2J5W,1KCW


Conserved Protein Domain Family
CuRO_6_ceruloplasmin
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cd11012: CuRO_6_ceruloplasmin 
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The sixth cupredoxin domain of Ceruloplasmin
Ceruloplasmin is a multicopper oxidase essential for normal iron homeostasis and copper transport in blood. It also functions in amine oxidation and as an antioxidant preventing free radicals in serum. The protein has 6 cupredoxin domains with six copper centers; three mononuclear sites in domain 2, 4 and 6 and three in the form of trinuclear clusters at the interface of domains 1 and 6. Ceruloplasmin exhibits internal sequence homology that appears to have evolved from the triplication of a sequence unit composed of two tandem cupredoxin domains. This model represents the sixth cupredoxin domain of ceruloplasmin.
Links
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Statistics
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PSSM-Id: 259898
Aligned: 5 rows
Threshold Bit Score: 291.002
Created: 4-Jun-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: Type 1 (T1) Cu binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:H C H MClick to see conserved feature residue pattern help
Evidence:
  • Structure:1KCW; Human Ceruloplasmin domain 6 binds copper at T1 center.
  • Comment:Type 1 (T1) copper sites are characterized by their conserved H...C...H...M copper ligands.
  • Comment:Some members bind copper at the T1 site with three amino acid residues (HCH), instead of four (HCHM).
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
2J5W_A        913 KLEFALLFLVFDENESWYLDDNIKTYSDHPEKVnkDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNEID 992  human
1KCW_A        894 KLEFALLFLVFDENESWYLDDNIKTYSDHPEKVnkDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNEID 973  human
AAH64000      927 VEEFALLFMVFDENESWYLEENIKTHVKNPPKAltEDQQFIESNKMHGINGLVFGNLKGLNMKVGDKVYWYLMGLGNEVD 1006 zebrafish
XP_001235149  909 KVRFALLFMVFDENESWYLDENIETYSANPHLVdkENEEFLESNKMHAINGKVFGNLHGLTMHVGDEVSWYLMAMGNEID 988  chicken
XP_002937375  908 PKRFALLFLIFDENESWYLDENIKTYSLHPDQVqkEDEDFIESNKMHGINGKLYANLEGLTMHVGDKIYWHLIGLGNEAD 987  western clawe...

Feature 1          #                                             #    #    #       
2J5W_A        993 LHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHAGMETTYTVL 1057 human
1KCW_A        974 LHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHAGMETTYTVL 1038 human
AAH64000     1007 IHTAHFHGHSFDYKVSGTHRADVFDLVPGTFQTVTMRPLYSGTWLLHCHVTDHIQAGMETTYTVL 1071 zebrafish
XP_001235149  989 IHTAHFHGHSFDYKQTEVYRADVFDLFPGTFQTVEMIPQNPGVWLLHCHVTDHIHAGMEATYTVL 1053 chicken
XP_002937375  988 IHTMHIHAHSFTYVRGATFHSDVYDLFPGTFKTVEMIARVPGTWLLHCHVTDHIHAGMEVLYTVL 1052 western clawed frog

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