3HEI,3GXU,3NRU,3MX0


Conserved Protein Domain Family
EphR_LBD_A

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cd10473: EphR_LBD_A 
Click on image for an interactive view with Cn3D
Ligand Binding Domain of Ephrin type-A Receptors
Ephrin receptors (EphRs) comprise the largest subfamily of receptor tyrosine kinases (RTKs). Class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands. EphRs contain a ligand binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyrosine kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). Ephrin/EphR interaction mainly results in cell-cell repulsion or adhesion, making it important in neural development and plasticity, cell morphogenesis, cell-fate determination, embryonic development, tissue patterning, and angiogenesis.
Statistics
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PSSM-Id: 198441
Aligned: 10 rows
Threshold Bit Score: 307.828
Created: 9-Jun-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ephrin binding
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1:ephrin binding site [polypeptide binding site]
Evidence:
  • Structure:3MX0; human EphA2-ephrinA5 complex, contacts 4A
  • Structure:3GXU, human EphA4-ephrinB2 complex, contacts 4A
  • Structure:3HEI, human EphA2-ephrinA1 complex, contacts 4A

cd10473 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd10473 is a member of the superfamily cl02704
Sub-family Hierarchy
cd10319EphR_LBDcd10472EphR_LBD_Bcd10476EphR_LBD_B1cd10477EphR_LBD_B2cd10478EphR_LBD_B3cd10473EphR_LBD_Acd10479EphR_LBD_A1cd10480EphR_LBD_A2cd10481EphR_LBD_A3cd10482EphR_LBD_A4cd10483EphR_LBD_A5cd10484EphR_LBD_A6cd10485EphR_LBD_A7cd10486EphR_LBD_A8cd10487EphR_LBD_A10cd10474EphR_LBD_B4cd10475EphR_LBD_B6
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                  # #####      ## # #                                # # 
3HEI_M          1 EVVLLDFAaaggELGWLTHPygkgWDLMQNIMnd-mPIYMYSVCNVMs-gDQDNWLRTNWVYRge-aeRIFIELKFTVRD 77   human
NP_990436      36 EVNLLDSRtvmgDLGWIAYPkn-gWEEIGEVDenyaPIHTYQVCKVMe-qNQNNWLLTSWISNeg-asRIFIELKFTLRD 112  chicken
XP_003212606   27 AVVLMDSKesqaELGWTSHPan-gWEEISGVDeeykPIRTYQVCNVMe-pNQNNWLQTGWIARrd-gqRIFIELKFTLRD 103  turkey
XP_002190943   28 EVNLLDTStilgDWGWMTYPsh-gWDSINEMDeffsPIHTYQVCNVMt-pNQNNWLRTNWVQRdg-arRVYAEIKFTLRD 104  zebra finch
Q9UF33         33 QVVLLDTTtvlgELGWKTYPln-gWDAITEMDehnrPIHTYQVCNVMe-pNQNNWLRTNWISRda-aqKIYVEMKFTLRD 109  human
NP_076069      28 EVTLMDTStaqgELGWLLDPpetgWSEVQQMLng-tPLYMYQDCPIQeggDTDHWLRSNWIYRgeeasRIYVELQFTVRD 106  house mouse
3GXU_A          2 EVTLLDSRsvqgELGWIASPleggWEEVSIMDekntPIRTYQVCNVMe-pSQNNWLRTDWITReg-aqRVYIEIKFTLRD 79   human
3NRU_A          3 EVLLLDSKaqqtELEWISSPpn-gWEEISGLDenytPIRTYQVCQVMe-pNQNNWLRTNWISKgn-aqRIFVELKFTLRD 79   human
P29319         29 EVNLLDSKtiqgELGWISYPsh-gWEEISGVDehytPIRTYQVCNVMd-hSQNNWLRTNWVPRns-aqKIYVELKFTLRD 105  house mouse
3MX0_A          2 EVVLLDFAaaggELGWLTHPygkgWDLMQNIMnd-mPIYMYSVCNVMs-gDQDNWLRTNWVYRge-aeRIFIELKFTVRD 78   human
Feature 1            ##                                           #   ##  ###                     
3HEI_M         78 CNSFPgg--asSCKETFNLYYAESDldygtnFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGpLTRKGFYLAF 155  human
NP_990436     113 CNSLPgg--lgTCKETFNMYYFESDdedgrnIRENQYIKIDTIAADESFTELDLGDRVMKLNTEVRDVGpLTKKGFYLAF 190  chicken
XP_003212606  104 CNSIPgv--tgTCKETFNLYYAESDadlghsIRESKHTKIDTIAADESFTQGDLGERKMKLNTELREIGhLSKRGFHLGF 181  turkey
XP_002190943  105 CNSMPgv--lgTCKETFNLYYMESDrdlgssTRESQFLKIDTIAADESFTNVDLGVRRLKLNTEVRGVGpLSKRGFYLAF 182  zebra finch
Q9UF33        110 CNSIPwv--lgTCKETFNLFYMESDeshgikFKPNQYTKIDTIAADESFTQMDLGDRILKLNTEIREVGpIERKGFYLAF 187  human
NP_076069     107 CKSFPggagplGCKETFNLFYMESDqdvgiqLRRPLFQKVTTVAADQSFTIRDLASGSVKLNVERCSLGhLTRRGLYLAF 186  house mouse
3GXU_A         80 CNSLPgv--mgTCKETFNLYYYESDndkerfIRENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGpLSKKGFYLAF 157  human
3NRU_A         80 CNSLPgv--lgTCKETFNLYYYETDydtgrnIRENLYVKIDTIAADESFTQGDLGERKMKLNTEVREIGpLSKKGFYLAF 157  human
P29319        106 CNSIPlv--lgTCKETFNLYYMESDdhg-vkFREHQFTKIDTIAADESFTQMDLGDRILKLNTEIREVGpVNKKGFYLAF 182  house mouse
3MX0_A         79 CNSFPgg--asSCKETFNLYYAESDldygtnFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGpLTRKGFYLAF 156  human
Feature 1              ### #        
3HEI_M        156 QDIGACVALLSVRVYYKK 173  human
NP_990436     191 QDVGACIALVSVRVYYKK 208  chicken
XP_003212606  182 QDVGACVALVSVRVYYKK 199  turkey
XP_002190943  183 QDIGACIAIVSVRVYYKK 200  zebra finch
Q9UF33        188 QDIGACIALVSVRVFYKK 205  human
NP_076069     187 HNPGSCVALVSVRVFYQR 204  house mouse
3GXU_A        158 QDVGACIALVSVRVFYKK 175  human
3NRU_A        158 QDVGACIALVSVKVYYKK 175  human
P29319        183 QDVGACVALVSVRVYFKK 200  house mouse
3MX0_A        157 QDIGACVALLSVRVYYKK 174  human

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