1KCW,2J5W


Conserved Protein Domain Family
CuRO_2_ceruloplasmin
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cd11021: CuRO_2_ceruloplasmin 
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The second cupredoxin domain of Ceruloplasmin
Ceruloplasmin is a multicopper oxidase essential for normal iron homeostasis and copper transport in blood. It also functions in amine oxidation and as an antioxidant preventing free radicals in serum. The protein has 6 cupredoxin domains with six copper centers; three mononuclear sites in domain 2, 4 and 6 and three in the form of trinuclear clusters at the interface of domains 1 and 6. Ceruloplasmin exhibits internal sequence homology that appears to have evolved from the triplication of a sequence unit composed of two tandem cupredoxin domains. This model represents the second cupredoxin domain of ceruloplasmin.
Links
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Statistics
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PSSM-Id: 259907
Aligned: 8 rows
Threshold Bit Score: 277.815
Created: 4-Jun-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: Type 1 (T1) Cu binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:H C H XClick to see conserved feature residue pattern help
Evidence:
  • Structure:2J5W; Human ceruloplasmin binds copper at the T1 site of cupredoxin domain 2.
  • Comment:Type 1 (T1) copper sites are characterized by their conserved H...C...H...M copper ligands.
  • Comment:Some members bind copper at the T1 site with three amino acid residues (HCH), instead of four (HCHM).
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
1KCW_A        195 DREFVVMFSVVDENFSWYLEDNIktYCSEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGLSMCAeDRVKWYLFGMGNEVD 274  human
2J5W_A        214 DREFVVMFSVVDENFSWYLEDNIktYCSEPEKVDKDNEDFQQSNRMYSVNGYTFGSLSGLSMCAeDRVKWYLFGMGNEVD 293  human
AAH64000      217 DYLYTLMFTVSDENLSWYLDENIktYCSAPAKVNKDDEAFQESNKMHSINGYVYGNLPDLSMCIgNKIHWHLFGMGNEVD 296  zebrafish
CAG00485      149 VQEVVLMFNVVDENLSWYQEENIq-SCYNPKEVDLDDPDFHDSNLMHAINGYTFGTLPGISLCQgQAVAWHLFGMGNEMD 227  Tetraodon nig...
Q9BQS7        223 DHDFFLLFSVVDENLSWHLNENIatYCSDPASVDKEDETFQESNRMHAINGFVFGNLPELNMCAqKRVAWHLFGMGNEID 302  human
NP_001092142  223 DREFVIMFTLVDENQSWYLNENIkhFCTNPDSVDKKDAVFQRSNKMHALNGYLFGNFPEPDMCVgESVSWHLFGMGNEID 302  human
XP_001235149  216 DAEFILMFSVMDENLSWYLDDNIrmYCSEPSKVDKDDEDFQESNKMHSINGYMYGYLPDLTMCVeDKVKWHLFGMGNEAD 295  chicken
XP_002937375  214 YKEFVLMFSVIDENLSWYLDENIntFCTEPSSVDKNDTDFQESNKMHSINGYMFGNLPGLSMCEgEHIHWYLFGMGNEAD 293  western clawe...

Feature 1          #                                          #    #    #      
1KCW_A        275 VHAAFFHGQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQV 335  human
2J5W_A        294 VHAAFFHGQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQV 354  human
AAH64000      297 IHSAFFHGQILTDKRQHVDTVSLFPATFVNVEMVADNPGQWLLSCQVNDHLEAGMQAFFEI 357  zebrafish
CAG00485      228 VHSAFFHGNTVLDRGHRTDVLSLFPATFATAEMVPQARGKWLLTCQNRDHLKAGEQAFYEV 288  Tetraodon nigroviridis
Q9BQS7        303 VHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKV 363  human
NP_001092142  303 IHSIYFYGNTFISRGHRTDVVNLFPATFLTTEMIAENPGKWMITCQVSDHLQAGMLGQYNV 363  human
XP_001235149  296 IHSAYFHGQTLIERHHRVDTINLFPATFIDALMIPRNPGEWLLSCQVNDHIEGGMQALFKV 356  chicken
XP_002937375  294 IHSAYFHGQVLTFQMYRVDTLSLFPATMIEGHMVTKNPGKWLLTCQVNDHLAGGMQAIYEV 354  western clawed frog

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