1QYP


Conserved Protein Domain Family
Zn-ribbon_TFS
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cd10511: Zn-ribbon_TFS 
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C-terminal zinc ribbon domain of archaeal Transcription Factor S (TFS)
TFS is an archaeal protein that stimulates the intrinsic cleavage activity of archaeal RNA polymerase. TFS C-terminal domain shows sequence similarity to the homologous C-terminal zinc ribbon domain of subunits A12.2, Rpb9, and C11 in eukaryotic RNA Polymerases (Pol) I, II, and III, respectively and domain III of TFIIS. TFS is not a subunit of archaeal RNA polymerase even though its domains arrangement is similar to A12.2, Rpb9, and C1. TFS is a transcription factor with a similar function to eukaryotic TFIIS. TFS has external cleavage induction activity and improves the fidelity of transcription. TFS has two zinc-binding domains.
Links
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Statistics
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PSSM-Id: 259795
Aligned: 23 rows
Threshold Bit Score: 73.9231
Created: 25-Sep-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding site
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:The zinc ribbon is the most conserved part of RPB9, RPC11, RPA12 subunits of RNA polymerases and it is homologous to TFIIS domain III and the C-terminal zinc ribbon domain of archaeal Transcription Factor S. Three antiparallel b-sheets are stabilized by a tetrad of cysteines that chelate zinc
  • Structure:1QYP_A, Archaeal TFIIS (TFS) domain III contacts Zn ion at 4.0 A
  • Citation:PMID 9634694
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #  #                             #  #       
1QYP_A     10 TLPTTKi-TCPKCGNDTA-----YWWEMQTRAGDEPSTIFYKCTKCGHTWRSY 56  Thermococcus celer
EGQ43510   64 TRPTTNk-ECPSCSDSSEdekehEWWMEQTRSSDEPPTRFYKCRECGNVHKEY 115 Candidatus Nanosalina sp. J07AB43
NP_394466  53 AEPLDSdaVCPRCHHKGA-----RYVLKQTRSADEPETKFYTCEECGYRWREY 100 Thermoplasma acidophilum DSM 1728
EFD93116   33 LDFEKGm-ECPKCKEKKI-----VSWMEQTRASDEPPTRFYKCVNCGYTWREY 79  Candidatus Parvarchaeum acidophilus ARMAN-5
NP_279494  56 GLPTTSv-VCPDCDNDEA-----HWYMQQIRSADESETRFFICTECEHRWRED 102 Halobacterium sp. NRC-1
NP_280494 172 GKPTAEe-TCPECGHGEA-----WYTIKQTGSADEPPTRFFKCQDCGNRWRDY 218 Halobacterium sp. NRC-1
YP_920032  62 VLPVVSf-KCENCGNDKA-----YVYELQTRAGDEPATRFYICTKCRKVYREY 108 Thermofilum pendens Hrk 5
EHR77105   71 VLTTGTy-MCPKCDKMEV-----FSYLEQTRSSDEPETRMLTCKNCGHGWREY 117 uncultured marine group II euryarchaeote
ELZ71823   48 IGPTTKt-ICPKCGHDVA-----RYEMKQIRSADESETRFFTCVECDHKWRED 94  Haloferax gibbonsii ATCC 33959
ELZ19740  531 GLPSTTs-TCPDCSHERA-----HYRLVQLRSTDEPPTRLLSCVSCGRRWRED 577 Halosimplex carlsbadense 2-9-1

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