2W5Z,4Z4P,6BX3,2W5Y


Conserved Protein Domain Family
SET_SETD1-like
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cd10518: SET_SETD1-like 
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins
This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).
Links
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Statistics
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PSSM-Id: 380916
Aligned: 29 rows
Threshold Bit Score: 194.738
Created: 6-Jan-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2W5Z; Homo sapiens MLL1 binds cofactor product S-adenosylhomocysteine and histone peptide through its SET domain, contacts at 4A.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                 ####                #                         ######    
2W5Z_A         39 MPMRFRHLKKTSKe--AVGVYRSpIHGRGLFCKRnIDAGEMVIEYaGNVIRSiqTDKREKYYDSkg-iGCYMFRIDdSEV 115  human
6BX3_E        128 ELLSLNQLNKRKK---PVMFARSaIHNWGLYALDsIAAKEMIIEYvGERIRQpvAEMREKRYLKngigSSYLFRVDeNTV 204  Saccharomyces...
EAY23271       85 HPKDFQSIRSQLK---YLRFEKSgIHLWGVFSACyFAPGEPIVEYtGELVRLsvTEARQKYYETegnhGSYIFRLDdDLY 161  Trichomonas v...
AFP65504      171 FPKRNCDILVSLKlenKLSISLSqKHGWGIFVKYfLKKMTFISEYrGKYIQNykTDFLESYYRYvn-kNLFFFKLNsFIT 249  Chroomonas me...
XP_004991355 1875 DAMQYRQCKERMRe--TVRVGYSkIHGFGLYAQRdISGGEMIVEYvGEVIRPelTDKREQFYDArn-mGSYMFRIDdKQV 1951 Salpingoeca r...
Q9UPS6       1815 DLLKFNQLKFRKK---KLKFCKShIHDWGLFAMEpIAADEMVIEYvGQNIRQviADMREKRYEDegigSSYMFRVDhDTI 1891 human
EME27810      644 DSLIISQLKSRKK---RVRFGRSiIHGWGLYAMQdIEPNEFIIEYvGEIIRQkiSDEREKRYFRqgigDSYMFRLDeDQI 720  Galdieria sul...
ETO31971      336 NLLQINSLKYREK---KLKFDKSnVHSWGVFALEdIPPQELVVEYiGEYITNemADEREKEYAKrg-fDDYMFRVDsQLI 411  Reticulomyxa ...
XP_002291362   27 ASKTVDRLVSRDRe-eRLRFDKSlIHGWGVFAEEaINAGDMIIEYrGELIGNavADKRELEYERakigSDYMFRIDeFWV 105  Thalassiosira...
EEY55136     2789 ITMQYRELRRRPFd-eRMLVRKSsIHGYGLFLKEpVSDGQMIVEYqGQMINQtiADERERRYEEqgvgSCYMFRLDeKTI 2867 Phytophthora ...

Feature 1                  ######       ###         #               ######         ####      
2W5Z_A        116 VDATMhGNAARFINHSCePNCYSRVINIdg-qkHIVIFAMRKIYrGEELTYDYKFPieda-snklPCNCGAKKCR 188  human
6BX3_E        205 IDATKkGGIARFINHCCdPNCTAKIIKVgg-rrRIVIYALRDIAaSEELTYDYKFErekddeerlPCLCGAPNCK 278  Saccharomyces cere...
EAY23271      162 IDATHkGGIARFLNHSCdPNCKTCVVEAgg-qrHIVIFAKKKIEpFEELTYDYNLPyesk-ekaiVCLCGSPKCR 234  Trichomonas vagina...
AFP65504      250 IDATFsGNIGRYINHSCsPNCFTKNINHgv-edFIILISSKNIKlFEELSYDYRINpdefdiqqtICVCENVTCR 323  Chroomonas mesosti...
XP_004991355 1952 VDATLtGGQARFVNHSCdPNCISRIISTdr-gkKIVIVAKQHICkGDELTYDYQFPlddd--nkvRCSCGAANCR 2023 Salpingoeca rosetta
Q9UPS6       1892 IDATKcGNFARFINHSCnPNCYAKVITVes-qkKIVIYSKQHINvNEEITYDYKFPied---vkiPCLCGSENCR 1962 human
EME27810      721 IDATRkGSVARFVNHSCeSNAVAKIITIdn-skKIVFYSKRLIRaGEEITYDYKFNtede-nnkiLCLCGAPTCR 793  Galdieria sulphuraria
ETO31971      412 IDATMkGNIARFINHSCdPNCATRIISVdn-tmRVVIYSKKFISkGEELCYDYKFPiedn--nkiPCLCGTIKCR 483  Reticulomyxa filosa
XP_002291362  106 CDATKlGNVARFINASCcPNCYTKIITAne-tkRIVIFAKKNIQrGEELCYDYKFQmehekekriPCYCGSSECR 179  Thalassiosira pseu...
EEY55136     2868 IDATRcGNLARFINHSCdPKAFARIVAVeggekKIVIFAKRAIAvGDEVTYDYKFPied---eaiRCDCNAPNCI 2939 Phytophthora infes...

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