Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria
This family contains an uncharacterized protein BH1492 from Bacillus halodurans, an uncharacterized protein ATU2773 from Agrobacterium tumefaciens C58, and other bacterial hypothetical proteins. Although their functions are still unknown, structural superposition and sequence comparison suggest that BH1492 and ATU2773 might be divergently related to the 7-stranded barrel catalytic domain of polysaccharide deacetylases (DACs) from the carbohydrate esterase 4 (CE4) superfamily, which remove N-linked acetyl groups from cell wall polysaccharides. This family is designated as DAC family 2, a divergent DAC family.
Comment:Zinc-binding motif (His-His-Asp) is well conserved in most family members with some exceptions, for instance, Agrobacterium tumefaciens protein ATU2773 (2QV5) and its homologs lacks the zinc-binding motif.
Structure:2NLY; Bacillus halodurans hypothetical protein Bh1492 binds Zn2+.
Jiyao W et al.(2023). "The conserved domain database in 2023.",