 476 Aspergillus oryzae...
EED20043  358 IGGKKLRKGNRIMVSYRQLHl-NTDVWGp--TPELVQPDRFlrdksl----------ktnnsyRPWGGGSTLCPGRFFAK 424 Talaromyces stipit...
Feature 1                                                   #        
3B98_A    420 HAIKELVFTILTRFDvel----------cdKNATVPLVDpsrygFGILQPAGDLE 464 zebrafish
3SN5_A    435 HEIKQFLILMLSYFElel----------ieGQAKCPPLDqsragLGILPPLNDIE 479 human
EAL93738  448 RFVLLFVAMLLRRFDve------------lVTTRIPAAEegkpvLGIMSIKDGED 490 Aspergillus fumigatus Af293
CAP73657  423 REVKKAVALMMRRFDfevl-------aeggPGKWMPKGDdsrpgVGMMGIEKGGD 470 Podospora anserina DSM 980
EEA23201  481 FSATTFVAMLLQRFDve-----------lvGSPKLPAADegrpvLGIMSIKEGHD 524 Penicillium marneffei ATCC 18224
EEQ35349  469 QVVMVFAAMLVYQFDval----------dpPDQEFPKAEekipvLGIIGIKTDLS 513 Microsporum canis CBS 113480
EDN95674  468 KEILVCVALVLSRFEveldg-----akngsEAQPFPKVDttmlaLGVLPPKKGED 517 Sclerotinia sclerotiorum 1980 UF-70
EEQ35370  460 QEVLCFIGTALHQYDierl-------edpnDIPRFPRVDsakptFGIMAPLEGDD 507 Microsporum canis CBS 113480
BAE58483  477 MEIYGLVALMLNRYEmd-----------laWAAPFPRRDeslvtLGISRPVPGDD 520 Aspergillus oryzae RIB40
EED20043  425 KTIFTFISVLLVRYSaihikeetvgdnkggRKPAFPRADfskpiPGIVSPMMGDD 479 Talaromyces stipitatus ATCC 10500

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