Conserved Protein Domain Family
AknT-like

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cd11036: AknT-like 
AknT-like proteins
This family is composed of proteins similar to Streptomyces biosynthesis proteins including anthracycline biosynthesis proteins DnrQ and AknT, and macrolide antibiotic biosynthesis proteins TylM3 and DesVIII. Streptomyces peucetius DnrQ is involved in the biosynthesis of carminomycin and daunorubicin (daunomycin) while Streptomyces galilaeus AknT functions in the biosynthesis of aclacinomycin A. Streptomyces fradiae TylM3 is involved in the biosynthesis of tylosin derived from the polyketide lactone tylactone, and Streptomyces venezuelae functions in the biosynthesis of methymycin, neomethymycin, narbomycin, and pikromycin. These proteins are required for the glycosylation of specific substrates during the biosynthesis of specific anthracyclines and macrolide antibiotics. Although members of this family belong to the large cytochrome P450 (P450, CYP) superfamily and show significant similarity to cytochrome P450s, they lack heme-binding sites and are not functional cytochromes.
Statistics
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PSSM-Id: 410662
Aligned: 26 rows
Threshold Bit Score: 80.2269
Created: 28-Jan-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9L4U5    61 AGTPLWQSTT--GAWVTGrHGVAAEALADprlalrhadlpgpqrhvfsdawsnpqlchiipldraflhasdADHTRWARS 138 Streptomyces galilaeus
CAY49483  22 KNGLLFDAEL--GLWIASsANAVEAILGHpdcrvrplsepippaia--------rgaagvifgrlmrmnegPQHLCPRMA 91  Pseudomonas fluores...
ABA75210  22 AGGLTFHHGL--KLWVASsARAVCAVLAHpdcrvrpvqepvpkaiv--------dgmagkvfgllmrmndgEAQRCPRSA 91  Pseudomonas fluores...
ABB10889  25 GPPLAFDATL--GLWVASrAAAVTAVLGHpacrv--------------------------------rpldaPVPPALRGT 70  Burkholderia sp. 383
ACS86862  25 RETPVYFDRDl-KLWVVSdAGSTDAVLSSpvlqvrpvsqpvppglv--------gqpagdvfgqlvrmregEYQQQLKAV 95  Dickeya dadantii Ec...
ABE44723  30 EQRPLYFDEGl-KLWVASsHSVIDEAFHNvalrvrppaepvpqall--------gtaagevfaqlvrmtdgEFHAVHKPA 100 Polaromonas sp. JS666
EAP72584 201 AARPFHYDAAl-GWWIAAsAAAVDAVLGHtactvrpadepvprhla--------asptgvffgrlvrqidgPDHSARRAT 271 Ralstonia solanacea...
ABF10690  30 STRPFYFDPAl-KLWVAAsAAAVAEVLDHadgrvrpaaqpvppsla--------gsaagdlfgrlirmndgVAHAPLKAI 100 Ralstonia metallidu...
CAP42124  59 RERPLYYDPAl-GLWVASsPPLIHAVLAHraarv--------------------------------rpaaePVPRALGDD 105 Bordetella petrii
ABJ87544  13 APPEAARFDAaqQAWILSrYADVWSALREpnlwpvsgkr----------------------eivregresdGRLQQRAPM 70  Solibacter usitatus...
Q9L4U5   139 ASAVLgsaggapa-------------------egvrehaGRVHREAADRTGDSFDlm------------------aDYSR 181 Streptomyces galilaeus
CAY49483  92 IEPALasvgk-------------------------eslsEIVSRVVETLDDPVEDl-------------------dELMF 127 Pseudomonas fluores...
ABA75210  92 IEPPLglidr-------------------------eevgALVSARLITNDSDGLY---------------------KAMF 125 Pseudomonas fluores...
ABB10889  71 TAGALfgelvrmndgalrhdvpkqalrtafapidtvalrDRVTQLAARRLPTPGDaga----------------lnAWCM 134 Burkholderia sp. 383
ACS86862  96 IIRALstvds-------------------------ahvsQLARQLAQQALSDGEEi-------------------nRWMF 131 Dickeya dadantii Ec...
ABE44723 101 VEQAArrwsla-----------------------dvtraSEAAARDLFAAGPPQGkhgplggqrsvgakfrcltvnDLMG 157 Polaromonas sp. JS666
EAP72584 272 ILTALgrldv-------------------------ssvaAQAHRLAKMALPDATAldpa-------------ladaMHLR 313 Ralstonia solanacea...
ABF10690 101 VARQMaald---------------------------lsdARSRARALAAALPRVDhdda-------------heanRWMF 140 Ralstonia metallidu...
CAP42124 106 AAGLLfsrfvrmrddaahag----lkpllvdclqalpcgGAPCWPAAPHTLPGLD---------------------EFLF 160 Bordetella petrii
ABJ87544  71 LEAIAgg------------------------------rvEEWRPRLIGVTQRGLAslare-----------sellsDFLL 109 Solibacter usitatus...
Q9L4U5   182 PVATEAAAELLGvp---------aaQRERFAATCLALGValdaalcpqplavtrrlteAVEDVRALVGDLVEArrtqpgd 252 Streptomyces galilaeus
CAY49483 128 TLPVSVIAALIGlpsg------rlhEVAKLTRDFVACLSplsdeiq-----lgeahfgATRLNQLFSALLSDQedssrfm 196 Pseudomonas fluores...
ABA75210 126 RGPVCVVASLLGftpa------qarVISELTADFAACLSplsndlq------laaahrAAEQLRGYFIEMLADpnpflad 193 Pseudomonas fluores...
ABB10889 135 TVPVCAVADLLGfddt------qldDIAGLVVDFVAALSpl---------------sdAVALARASDAARQLLdrmtarv 193 Burkholderia sp. 383
ACS86862 132 SVPAAVVATLCGflprdv--pevvaLIAEFVLCIPAAAS-------------------PEHQQRASLAATSLLerffaqi 190 Dickeya dadantii Ec...
ABE44723 158 VLPVQAMARLLGlpdg------lldDSCRWVRQFVQGIApga-------------stqAVALAAGAAEALMDQgra---- 214 Polaromonas sp. JS666
EAP72584 314 IPLETLAHALLGddad------aaaCRQDIAAYLAALSPdap--------------agAIHRADTAVACLSARfatap-- 371 Ralstonia solanacea...
ABF10690 141 TLPVLAIADLLGlplerdtdghvstRVAGFVATFAAAMSplaspadve--agvaaaqwLTRLAQTAEDRETADigvlaal 218 Ralstonia metallidu...
CAP42124 161 AAPVYAMASRLGlaqp------aiaACARDVRLFRAALGpaatadq------laaghaAAARLQTAMMEHLHAqaddapl 228 Bordetella petrii
ABJ87544 110 PWGLSLAMMVTGae---------gsERARLGELSTRVFAatgve---------hkdaaLRADAAAATAELERIf------ 165 Solibacter usitatus...
Q9L4U5   253 dllsa---------vlhagssaasaGQDALAVGVLTAVVGVEVTAGLINNTLESLLTRp---vQWARLgenpelAAGAVE 320 Streptomyces galilaeus
CAY49483 197 shir-----------sacaanawseHDALIANLIGLLSQTCEATAGLIGNTLVALHRYp---dLTEGMqpepmlVADLVA 262 Pseudomonas fluores...
ABA75210 194 i-----------------rqrfvgnEEVLLANLIGLCSQTFEATAGLIGNALVALHRQp---eLRNAS------VDSLLA 247 Pseudomonas fluores...
ABB10889 194 aqshahdgtlvaavqqaarvsgwqaSGGLVANLVGLLSQTCEATAAWLGNTLVAWSGDas--aSAARVvpddaaLDAFVA 271 Burkholderia sp. 383
ACS86862 191 aqapqgal--ltellqcaseegwsqRAPLIANAIGFLSQTYDATASLAGNTLLTAQRYp---eLWLRRp-----ADAFID 260 Dickeya dadantii Ec...
ABE44723 215 ----------------------lglSTVQAANRIAFMQQSLDATAGLMGHTVLMLAQYpd--lALLADqsp-qaMRGFVA 269 Polaromonas sp. JS666
EAP72584 372 --------------------laahaDEALVANLAGLLVQTHDACAGLLGNAVVALARRp---gLAGHLhtrphaIDPFLY 428 Ralstonia solanacea...
ABF10690 219 aq---------------aggdskmdPATLTANAIGLMIQSCEATAGLIGNTLVYLGRS-----DWQGAd-----IGASVD 273 Ralstonia metallidu...
CAP42124 229 all------------rsraaqaefePAEVAANLAGLLFQSCEAGAGLVGNTLAALGRDpglcaAARRDaa---lCLHAAA 293 Bordetella petrii
ABJ87544 166 -------------------------EGGPVPMGEPAFVALSQTLPRLLANGWVALARNp---aEFARLranpelLPGAID 217 Solibacter usitatus...
Q9L4U5   321 EALRFAPPv-RLESRIAAEDltlgGQDLPAGAQVVVHVGAANrdpeaflaPDHFDLDRPagqgQLSLSGP--HTALFGAF 397 Streptomyces galilaeus
CAY49483 263 EVARYDSPv-QNTRRFVAKRciigDSVLEAGDTVLVLLASANrdpyanphPDSLLLKRTqrrtFSFGSGR--HECPGQQL 339 Pseudomonas fluores...
ABA75210 248 EVQRFDPSv-QNTRRFMANSceidGVRLEAGDVILVLLASANrdpalnenPDRFRVDRPnrrsFTFGSGR--HQCPGQTL 324 Pseudomonas fluores...
ABB10889 272 EVGRFDSPv-QNTRRFVASRttieGVTVEAGDAILVVLAAANrdpavhrdPHRFMPGRAa--gPNFGFGTgpHGCPGERI 348 Burkholderia sp. 383
ACS86862 261 ETARYTSPi-QNTRRFAAHEltllGQRIAPDDTILLLLAAANrdparfaqPDVFQPQRNtqayFSFSGGR--HRCPGAAV 337 Dickeya dadantii Ec...
ABE44723 270 EVERHQAPi-QNTRRFAADPvvlaGQSIEAGQGVVLVLASANrdgllnprPDQFDPQRGerrsMGFGAGA--HACPGAAI 346 Polaromonas sp. JS666
EAP72584 429 EVLRLDAPv-QNTRRFVSRDtalcGESLRAGDRILVLLAAANvdasanpdPLRFDLARAprrvWTFGAGA--HRCPGESL 505 Ralstonia solanacea...
ABF10690 274 RVARIDPPv-QNTRRFMAADamlcGQQVKEGDAVLVLLAAAAh------dPSSAAEERA----WTFGAGR--HGCPGDAL 340 Ralstonia metallidu...
CAP42124 294 HTARHDPPv-HNTRRYLDASmsldGQVLPAGATVLLVLAAAGaaap-gdaPWTFGAGRH----ACPGRTPa-LQAAGQAV 366 Bordetella petrii
ABJ87544 218 ELLRYAGIvrRVYRRSTAPVel-gGVTIAEGELAALMLASANrdpeqfpdPDRLDLGRVv--sSHVALGTgrNSCVGAML 294 Solibacter usitatus...
Q9L4U5   398 ARLQAETAVRTLRERRPv----lAPAGAVLRRm---rSPVLGAV 434 Streptomyces galilaeus
CAY49483 340 ALTIAAEAILAWLHRQPtss-vrPCQWGYLRSl---nGRIPQFN 379 Pseudomonas fluorescens SBW25
ABA75210 325 AMTIASATLTEILARNIdp---gRFTWHYRPSl---nGRVPMFS 362 Pseudomonas fluorescens PfO-1
ABB10889 349 ARAVTAGAFGAWLRAGGva---pHDGLAWDYRas-tnVRMPKFD 388 Burkholderia sp. 383
ACS86862 338 ARAITHGMVSALDAHMPd----wHQRLHKRRYlpsgnARIPEFS 377 Dickeya dadantii Ech703
ABE44723 347 AIEMVAACIQWMRATSQfdgcfgALAGFWPLAn----ARIPLFA 386 Polaromonas sp. JS666
EAP72584 506 AVAIARETVQHLLNLPGid--rwLAGVAMVRYqaspnARIPVFA 547 Ralstonia solanacearum UW551
ABF10690 341 ARVLATCTVDALLARDVhp---dRLAAGVRYRps-vnARIPSFS 380 Ralstonia metallidurans CH34
CAP42124 367 AFLLDAGLEPAALTQKLgy--wpLPNARVPRF-----ARHGVQA 403 Bordetella petrii
ABJ87544 295 IRMAASVATEAVAERFVef--gpCRVGEWRTGs----GFCFPAS 332 Solibacter usitatus Ellin6076
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