2B5D


Conserved Protein Domain Family
GH57N_AmyC_like
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cd10792: GH57N_AmyC_like 
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N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins.
Alpha-amylases (alpha-1,4-glucan-4-glucanohydrolases, EC 3.2.1.1) play essential roles in alpha-glucan metabolism by catalyzing the hydrolysis of polysaccharides such as amylose starch, and beta-limit dextrin. This subfamily is represented by a novel alpha-amylase (AmyC) encoded by hyperthermophilic organism Thermotoga maritime ORF tm1438, and its prokaryotic homologs. AmyC functions as a homotetramer and shows thermostable amylolytic activity. It is strongly inhibited by acarbose. AmyC is composed of a N-terminal catalytic domain, containing a distorted TIM-barrel structure with a characteristic (beta/alpha)7 fold motif, and two additional less conserved domains. There are other two canonical alpha-amylases encoded from T. maritime that lack the sequence similarity to AmyC, and belong to a different superfamily.
Links
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Statistics
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PSSM-Id: 212104
Aligned: 65 rows
Threshold Bit Score: 503.968
Created: 17-Aug-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               # # #                #                                                   
2B5D_X         3 GKILIFLHAHLPYVHHPEyd--hfLEERWLFEAITETYIPLLMMFDEIe----dFRLTMSITPPLMEMLSSRDLQEKYER 76  Thermotoga mari...
YP_004247277   4 NSVAFILNAHLPFVRHPEyp--rfLEEDWLFESISESYLPLLRMFNKLkaekipFKFTISLSPTLCGMLTDAVLQERFVQ 81  Spirochaeta sp....
YP_004411267   4 NHVHFILQAHLPFVRHLEyt--rfLEEDWLFESIVESYLPLLRAFRRLradgvpFKVTVSLSPTLCAMLDDEPLRQRFLS 81  Spirochaeta coc...
O83377         7 HSLAFVLDCNLPFVRGAGas--slLAESRFFLEISYTYLPLLRLCETLerervpFNISLAIGPVLCEMLANRVLMDRYRR 84  Treponema pallidum
YP_004531411   5 RVISILLNLHKPFVRHPEas--qaLEEQWFFETLSDTCLPLLELFDRLdaehipFRMALALSPTLCHLLRDELLLERYLQ 82  Treponema primi...
ZP_05622874    4 KTLLFIFHAHVPYIPHADgd--epLEAAQFYELLSYGFLPFLRMCERLdadtvpFKCALVISPLLCEMLNSSFCRERYGA 81  Treponema vince...
ZP_08037036    7 RSIIFVFDLRLPYCRDSTes--gsIAETWLFQEVFYNYLPLLRMCRNLekeaipFHFAMAISPVICEMLADSKIATRCMQ 84  Treponema phage...
Q73NQ8         4 YKLIFILDAHLPYVCNEVeq--glIEEDWLFDALSYLYLPVLKMCSNLqkenipFKIGVVFEPALCDMLDDKVLQDRYRQ 81  Treponema denti...
YP_004440144   4 KSFVITLVAHQGYIRRTDgdsfgrPENELLFLAISETYIPLLNMFESLdtdavpFKLSMVITPTLCSLLSDTAVINRYVD 83  Treponema brenn...
YP_004365670   4 KKLVLIIEANQGYIPQTEdkegfqVQNSILFSAITETYIPLLNMFCQLekenipFKLGLVISPSIYALLSDSSIQDKYIE 83  Treponema succi...

Feature 1                                                                              #         
2B5D_X        77 HMEKLIELANKEVERtkke-hplkHKMAKFYREHFEKILNVFRSYdgNILEGFKKYQEtGKLEIVTCNATHAFLPLYqmY 155 Thermotoga mari...
YP_004247277  82 YLERLMELGEKEVERcrteqpeflEMAQFYLDQAKRNLSDYQDLYrtNILDGFKALETsGHLELITTAATHAYLPLYkeY 161 Spirochaeta sp....
YP_004411267  82 YVEIHRELGRKEIERceaeqpeclPLARMYSDIYEQTYSDYTALYqyDVLEGFRNLEEsGHLDIITTAATHAYLPLYaeF 161 Spirochaeta coc...
O83377        85 ALDALIEFGEREAIRlrns-lqerVQAEAVLRSLRSHRDYFDHCDg-ALLERINHFFRtGSIELLATTAVNCFLPFYqdM 162 Treponema pallidum
YP_004531411  83 FVDRQIEFGVQELDRsssd-pelhRLALEFYDRAVDKRVLFTERYegNILKIFDYYQRkGRLELLTTAATYAFLPLYtgY 161 Treponema primi...
ZP_05622874   82 YLDRQIAFARQELKRaaga--preALIRHALEFFTLNREDFNVRYkkDILSRINSFAAkDCIELLATSATPCFFPFYqdM 159 Treponema vince...
ZP_08037036   85 KLELLIDLGKRELVRlenf-plerAQAEAVLHCLLQNKEDIENGY--TILKSIDYFASrGNIELLATTATNCFLPFYqtM 161 Treponema phage...
Q73NQ8        82 HVQRKIEFAKKELECfaec-aetkKLIQYNLKRFNDDKRIFEDCGg-NVLKQFDYLARqGYVELLATTATNSFLPFFlsM 159 Treponema denti...
YP_004440144  84 WLDRSIVLGEKELTRnasd-tgrkKQAQRCLDRVRKTRQDFIEVYkrDLLSAFRYYADrGNVELLATAATYAFLPHYadL 162 Treponema brenn...
YP_004365670  84 YLDELIKLGNAEVLRckds--nclEQAKTCLESIEKTKSDFTETYgkNLLEKIKYFEKlGIIELIPTAATFSYLPHYsdY 161 Treponema succi...

Feature 1                                  #  #                                                  
2B5D_X       156 PEVVNAQITVGVKNYEKHMkkHPRGIWLAECGYYQGLDLYLAQNNVEYFFVDSHafwfadeqprygVYRPIMTPsGVFAF 235 Thermotoga mari...
YP_004247277 162 PTAINAQIELGVQSFLTTFghLPKGFWLPECGYYPGLEENLKYHGISWFQTASQsmllspdkvqygDYRPIRCPnGVAAF 241 Spirochaeta sp....
YP_004411267 162 PTAIYAQVETAIQSYIRHFkkSPKGFWLPECGYVPGFEEYLRRQGISWFPIAASslaladtpafrgMFSPVMTPgNVAAF 241 Spirochaeta coc...
O83377       163 PESISAQIXMGLINYRKHFssIPRGFYLPELGYAPALERTIKSYGFSYTILETHsflfgtrvprrgIFEPAQTSnGLWCL 242 Treponema pallidum
YP_004531411 162 PEAIQAQMEVAIASHRILFgrTPHGFWLPELGWSPEIDRYLRSYNFSYTIVDSHslllgepgasrgSFYPVSTPtGVFAL 241 Treponema primi...
ZP_05622874  160 PEALTAQIEQGLSSFRENFatTPFGFWLPLMGYDAGVDRIIKSYGIDYTVLETQsflfadrppvngIFSAAMGEsGFSFF 239 Treponema vince...
ZP_08037036  162 PEAIAAQIEMGLINYRKHFstIPTGFWLPELGYNSGLEKMIKAYGFTYTVLETHsflfsdrlprrgVFEPSMAEnGLIFL 241 Treponema phage...
Q73NQ8       160 PEAIAAQIEMGQINYRKHFssVPSGFWIPSMAYFDGLDDIIRSYGYDYTVVSSEgfllsdkvppagVFSAAASKnGLKFL 239 Treponema denti...
YP_004440144 163 PEAVNAQIETGVQAHRHFFgvVPEGFWLPYMGFSSGLEQVLRGYGFDYTVLNSHgvlfadplpekgIFAPVRCGnSFALF 242 Treponema brenn...
YP_004365670 162 PEAINAQIETGLYSQRIFFgdTGDGFWLPYMGWNKSLERPLRSYGINYTILDARailfseqcpqegIFSPVRTKsSLVIF 241 Treponema succi...

Feature 1         #       ###   # ##                                                             
2B5D_X       236 ARDPESSEQVWSaAVGYPGDPRYREFYRDIGfdremeyikdyidpsgvrintgikyhritsksldasqKEYYDIDLAMEA 315 Thermotoga mari...
YP_004247277 242 PRDFQGTSLVWSnTSGYPTDKAYREFYRDIGydlpmeyikpyihepqv---rvftgykywaitghtdqKVPYQRALAQQK 318 Spirochaeta sp....
YP_004411267 242 PLNYHLTNLVWSnEEGYPGDPDYREFYRDIGydlpldyirpyihepdv---rvftgfkycavtghtdqKKTYVPQKAHEK 318 Spirochaeta coc...
O83377       243 GKDRVATAEVHGaTHSFCTQAVYGNTEQDAGfilpeealyplfeph--------kermatgylyqarsGTPYEQEKAQRT 314 Treponema pallidum
YP_004531411 242 ARDFYARRELEG-LQDPLYRDYYRDAGYDLPaesvksflepsgark-------atgykywavgdksknKQLYDPALARER 313 Treponema primi...
ZP_05622874  240 GKDSTACADIAHpETGFYLHPDYLDTDKDVGfeldgealstlfdvk--------kgrrttglcysrrsGSLYDEHAGAMQ 311 Treponema vince...
ZP_08037036  242 GRDRIASEEICGtRTSYANSADFADKEQDIGfilseeylqpllcln--------kerrvtgffyrtksGQTYDREKALRL 313 Treponema phage...
Q73NQ8       240 ACDLSACNSIYDeLNGFPQNKVYIDVENDVGfrqseeylasvfdtsk------grraigfrywsrdeeETPYDIQKAHAQ 313 Treponema denti...
YP_004440144 243 ARDDASEDELTG-PGGFMYNPVYRDPNRDVAfeasvgdldgfleadgt----rissgyaywnrnesagGCWYDCEAAAKQ 317 Treponema brenn...
YP_004365670 242 GSDPDTPQDIAG-EDGFSTNEAYRSQIRDIGfdleqeklgdffgktda---riptgfkywsnesedddLVPYNSAQAKKQ 317 Treponema succi...

Feature 1                                          #      #                                      
2B5D_X       316 VEEHARDFLHKKESQARrlmdi-mgvePVIVAPFDAELFGHWWFEGVFFLKRFFELVNESk-dLKLVTASEVIDTle--e 391 Thermotoga mari...
YP_004247277 319 IAEHAQNFIYSLKKKGQslssa-mdvaPLFTLAYDAELFGHWWFEGIDWLEQVIRLVAQQgedIALVTPSNFLSKeg-fa 396 Spirochaeta sp....
YP_004411267 319 AQMHADNFLYEIRRTGQnidsl-idvePSHTIAFDAELFGHWWFEGVDWLEAVIRKSASCp-dIVFDSPMDVLGSsmeds 396 Spirochaeta coc...
O83377       315 CVADARAFVRNRTEIFEkvvhatapfeAMSVCVFPASLFGVAWAEGMDWLEAVFRTVAESa--QMRVSCTAALTCpa-vg 391 Treponema pallidum
YP_004531411 314 AREHARSFLDSRMSRLTaageh-qdgiPLSLCAYDGDSFGRFWYEGPDFLEALFREGAKQe-gLQFMTPVEYLYKqdalg 391 Treponema primi...
ZP_05622874  312 AERDAERFVANRNAVLTeaaelldadpLCSVSVLPLRFLGKTWMEGIYWLESVFRKLAQLh-dMHCALPSEYLKKvr--r 388 Treponema vince...
ZP_08037036  314 AENQAAAFVAARKKIFDevediaqiphIASVCTFPISISGFTWAEGLHWLQTVFMLAAKDe-eVQTALPDAFAGAtr--r 390 Treponema phage...
Q73NQ8       314 ILADAESYVNSRAEALRavketgggesPFSLLIISSDFFGKKWCEGLIWLERVFRLINDNe-eLETMLPSDAANLsk--q 390 Treponema denti...
YP_004440144 318 AASDAKSFFAGKIGKLAaaekllpghdVSLVCAFDAKILGQSWAEGVSWLEQVFRIAASQs-dVRIGSYADLLTNrf--d 394 Treponema brenn...
YP_004365670 318 IINDALNFYTSKAEKLEqaanimqekdTVLVCAIPAEFLGQKWHEGVEWLENVIRCRASKr-gFEFELCKNLLDNqf--s 394 Treponema succi...

Feature 1                  #        #  
2B5D_X       392 VQIATPADSSWGagGYYETWLN 413 Thermotoga maritima MSB8
YP_004247277 397 LQTARPAFSSWGqgGYSAVWLD 418 Spirochaeta sp. Buddy
YP_004411267 397 LQTLTPGFSSWGtgGYSTVWLN 418 Spirochaeta coccoides DSM 17374
O83377       392 VSIIEPFFGSSLggGYADELIN 413 Treponema pallidum
YP_004531411 392 FETMMPEFSSWGtnGYAEMWLD 413 Treponema primitia ZAS-2
ZP_05622874  389 IQSISPFYASNLpsGYADELIN 410 Treponema vincentii ATCC 35580
ZP_08037036  391 LSVIYPFYGSLLddGYAGSLIS 412 Treponema phagedenis F0421
Q73NQ8       391 LYTVKPFFSSFLksGYADELLT 412 Treponema denticola
YP_004440144 395 LQKLKPFMSAATgtGYGENMLD 416 Treponema brennaborense DSM 12168
YP_004365670 395 LPKIEPYQCSANglGYGEDLLD 416 Treponema succinifaciens DSM 2489

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