2J5W


Conserved Protein Domain Family
CuRO_4_ceruloplasmin
?
cd11022: CuRO_4_ceruloplasmin 
Click on image for an interactive view with Cn3D
The fourth cupredoxin domain of Ceruloplasmin
Ceruloplasmin is a multicopper oxidase essential for normal iron homeostasis and copper transport in blood. It also functions in amine oxidation and as an antioxidant preventing free radicals in serum. The protein has 6 cupredoxin domains with six copper centers; three mononuclear sites in domain 2, 4 and 6 and three in the form of trinuclear clusters at the interface of domains 1 and 6. Ceruloplasmin exhibits internal sequence homology that appears to have evolved from the triplication of a sequence unit composed of two tandem cupredoxin domains. This model represents the fourth cupredoxin domain of ceruloplasmin.
Links
?
Statistics
?
PSSM-Id: 259908
Aligned: 7 rows
Threshold Bit Score: 273.204
Created: 4-Jun-2012
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: Type 1 (T1) Cu binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:H C H MClick to see conserved feature residue pattern help
Evidence:
  • Structure:2J5W; Human ceruloplasmin binds copper at the T1 site of cupredoxin domain 4.
  • Comment:Type 1 (T1) copper sites are characterized by their conserved H...C...H...M copper ligands.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
2J5W_A        575 DKEFYLFPTVFDENESLlLEDNIRMFTtapdqvdkededFQESNKMHSMNGFMygNQPGLTMCKgDSVVWYLFSAGNEAD 654  human
Q6MZM0        576 DKEFYLLFTVFDENLSRyFDENIQKFIwhpfsidkedkeFVKSNRMHAVNGYMygNQPGLNMCKrDRVSWHLIGLGTDTD 655  human
Q9BQS7        575 DKEFFLLFTVLDENKSWySNANQAAAMldfrllsediegFQDSNRMHAINGFLfsNLPRLDMCKgDTVAWHLLGLGTETD 654  human
CAG00485      497 DKEFFLLFSVMDENESPyLKENTDQFApnasv---ldelFMESNMMHAINGRMysNLKGLEMCAgDNVMWYTFGLGTEVD 573  Tetraodon nig...
AAK55535      127 DKEFHLLATVFDENLSWyLDDNINRYAkqpksvnkedadFQESNKMHSLNGYMygNLKGLNMCKgDKVSWHLSGLGSETD 206  zebrafish
XP_001235149  571 TREFFLLATVFDENLSWyLDDNILMFTakpneidkdnedFQESNKMHSINGYMygNQPGLEMCKgDVISWHLMGLGSEVD 650  chicken
XP_002937375  572 AHNYFLLPTVFDENESWyLDENIQQFTgtpanvnkedpdFQESNMMHSINGYMygNQPGLDMCAgDTVLWHLMGLGNEVD 651  western clawe...

Feature 1          #                                          #    #    #         
2J5W_A        655 VHGIYFSGNTYLWRGERRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQC 718  human
Q6MZM0        656 MHGIVFQGNTIHLRGTHRDSLALFPHMATTAFMQPDHAGIFRVFCATMPHLSRGMGQIYEVSSC 719  human
Q9BQS7        655 VHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQC 718  human
CAG00485      574 IHGVHFEGNTFKKQGTTRDTLNLFPHTTSAVSMQPKVPGVYEVNCQVTDHYSAGMRQQYTVNRC 637  Tetraodon nigroviridis
AAK55535      207 IHGLYFEGNRFLYKETRRDTINVFPHISHTVIMEPDSMGQFEVNCKTTDHYHGGMRANYTVEKC 270  zebrafish
XP_001235149  651 VHGIYFSQNTFVTKGARKDTANLFPHTFVTAIMKPDSEGIFEVSCLTTDHYRGGMKQKYKVKPC 714  chicken
XP_002937375  652 MHGIHFSGNTIVTHYTRADTASLFPHISYSVMMNPDNEGVFNVECMTTDHYTAGMRQHYRVKSC 715  western clawed frog

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap