1QM6,1QM6,1AK0


Conserved Protein Domain Family
ZnPC_S1P1

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cd10981: ZnPC_S1P1 
Click on image for an interactive view with Cn3D
Zinc dependent phospholipase C/S1-P1 nuclease
This model describes both the bacterial and archeal zinc-dependent phospholipase C, a domain found in the alpha toxin of Clostridium perfringens, as well as S1/P1 nucleases, which predominantly act on single-stranded DNA and RNA.
Statistics
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PSSM-Id: 211380
Aligned: 20 rows
Threshold Bit Score: 165.693
Created: 7-Apr-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding site
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 7 residue positions
Conserved feature residue pattern:H H H D H H EClick to see conserved feature residue pattern help
Evidence:
  • Comment:the zinc-binding site is the putative active site of these enzymes
  • Structure:1QM6: The phospholipase C domain of Clostridium perfringens alpha-toxin binds two zinc ions, contacts at 4 A
  • Structure:1AK0; Penicillium citrinum P1 nuclease with bound zinc
  • Citation:PMID 9726413

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #                                                           #               
1QM6_A         7 GTGTHAMIVTQGVSILEndlsknepesvrknleilkenmheLQLGSTYPDYDknayd---lyqdHFWDPdtdnnfskd-- 81  Clostridium per...
YP_002250644  30 SAKTHQKIAKEALYSLPkeyqrkl-----------spyldeLLEGSVAPDRIykd------fnnHVFHVhg--------- 83  Dictyoglomus th...
YP_003370295  13 CRSTHHKLAIDALRHLQlpdnerwvd-------lflryhgaYLEGAKAPDDKfkd------frnHVLHVqd--------- 70  Pirellula stale...
YP_003756500  13 ANGTHHKLALDGLDAMPrkdkeawsr-------vmlkhverFLEGSKAPDVTfkd------fknHVLHVse--------- 70  Hyphomicrobium ...
YP_759538     84 CRSTHHFIAFDALSLLEgdeaegwks-------lmlvhhehLLKGAKAPDDTfkd------fknHVLHVge--------- 141 Hyphomonas nept...
YP_003629287  13 CKNTHHKLALDALRYLEipdaerwsd-------lfltridqYLDGSKAPDDKfkd------fqnHVLHVrd--------- 70  Planctomyces li...
YP_004270362  13 AKGTHHKLAMDALELLSveyadewsd-------lflrhiesYLTGAKDPDKKfrd------frnHVLHVhd--------- 70  Planctomyces br...
1QM6_B         7 GTGTHAMIVTQGVSILEndlsknepesvrknleilkenmheLQLGSTYPDYDknayd---lyqdHFWDPdtdnnfskd-- 81  Clostridium per...
1AK0_A         2 GALGHATVAYVAQHYVSpeaaswaqg------ilgsssssyLASIASWADEYrltsagkwsaslHFIDAednpptncn-- 73  Penicillium cit...
YP_004345428  41 GFFGHKRINRLATFSLPpemfgff-----------keniefITEHAVDPDKRrygvd--geaqrHYIDIdhyavngqdpf 107 Fluviicola taff...
Feature 1                                                                 #   #     #            
1QM6_A        82 ------------nswylaysiPDTGESQIRKFSALARYewqr-gnykQATFYLGEAMHYFGDIDTPYHpanvt------- 141 Clostridium per...
YP_002250644  84 --------------------dKGKGPEEVREKYLEIISliqegkswrLVAFQLGVLSHYIADLNNPLHtdssk------- 136 Dictyoglomus th...
YP_003370295  71 -------------------nyWGGAVTTAQKWYDATVQafrn-hlweEAVYSAGVLSHYYSDPLMPLHtgqse------- 123 Pirellula stale...
YP_003756500  71 -------------------nyWGGAPEKAAEWYRRTVSelqa-gnwpDAAYAAGVLSHYYTDPVMPFHtgqte------- 123 Hyphomicrobium ...
YP_759538    142 -------------------geWGGARAKAAEWYAIAVDllrr-krwsDAAWALGVLSHYYADPIQPFHtgqte------- 194 Hyphomonas nept...
YP_003629287  71 -------------------reWGGAIKTAQIWYEKAVTafrq-kdwsQGVYSAGVLSHYVTDPFQPFHtgqse------- 123 Planctomyces li...
YP_004270362  71 -------------------dfWGGAIKATQEWYGKGRQafad-grwkDGVYSAGVMSHYLTDVFCPLHtgqsd------- 123 Planctomyces br...
1QM6_B        82 ------------nswylaysiPDTGESQIRKFSALARYewqr-gnykQATFYLGEAMHYFGDIDTPYHpanvt------- 141 Clostridium per...
1AK0_A        74 ------------vdyerdcgsSGCSISAIANYTQRVSDssl---sseNHAEALRFLVHFIGDMTQPLHdeayavggnkin 138 Penicillium cit...
YP_004345428 108 elvpkkwteavakfsedtlqaYGIVPWHILVMKNRLQKafes-knidLILKNATEIGHYIGDAHVPLHttenyng----- 181 Fluviicola taff...
Feature 1                  #   #                                                                 
1QM6_A       142 ----avdsaGHVKFETFaeerkeqykintagck-----------tneafytdilknkdfNAWSKEYARGFAKTGKSIYYS 206 Clostridium per...
YP_002250644 137 -----redeFHSKYEKDadvinpk----------------------------ikseliyIKYPASYILDSIFSANRFYKD 183 Dictyoglomus th...
YP_003370295 124 -----aegtVHRALEWSvtksygelqqiidh---------------dqggyprvempegDDWLKEMIHSGARLANAHYDV 183 Pirellula stale...
YP_003756500 124 -----aenaIHRAAEWSinrsynalraige----------------krfadvdapvptgANWLKEFVCDGAEYSHRYYEK 182 Hyphomicrobium ...
YP_759538    195 -----aegvIHRAVEWSiarsrpeidaria-----------------eqgypdveipegMGFVSDMVREGALRSHAYYDV 252 Hyphomonas nept...
YP_003629287 124 -----aetiVHRAAEWTiacsydqlrllldq---------------elggvpakslpqgVEWLPQIIRQGAQFANQSYEL 183 Planctomyces li...
YP_004270362 124 -----kentIHRACEWSvscsyddlithlle---------------dlegypsvkldsdEDWLAKLIKAEATHANFLYST 183 Planctomyces br...
1QM6_B       142 ----avdsaGHVKFETFaeerkeqykintagck-----------tneafytdilknkdfNAWSKEYARGFAKTGKSIYYS 206 Clostridium per...
1AK0_A       139 vtfdgyhdnLHSDWDTYmpqkligghalsdaeswaktlvqniesgnytaqaigwikgdnISEPITTATRWASDANALVCT 218 Penicillium cit...
YP_004345428 182 --qmtgqrgIHGLWESRiveinaeey------------------------dyfvgkgkyIPNVLDFAWDAVKASNAAVDS 235 Fluviicola taff...
Feature 1                                                          
1QM6_A       207 HAsms----------------hswDDWDYAAKVTLANSQKGTAGYIYRFL 240 Clostridium perfringens
YP_002250644 184 IEkayls-------------gdkfRDVSKITQEQIDKAALDTASYFYSAL 220 Dictyoglomus thermophilum H-6-12
YP_003370295 184 LIdhynlsegv-----rnpllgmdQESKDRVARCLGTAVVGFARILERAI 228 Pirellula staleyi DSM 6068
YP_003756500 183 LIahydihkgt-----vrpedgldDVARTIVAELLMYAAKGYGRVLDAAI 227 Hyphomicrobium denitrificans ATCC 51888
YP_759538    253 FIghydleagv-----adppsgldETMRTAIVELVSYATAGFAAIMMRAI 297 Hyphomonas neptunium ATCC 15444
YP_003629287 184 AIshyslaigs-----kkpvegydETGKRAIARILGETIRGYALVLGECL 228 Planctomyces limnophilus DSM 3776
YP_004270362 184 LVegynfnagv-----kdppagldENLQKEMALTLGRATVSLSQVLDRML 228 Planctomyces brasiliensis DSM 5305
1QM6_B       207 HAsms----------------hswDDWDYAAKVTLANSQKGTAGYIYRFL 240 Clostridium perfringens
1AK0_A       219 VVmphgaaalq----tgdlyptyyDSVIDTIELQIAKGGYRLANWINEIH 264 Penicillium citrinum
YP_004345428 236 VLtiekeltaefpsdqkytyetrgNVVIQTYSKAFCDEYQNRMNGMVERR 285 Fluviicola taffensis DSM 16823

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