Conserved Protein Domain Family
CuRO_2_ceruloplasmin_like_2
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cd11023: CuRO_2_ceruloplasmin_like_2 
cupredoxin domain of ceruloplasmin homologs
Uncharacterized subfamily of ceruloplasmin homologous proteins. Ceruloplasmin (ferroxidase) is a multicopper oxidase essential for normal iron homeostasis. Ceruloplasmin also functions in copper transport, amine oxidase and as an antioxidant preventing free radicals in serum. The protein has 6 cupredoxin domains and exhibits internal sequence homology that appears to have evolved from the triplication of a sequence unit composed of two tandem cupredoxin domains. This model represents the first domain of the triplicated units.
Links
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Statistics
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PSSM-Id: 259909
Aligned: 3 rows
Threshold Bit Score: 207.462
Created: 4-Jun-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Type 1 (T1) Cu
Feature 1: Type 1 (T1) Cu binding site, 4 residue positions
Conserved feature residue pattern:H C H MClick to see conserved feature residue pattern help
Evidence:
  • Comment:Type 1 (T1) copper sites are characterized by their conserved H...C...H...M copper ligands.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                   #  
NP_841583  214 DQEFIALYMIFNEENDEEsg--------------------lKHAINGrifgNLSGFETRRGQRVRWHLVALGNEVDNHTV 273  Nitrosomonas eur...
YP_344595  251 DREFITAFFIFDKLEGEEag--------------------lMHGINGyffgNLRGLVAKQGERVRWHVLGMGNEVDLHTP 310  Nitrosococcus oc...
AAL78162  1002 WQVVDENSSPFLDLNVEAaqlnvtkfendavlsadfdegnrMHSINGyvycNQPLVTIAKGKKLRWVLVAYGTEGDFHSP 1081 Chlamydomonas re...

Feature 1                                                  #    #    #      
NP_841583  274 HWHGQTVLDHg----RRTDVVEIMPaSMTSVDMVPRsPGNWLFHCHvNDHMIAGMATRWLV 330  Nitrosomonas europaea ATCC 19718
YP_344595  311 HWHGETVSVGaphvaRRTDVLELLPaSMITADMEADnSGEWLYHCHvADHIEGGMSTTFQI 371  Nitrosococcus oceani ATCC 19707
AAL78162  1082 QFTGQSLEADk---sGYSTLASLMPsIARVADMTAAdVGTWLLYCDvHDHYMAGMMSQFAV 1139 Chlamydomonas reinhardtii

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