1T2B,1T2B,4FB2,4L6G,3BDZ,4L77


Conserved Protein Domain Family
P450cin-like
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cd11034: P450cin-like 
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P450cin and similar cytochrome P450s
This group is composed of Citrobacter braakii cytochrome P450cin (P450cin, also called CYP176A1) and similar proteins. P450cin is a bacterial P450 enzyme that catalyzes the enantiospecific hydroxylation of 1,8-cineole to (1R)-6beta-hydroxycineole; its natural reduction-oxidation partner is cindoxin. This family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Links
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Statistics
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PSSM-Id: 410660
Aligned: 15 rows
Threshold Bit Score: 465.657
Created: 28-Jan-2010
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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heme bindingchemical
Conserved site includes 28 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                  #     #                            
1T2B_B     31 AETTPIGWSEay------gGHWVVAg----YKEIQAVIQNTKAFSNk---GVTFp--------rYETGe-------fELM 82  Citrobacter braakii
3BDZ_A     31 AETTPIGWSEay------gGHWVVAg----YKEIQAVIQNTKAFSNk---GVTFp--------rYETGe-------fELM 82  Citrobacter braakii
4L77_A     32 AETTPIGWSEay------gGHWVVAg----YKEIQAVIQNTKAFSNk---GVTFp--------rYETGe-------fELM 83  Citrobacter braakii
BAH31514   38 RNECPVAPSNel------gGFQLLSr----YEDVWAATLDTETYSSa--eGTTVp---------KHPV---------RMP 87  Rhodococcus erythr...
ABP44248   33 RGNSPFARTDnpflsatpsGAWVAVr----YAECVQILQDWEHFSSs---PTPEg---------AEQLa--------GDL 88  Mycobacterium gilv...
CBG68602   35 RTIGAIVPTDqld----fsGRFKETlqvigYAECHQLLKDWRRVSNd--pRKAFdnlse-ierrSDLPvd------dSAT 101 Streptomyces scabi...
CAJ96525   34 SSGCPVAHSEkw------gGSWLPTt----YDDIHHVAQNPAVFSS----RAAEiag-----evPPQGsg------lVLP 88  Ralstonia eutropha...
ABQ67388   26 RAHCPVLRSDah------gGFAILTr----YADNRAALRNHDTFASg---RIRAgdrlgggvaiPPNGl--------RIG 84  Sphingomonas witti...
ABQ68324   34 REKCPVFASEah------gGYWVAAs----YEHATNISRDWETFSSr---KVWDpea-----gkLEGGsvippfagpPFV 95  Sphingomonas witti...
ABK68990   36 ESGCPVAHSDhy------eGFWALVd----YASVFEAARDDDLFNSfpsvGVPA----------SELPl--------PIL 87  Mycobacterium aviu...

Feature 1     ##      #   #      #                                                            
1T2B_B     83 MAGQDDPVHKKYRQLVAKPFSPEATDlFTEQLRQSTNDLIDARIELGEGDAatWLANEIPARLTAILLGLpp---eDGDT 159 Citrobacter braakii
3BDZ_A     83 MAGQDDPVHKKYRQLVAKPFSPEATDlFTEQLRQSTNDLIDARIELGEGDAatWLANEIPARLTAILLGLpp---eDGDT 159 Citrobacter braakii
4L77_A     84 MAGQDDPVHKKYRQLVAKPFSPEATDlFTEQLRQSTNDLIDARIELGEGDAatWLANEIPARLTAILLGLpp---eDGDT 160 Citrobacter braakii
BAH31514   88 PEDTDEPEHRLYRKIMDPLFTPKTVKtMESWVREIVVELFDSIADPNRFDFvqEFSSQLPRRVILRIIGVpd---eDLPV 164 Rhodococcus erythr...
ABP44248   89 VITLDPPRQQKFRKVLNPYFSPARMKaLRHEIAAETDDLIDVFIESGSGDLaeVAWRQPGIVFFKYLLGMpvddvpLCVE 168 Mycobacterium gilv...
CBG68602  102 PISTDPPVQKELRKVLSPSFTPERMVaLEPKVRAVANRLIDEFIEEGKGDLadFSWKLPSEILFAEFLGFpa--elLGEA 179 Streptomyces scabi...
CAJ96525   89 PLTSDPPDHKIHRDLLEPYFTPARVAaIEPYAQSLARDLARRVAVKGEADLgeDYSKPFVLSLLTRFLDVpd---dRQER 165 Ralstonia eutropha...
ABQ67388   85 MIEMDGAEARALRALLQPWFTIAAVEaAAPRMAQLSAWLVDRIIARGACDVveDLAKPMPSLLILDILGLp----lDRWR 160 Sphingomonas witti...
ABQ68324   96 PVETDPPEWKLYRHLLNPFFGPKAVEtYRTRARQVMRALVDRVIETGACDIvnDLANPLPALSTLDILGIp----yDQSN 171 Sphingomonas witti...
ABK68990   88 PIESDPPETQQLREVTLKRFSPGSAErFRDAAIEMTNEAIDAFIERGECDLvtELTTPLPARLILRLLKFde---sRHMD 164 Mycobacterium aviu...

Feature 1                                                                               ##  ##
1T2B_B    160 YRRWVWAITHve------npEEGAEIFAELVAHARTLIAERRTNPg-NDIMSRVIMSKIDGeslSEDDLIGFFTILLLGG 232 Citrobacter braakii
3BDZ_A    160 YRRWVWAITHve------npEEGAEIFAELVAHARTLIAERRTNPg-NDIMSRVIMSKIDGeslSEDDLIGFFTILLLGG 232 Citrobacter braakii
4L77_A    161 YRRWVWAITHve------npEEGAEIFAELVAHARTLIAERRTNPg-NDIMSRVIMSKIDGeslSEDDLIGFFTILLLGG 233 Citrobacter braakii
BAH31514  165 LIDAMIALNGayd-----daERGAAAGATLYGYFAQKLVERREQPrrDDLISALLEGDFGGeplSDLDMQHMLILTILGG 239 Rhodococcus erythr...
ABP44248  169 LTDTALNGATe---------EARMGAWGGLYQHLHDAVTARTAEPprDDMIDVLLSAEIDGeklAFGDVVSNAMLLVQAG 239 Mycobacterium gilv...
CBG68602  180 LAAQGASLLAsd-------aAERDQSAARVFELIADVLKERVGQPprDDIIDGLLNSEIGGrplTVGERMANATLLVAAS 252 Streptomyces scabi...
CAJ96525  166 FMDWAIRVLKygp----fdqELRKAAFDEAFADLEQLLKEREQDPg-EDLVSHIALATIDGkpiSRKHRIGSLLLAVLAG 240 Ralstonia eutropha...
ABQ67388  161 DYGRVLHEAVak-------sSGSIDGLRWLASDLRASVERREVHP--EGLIAAMIAAEVDGrplGDALVCELAMMLLFGG 231 Sphingomonas witti...
ABQ68324  172 WRRFSDPFHKlayargtaefPQCLADLDWIRGQLAEQVERDRANPr-EGLFSSLCNGEVAGkafSVPEIVGLGMMVLVGG 250 Sphingomonas witti...
ABK68990  165 WVHWVHSTVHdra----hdpERAGAAGMEMFGEIVKHMEERRAEGlgDDLFSDILRGTLNGkplDDGQITMYTVLMMLGG 240 Mycobacterium aviu...

Feature 1       ##  #                                      # # # #                      #     
1T2B_B    233 IDNTARFLSSVFWRLAWDIeLRRRLIah-peLIPNAVDELLRFYGP-AMVGRLVTQEVTVGDITMKPGQTAMLWFPIASR 310 Citrobacter braakii
3BDZ_A    233 IDATARFLSSVFWRLAWDIeLRRRLIah-peLIPNAVDELLRFYGP-AMVGRLVTQEVTVGDITMKPGQTAMLWFPIASR 310 Citrobacter braakii
4L77_A    234 IDATARFLSSVFWRLAWDIeLRRRLIah-peLIPNAVDELLRFYGP-AMVGRLVTQEVTVGDITMKPGQTAMLWFPIASR 311 Citrobacter braakii
BAH31514  240 TDTSSGAMGGMMLWLADHPeDFAKLRee-pdLIRTAIDEFLRYVSPvAYMARTATKDVEVQGCPIQHGEKVLLGFGSANR 318 Rhodococcus erythr...
ABP44248  240 LETTASAMSFAYHYLATHPaERDRLIae-pdLLARAVEEFIRFAGSiHGIPRTVAKEVELSGCTFSPGESVIVNYASANR 318 Mycobacterium gilv...
CBG68602  253 LETTSNALSAAYYWLAHHPaERSRLVad-psLLPAAVEEFVRYSGSvHGLPRYITADVEICGYGFKRGDAVIVNYAAANR 331 Streptomyces scabi...
CAJ96525  241 ADTTWNALNASLNHLADHPaDRATLInepglLRTTAVEELLRFYAP-LSIARVTTEEVELKGRCIGAGERVILAYPAANR 319 Ralstonia eutropha...
ABQ67388  232 TDTTIAAIGHALRHLTEHPaDRAALVar-paLIPAAVEEILRLYSPsTGVARTVTAPVEIGGERFEPGQRVLCAINSANR 310 Sphingomonas witti...
ABQ68324  251 VGTTNALFSNSCVWLSKHPeVRRKLIdn-pdMLPIAREEFVRFYSPvHSAARLVTREVVVNGQRLEPGEQIMVAFSSANH 329 Sphingomonas witti...
ABK68990  241 MDTTSGFTGNVLLRLCQDLeLRQQFIdd-psLVKKGTDELLRLYTPtLGLARTVSRDAEFHGQRLCKGDRAILMWAAANR 319 Mycobacterium aviu...

Feature 1                           ###  ## ###   #                                           
1T2B_B    311 DRsafdSPDNIVIERTp-NRHLSLGHGIHRCLGAHLIRVEARVAITEFLKRIPEFSLdPNKECEWLMGq--VAGMLHVPI 387 Citrobacter braakii
3BDZ_A    311 DRsafdSPDNIVIERTp-NRHLSLGHGIHRCLGAHLIRVEARVAITEFLKRIPEFSLdPNKECEWLMGq--VAGMLHVPI 387 Citrobacter braakii
4L77_A    312 DRsafdSPDNIVIERTp-NRHLSLGHGIHRCLGAHLIRVEARVAITEFLKRIPEFSLdPNKECEWLMGq--VAGMLHVPI 388 Citrobacter braakii
BAH31514  319 DSekfdRADEVLLDRHp-NPHMAFGGGPHRCLGANLVKLEMKIVLEEVISRFRSFEV-EDYTKLYYQRg-qARNLECLPL 395 Rhodococcus erythr...
ABP44248  319 DEeqfpEADRCILDRRe-NRHLGFGAGVHRCLGSNLARLEFQVGLERVLTRMPDFTLtAGAEAKFHGNs-vTRGFRSVPV 396 Mycobacterium gilv...
CBG68602  332 DEnefaDAGKCIIDREp-NRHLGFGFGTHRCLGAPLARLELRVGFSEVLRRLPDYRIaNEDTCEFSGSs-fTRGYQALPV 409 Streptomyces scabi...
CAJ96525  320 DPavfeNPDEVQLDRKr-NRHLTFGVGVHRCLGSHLARMEMRVAIEEWLKAIPNFER-ISGAVKWSAGn--ARGPENVRI 395 Ralstonia eutropha...
ABQ67388  311 DEemfaDAERFDLDRPk-RPHLAFGWGVHACLGQNLARADLRILLGELLARMPDFAV-DVAASERYASiplVNGHARMPM 388 Sphingomonas witti...
ABQ68324  330 DEtvfeNAGEIDVERFp-NPHVGFGSGIHRCLGSFLARMFFETMFAEVMARMPDFLVdEERAVRYPDIs-tKNGWITIPA 407 Sphingomonas witti...
ABK68990  320 DPamfeDPDTLDLSRPnaKKQMAFGVGMHRCLGSHYAKMMFDVMLTQVLKRLPDFEL-AGEPELFEDAg-eVYAVRKLPV 397 Mycobacterium aviu...

Feature 1       
1T2B_B    388 IF 389 Citrobacter braakii
3BDZ_A    388 IF 389 Citrobacter braakii
4L77_A    389 IF 390 Citrobacter braakii
BAH31514  396 VV 397 Rhodococcus erythropolis PR4
ABP44248  397 TF 398 Mycobacterium gilvum PYR-GCK
CBG68602  410 AF 411 Streptomyces scabiei 87.22
CAJ96525  396 RV 397 Ralstonia eutropha H16
ABQ67388  389 RF 390 Sphingomonas wittichii RW1
ABQ68324  408 TF 409 Sphingomonas wittichii RW1
ABK68990  398 KF 399 Mycobacterium avium 104

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