Conserved Protein Domain Family
Zn-ribbon_RPC11

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cd10509: Zn-ribbon_RPC11 
C-terminal zinc ribbon domain of RPC11 subunit of RNA polymerase III
The C-terminal zinc ribbon domain (C-ribbon) of subunit C11 (Zn-ribbon_RPC11) in RNA polymerase (Pol) III is required for intrinsic transcript cleavage. RPC11 is also involved in Pol III termination. Eukaryote genomes are transcribed by three nuclear RNA polymerases (Pol I, II and III) that share some subunits. RPC11 has strong homology to RPB9 of Pol II and RPA12 of Pol I. Zn-ribbon_RPC11 is homologous to Pol II elongation factor TFIIS domain III. C11 has two zinc-binding domains separated by a flexible linker.
Statistics
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PSSM-Id: 259794
Aligned: 55 rows
Threshold Bit Score: 70.6922
Created: 25-Sep-2006
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
Zn binding site
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:The zinc ribbon is the most conserved part of RPB9, RPC11, RPA12 subunits of RNA polymerases and it is homologous to TFIIS domain III and the C-terminal zinc ribbon domain of archaeal Transcription Factor S. Three antiparallel b-sheets are stabilized by a tetrad of cysteines that chelate zinc
  • Citation:PMID 9634694

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                #    #                        #     #      
NP_057394     61 NVDSTAeSCPK--CEHPRAYFMQLQTRSADEPMTTFYKCCNa-qCGHRWRD 108 human
CCA75784      50 WGNQTPaPCPK--CEHPMAHFMELQIRSADEPMTIFYKCANk-eCGFQWKE 97  Piriformospora indica DSM 11827
XP_002675306  63 WSETVEtKCGK--CDHNKAYFQMFQTRSADEPMTQFFKCCK---CGHQWKE 108 Naegleria gruberi strain NEG-M
EEA97306      60 RGAKAPaSCPK--CSHTEAYFYEIQIRSADEPMTAFYCCCN---CRFRWRE 105 Toxoplasma gondii ME49
AAC71847      61 NMSKTQaVCPK--CTNDEAYFYTLQIRSADEPSTIFYICVK---CNYHWKE 106 Plasmodium falciparum 3D7
EEA07713      60 ASAKVMaVCPK--CSNTEAYFFQLQIRSADEPMTSFYTCVK---CEHKWKE 105 Cryptosporidium muris RN66
EFN54463      64 NAPRTEaRCPSdtCGHLQAYFKEAQIRSADEPATLFYRCAK---CGRNWRE 111 Chlorella variabilis
NP_192535     60 TAAETEaPCPR--CGHDKAYFKSMQIRSADEPESRFYRCLK---CEFTWRE 105 thale cress
BAM42015      63 HSPKIPaVCPY--CNNNEAYFMSIQTRSADEPMTQFFVCTS---CTKRWRE 108 Theileria orientalis strain Shintoku
EKX38722      59 SMTDVIgGCPK--CGHPKAYFFSIQIRSADEPATRFYRCARgaeCTYTWKE 107 Guillardia theta CCMP2712

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