3RUK,4Y8W


Conserved Protein Domain Family
CYP17A1-like

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cd11027: CYP17A1-like 
Click on image for an interactive view with Cn3D
cytochrome P450 family 17, subfamily A, polypeptide 1, and similar cytochrome P450s
This subfamily contains cytochrome P450 17A1 (CYP17A1 or Cyp17a1), cytochrome P450 21 (CYP21 or Cyp21) and similar proteins. CYP17A1, also called cytochrome P450c17, steroid 17-alpha-hydroxylase (EC 1.14.14.19)/17,20 lyase (EC 1.14.14.32), or 17-alpha-hydroxyprogesterone aldolase, catalyzes the conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione; it catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. This subfamily also contains CYP21, also called steroid 21-hydroxylase (EC 1.14.14.16) or cytochrome P-450c21 or CYP21A2, catalyzes the 21-hydroxylation of steroids and is required for the adrenal synthesis of mineralocorticoids and glucocorticoids. The CYP17A1-like subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410653
Aligned: 30 rows
Threshold Bit Score: 550.66
Created: 18-Sep-2010
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
heme bindingchemical
Conserved site includes 22 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                             #                  #       #   #           
3RUK_A        42 YGPIYSVRmgtkTTVIVGhHQLAKEVLIKKg-kDFSGRPQMATLDIAsnn--rkGIAFADSGAHWQLHRRLAMATFalfk 118 human
XP_019639175  60 YGDVFSLRrgmtDVVVLNsEAAVREALVEKs-vEFAGRPHAQSLDIRten--rrNMAFTDYGPAWKQHRKIVKSALrera 136 Belcher's lancelet
PIK40958      73 YGDIFSIRvgqrWAVVLNgAATIKEALLKKg-vEFANRPTSVTIDLFteg--gqDIVFGQYSPSWKLHRKLAFSAFrkla 149 Japanese sea cu...
XP_002604243  53 YGDVFSLKlgmtDVVVLNsLDAVKEAFMKKg-aDFAGRPKMLSMDISseg--gkDIVFTDYNPTWKLHRKLFHGAIrgya 129 Florida lancelet
XP_783645     73 YGDIFGFKagerWIVVLNrQALIKEAVLKQs-vGFADRPDFLSLDIFsdg--fkDIAFSPYSETWKLHRKLAHSALrhfa 149 purple sea urchin
EDV22934      62 YGDVFTVFigtrPCLIVNgVNKVKEALLKNs-vTFGGRPNLMLFKFFeipngpvGISATDYTPTLRLHRKVTHTAIrnyt 140 Trichoplax adha...
EDO32562      84 YGQVFSMYlgsrLVVVLN-GMALQEALTGKlsrVFAGRPKLYTMERCrng--gdGLINAPYCRKWKLMRKTAITAIhkyi 160 starlet sea ane...
XP_019642124  64 YGDVFSLKlgmrDVVVLNsLDVIREAFVKKg-aDFAGRTHTMTGDLVseg--rkDIVMGDFTATWKLQRKLFHGAVraya 140 Belcher's lancelet
XP_029188210  71 YGDVFSLMlgnrLVVVVNgVNAIHETIVKQs-iAFAGRPKLHTFQIAnpq--gnSLSLSDYSHQYRLSRKISVSAIhnfv 147 Acropora millepora
PFX23500     125 YGDVFSLMlgnrLVVVLNgFNVIQETIIKKp-tVFAGRPRLYTFDLAnpd--gnSLTVGDYTPQWRLSRKMSVAAVhnfa 201 Stylophora pist...
Feature 1                                                                                        
3RUK_A       119 ----dgdqKLEKIICQEISTLCDMLATHngqsidISFPVFVAVTNVISLICFNtsyk---ngdPELNVIQNYNEGIIDNL 191 human
XP_019639175 137 -----sgrTLETEAHEALEDIIGELASVegqavdLNDHIFKLVYNVVCPVAFGvrfe---qedEDFQNLKKFSEDFFKQD 208 Belcher's lancelet
PIK40958     150 t---gdnkRFEKLVYSIIPALTANLDSKgsepfdTRRVLASSIYNILASLCFGkqye---fddPELTRLMYLSKEGNDIA 223 Japanese sea cu...
XP_002604243 130 -----sgqNLQSKVHESLKDTIAEFTKMegqgvnLDDYLYQLVYNVICSAAFGvryn---mddENFKTLMKVSKDAAERF 201 Florida lancelet
XP_783645    150 -----tgkPLQDLISSVYPKVEKKLAMTegqpidPKVLITLLMYNVLAQMCFGrsye---ledPNVAQWMNTNDEINEHL 221 purple sea urchin
EDV22934     141 qasgsdaaKFEQLVRGEINKLIKVIEKHeskpfdVLPDLLNSVTFLIFTVCFGpdsfekyidrKSLEKLSAALTVFDEYI 220 Trichoplax adha...
EDO32562     161 ----atqdVLESILGKVAHGLVQRLDACaetphnVMPELKFATASVILGILFGenh-----daSHVESILGTSDDFRKCV 231 starlet sea ane...
XP_019642124 141 -----tghTLEEKVQGALNEVIAEFSSMvgrpvdVEDHIFKLVLNVVCSASFGhryk---medKDFQFLLNLSKEFFEIG 212 Belcher's lancelet
XP_029188210 148 ----knadALEEKLLHESQRLIHHFQKMkgkpvdALLTLKCATANIILNALFGlers---yddVDLLNMLNLSDNFRKSV 220 Acropora millepora
PFX23500     202 ----kdtsSLEKKLFQESERLICCLKQQkgkafdVRITLKFATANIILNALFGinrs---yddQDLRRILELADNYREAV 274 Stylophora pist...
Feature 1                                                                                        
3RUK_A       192 Skdslvdl----vpwlkifPNKTLEKLKSHVKIRNDLLNKILENYkekfrsdsiTNMLDTLMQAKmnsdngna------- 260 human
XP_019639175 209 Aplgdiy------pslgflPNQAKTDLQKLMDVLLGYFRRQVDRHrkefnpndlRDVTDHMIKAQkeaeerg-------- 274 Belcher's lancelet
PIK40958     224 Gsgllady----ipifkyvPTPGQTKLKAIFKDFFSLVNKEVDEHrekydggepKDFIEMLFQSRqeikdeg-------- 291 Japanese sea cu...
XP_002604243 202 Gqgfladv----ypllrflPSPTVTACRKMMDQILGIMQCHLEQHketfdpsnrRDITDHMIKAQkdaeeeg-------- 269 Florida lancelet
XP_783645    222 Glglaadf----fswakylPTNGPWMLKELQERLWGFLRLQVDETrehydpeniNNVYSLLLKAQedarke--------- 288 purple sea urchin
EDV22934     221 SmnnifdtfpflyhllmkiPSKTNRELEALTNDLLSMLEKELETHketydpdtvRDILDAMIKAKreaedee-------- 292 Trichoplax adha...
EDO32562     232 Gcglavdf----mpwmenfPIPKVNRMVKLTSDMNAVLKNLYEENktsy-sgriRNLADAVIKVSeehsqidd------- 299 starlet sea ane...
XP_019642124 213 Aqgmladi----ypslgflPTPTKTAMAKGMGEFFEYFKRELDRHvqtfdpdhlRDITDHFIQLQreaedeg-------- 280 Belcher's lancelet
XP_029188210 221 Tgsshvdf----lpllkylPNKALSNLTFMMRTFLGNITEMFEQNrdtyvgghvRNIADSFINVVeketekekedrq-pg 295 Acropora millepora
PFX23500     275 Hgsshidf----lpflkhlPNRALTKLVLALKEVSAATKKMFLKNketytegqvRNIADGFINVLeketmkeaengqnse 350 Stylophora pist...
Feature 1                                ##  #   #                                               
3RUK_A       261 -gpdqdselLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQnvgfsrtptisdrnrLLLLEATI 339 human
XP_019639175 275 ---dldtsaLTDTHLRQIVADVFLGGTETTTQILRWAVLFLAAHPEIQEKVAAELDSvvgrdrlpelsdreaTPYTEATV 351 Belcher's lancelet
PIK40958     292 ---kedmslITEAHIRQTVVDVFGAGTDTSIFTLQWCAGLMVQYPEVQAKVAEEVDRvvgrdrlpslddreeLVYTTATL 368 Japanese sea cu...
XP_002604243 270 ---iqdinsLTDTHLRQTISDIFFGGTFSSIFSLRWALLYLAVHPEIQEKVAAELDSvvgrdrlpelsdreaTPYMEATI 346 Florida lancelet
XP_783645    289 ---genvdkLTDTHIFQTIADIFTAGILTTVETLYWAMALLVTYPEIQAKIRVEIDDvigrdrlptindrgkLPYTEASL 365 purple sea urchin
EDV22934     293 --rddkasmLDDYSLIGTIGDLFFAGMQTTSYTVQWYLLFMITHPQIQKKVHDELDQivgrnnypaienrssLKFLDATI 370 Trichoplax adha...
EDO32562     300 --dsdpkgeMADLDVVQTIVDLVGAGFDTSSLTLYWAIAYFVKYPQVQRRIHHEIDTvigrdriptlddvkhLPYTHACL 377 starlet sea ane...
XP_019642124 281 ---dedirsLTDVHFRQTVIDIFGAALDTTVQTMRWSVLLLAAHPEVQQKLSAELDSvveqdrqpmlsdrtaLPYMDATI 357 Belcher's lancelet
XP_029188210 296 edtlcmapvLSDEQIVPVLTDLFGAGFDTSSVTLYWALAYLMAFPEIQSQLHEELDRvigrqrlptmsdltsLPLLQATV 375 Acropora millepora
PFX23500     351 ntqvemsplLNDEQIVQVLTELFGASLDTSSITVYWGLAYLIKHPEIQCQLQDELDNvigrdrlptltdipsLPLLQATV 430 Stylophora pist...
Feature 1           #    ##  ## #                                                             ## 
3RUK_A       340 REVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHhNEKEWhQPDQFMPERFlnpagtq-lispsvsYLPFG 418 human
XP_019639175 352 NEVLKMGLIDPLSLPHATTADTTLQGYHIPKGTEVLPNLWALHhDPDTWgDPHTFRPERFldetgnl--mpkpfaLMPFS 429 Belcher's lancelet
PIK40958     369 YEVMRYSTLVPLAVPHATSADVELGGYTIPKDTWVLVNIYSMHyDEKLWdDPKKFTPEHFldesgkv--rlhpegYMPFS 446 Japanese sea cu...
XP_002604243 347 HEVMRMASMDPLSLPHATTVDTTLRGYQIPKGTMVMPNLWALHhDPDTWgDPDVFRPERFldengk---pvkpaaLMPFS 423 Florida lancelet
XP_783645    366 YEVLRYSSIVPNALPHATTRDTEFGGYHIPKGTTVIINTYSMHyDPQEWdQPDKFLPEHFmdgsgtv--rdhppsFLPFG 443 purple sea urchin
EDV22934     371 SETLRLSSIVPLSLPHAPLKDIEIFGQKIPKGTAVWVNLWSVHhDEALWpNAKQFQPQRFldkngd---likspnLIPFS 447 Trichoplax adha...
EDO32562     378 YELLRVTCLAPTAVPHSTLEEVDFRGYTIPKDTVIFANIWSLLrNEEYWqNPDVFDPMRFldeegrllnpnswptFLPFG 457 starlet sea ane...
XP_019642124 358 NEVLRFGIVVPIAIPHATTVDTTLRGYEIPEGTWIMPNLWNVVrDPEIWgDPDSFRPERFldddgkv--lpkpsaLLPFS 435 Belcher's lancelet
XP_029188210 376 LELLRISSIAPLSVPRSTTADTTIRDFKIPKDTLVFVNLWSVHrDPETWkDPDVFCPSRFldsqgqlidpkffagFLPFS 455 Acropora millepora
PFX23500     431 YELLRVTSVAPLAIPHSTTTETTIRDFTIPKDTMVFINLWSLHrDPAIWkDPDVFNPRRFlngagelidpktfggFLPFS 510 Stylophora pist...
Feature 1           # ###  ##                                                    
3RUK_A       419 AGPRSCIGEILARQELFLIMAWLLQRFDLevp---ddgQLPSLEGi------pKVVFLIDSFKV 473 human
XP_019639175 430 VGRRACPGEKMGMADTYLLLAGLVQNFHFsfp---egeTPPDLSSv------kREVEKSANLHP 484 Belcher's lancelet
PIK40958     447 TGRRVCIGESVAKAELFLLFAWLFQHYKFskpi--gqeEKDFSEGd------pQAALNMLKDIE 502 Japanese sea cucumber
XP_002604243 424 AGRRACPGETLGKANNFLLLGGLVQNFRFsis---kgeGPPDLTPdek---ggGASCIPSPYKV 481 Florida lancelet
XP_783645    444 AGRRGCLGEAVAKADLFLIFTWFMQNYTFsk------aPGKESEDilkmipqtASGRLLLSYEI 501 purple sea urchin
EDV22934     448 VGTRTCIGESLARYELFMYISHLMNHFEFkma---esqESYDLQPr------pGLVHGCKSYKL 502 Trichoplax adhaerens
EDO32562     458 AGIRKCTGRELAIAELMFFITAIMQKFRFseegltadhPPIDLTGe------aGLTLKPADYHV 515 starlet sea anemone
XP_019642124 436 AGRRACPGEPMARADIFLLLGGLVQKFKFslp---egeVPPDLTPdpk---gaGLFSIPRPYKV 493 Belcher's lancelet
XP_029188210 456 AGRRKCPGEPLVMKTISVFLATLLHRFRFtq-----dgLPAEYQGinlq-gqnGLTLMPETFYT 513 Acropora millepora
PFX23500     511 GGRRRCPGESLAMKTLPVFLAALLHSFRFsq-----dgLPAEYQGinle-ghfGLTLMPEKFFT 568 Stylophora pistillata

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