Conserved Protein Domain Family
PR-SET_PRDM17

?
cd10520: PR-SET_PRDM17 
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins
PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.
Statistics
?
PSSM-Id: 380918
Aligned: 8 rows
Threshold Bit Score: 161.433
Created: 8-Jan-2010
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
putative activeputative SAM
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Mus musculus PRDM9 binds H3k4me2 and S-adenosylhomocysteine (AdoHcy) through its PR-SET domain.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                      #   ###                 #                                         
Q9H9D4        53 ALKSLPRGLALGPSLAkEQRLGVWCVGdpLQPGLLWGPLEEESaskekgegvkprqeen--------------------- 111  human
NP_079017     53 ALKSLPRGLALGPSLAkEQRLGVWCVGdpLQPGLLWGPLEEESaskekgegvkprqeen--------------------- 111  human
XP_005987038  56 ALGTLPPGLAVGPSRAqEKRMGIWCVEtaLQKGIFFGPLEGDLerhditgrrtpqehtrlkicegeikaqgfndnkiegy 135  coelacanth
XP_007903024  62 AFYTLPLGLAAGPSQLrQNRLGIWCVAkrIAKGTFFGPLEGKLewhdltgigslhpkefre------------------- 122  elephant shark
NP_001315204  21 ALRSVPLGLTVGPSLAeDEQLGLWCVGrvLKKDTLLGLEEPGEtiskekeeglqna------------------------ 76   zebrafish
XP_007069809  28 ALRSLPPGLALGPSLAqEPGMGVWCVGraLPPGALLGPRAEEElgcaaerapseaiq----------------------- 84   green sea turtle
PIO38692      42 ALCSLPRGLALGPSLSqGEGLGLWCVGdhLPAGSFLPPHIHETgdglldnqen--------------------------- 94   bullfrog
XP_015194161  55 LLRTLPPGLALGPSLArGSCIGVWCVGkaVHKGAFFGPLENCAhptgvdeteegrgpn---------------------- 112  spotted gar
Feature 1                                     ##### #        ##                       ##    
Q9H9D4       112 ----------lslgpwgdvcaceqssGWTSLVQRGRLEseGNVAPVRisERLHLQVYQLVLPGSELLLWPQPSSE 176  human
NP_079017    112 ----------lslgpwgdvcaceqssGWTSLVQRGRLEseGNVAPVRisERLHLQVYQLVLPGSELLLWPQPSSE 176  human
XP_005987038 136 fvfvlppffffffffspfffffffffKPSSFASLAQSKeeRNVAEFTlrGKIYFRVCKVIEPGAELLVWPEDATV 210  coelacanth
XP_007903024 123 --------ngatdtspelgivseslsNWMRYTNWAETKeeSNASVFLscGKMYFRVWKTIELGQELLLWPEENQA 189  elephant shark
NP_001315204  77 -------------sqsvykreisdevCWMQFACSAQSAeeSNVSVLKvdGRLGLKVCRDIQPGTELLLWESHPEA 138  zebrafish
XP_007069809  85 ------------sgccsdesicerspSWRRLVKRGRGEdeANVALVWisGRLHVRVRRPIAAGTELLYWPTEAQA 147  green sea turtle
PIO38692      95 ----------------qtsllpetvlKWVRFARSSPKH--VNVRICNlsGSLHLQVISPIQPGSELLILQEDNGN 151  bullfrog
XP_015194161 113 ------------seqtidplpleeagNWIRFACRAGSEgeWNACVLRlrGRPYVKALEDIEPGVELLLRPGEEGE 175  spotted gar

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap