3MCY,3JWN,1KLF,2VCO,1QUN


Conserved Protein Domain Family
FimH_man-bind
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cd10466: FimH_man-bind 
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Mannose binding domain of FimH and related proteins
This family, restricted to gammaproteobacteria, includes FimH, a mannose-specific adhesin of uropathogenic Escherichia coli strains. The domain appears to bind specifically to D-mannose and mediates cellular adhesion to mannosylated proteins, a prerequisite to colonization and subsequent invasion of epithelial tissues.
Links
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Statistics
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PSSM-Id: 198456
Aligned: 19 rows
Threshold Bit Score: 128.231
Created: 4-Apr-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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mannosyl
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:mannosyl binding site [chemical binding site]
Evidence:
  • Structure:3MCY: FimH from a uropathogenic E. coli binds to biphenyl-mannoside-meta-methylester, contacts at 4 A
  • Structure:1KLF: FimH from a uropathogenic strain of E. coli binds alpha-D-mannose, contacts at 4 A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #           #                                       ###        # #              
3MCY_A         1 FACKTaNGTAIPIg--GGSANVYVNLAPVVNv--gQNLVVDLST---QIFCHNDYPE-----TITDYVTLQRGSAYGGVL 68 
Q1ZU85        20 FTCRVrATGQIISyrgAKQADVTVSLVPKIGa--hENIIIDFSQgssEIDCKDDLPQ-----SLIDIFWPTEGNEFIAPE 92  Photobacterium ...
Q46686        10 LLCRNnQTGQTFQ---SGDSRFNITLSPTVQyd-kAITVLDLNQ---LVLCQNEDASg----QNYDYLRVRQGTGFSPSL 78  Escherichia coli
EFZ55418      25 FSCNV-DGGSSIG---AGTTSVYVNLDPVIQp--gQNLVVDLSQ---HISCWNDYGGw----YDTDHINLVQGSAFAGSL 91  Escherichia col...
YP_001455226  23 FTCKVnDTGQTMT---SGSANVYVNLTPSVGv--gQNLVVDLSS---SVSCKNDSSGg----SIIDYINLTSGSAFGGAL 90  Citrobacter kos...
Q53298        10 LLCRNnQTGQVFN---SGDTSFRVNVSPVVQyd-kSISVLDLSQ---LVSCQNEDSTg----QNYDYLKILKGSGFSPAL 78  Escherichia coli
YP_002153124  26 FTCKVaSTGQIVG---DGAANIRVNLTPRVEv--nQNLVVDLSQ---QILCKNDSYGgprdpIDVDHVNLVSGTTFGGAL 97  Proteus mirabil...
YP_002150783  23 FGCSV-DNGYDIE---SGNYNIYVQLEAEVQp--yQNLIVDLSR---HLKCWNSYGGw----QDVDHINLEPGTGLSGPL 89  Proteus mirabil...
ZP_08360145   33 MICQNiQSGVTFS---SGTQSFRVILKPKVSpg-dAITVFDLSD---FVRCMNEDPSg----NNYDYVKLRAGSGFPHNF 101 Escherichia col...
YP_004499569  33 LLCQNrQTGQEFH---QGSYDVYVDLPTQLVgdrqTFTLVNIEN---VLQCMNEDSSg----RNFDYVKVLRDGSTTTPK 102 Serratia sp. AS12

Feature 1                                                                                  # #   
3MCY_A        69 SN--FSGTVKYs--GSSYPF--PTTSETp--rVVYNSrtdkPWPVALYLTPVs--sAGGVAIKaGSLIAVLILRQTNNYn 138
Q1ZU85        93 KI--KNGSLDWw--GKRYSF--PMQAQPgn-sHEISDgayhPLDVKFTLSPTs--nANGVIIKkGQPIGYFEYHQKNRPa 163 Photobacterium ...
Q46686        79 DAk-TYGRLDFtnrLSGYSQtlPLQQDTkpteAYWQYgvwkPFPAKMYLYPEp--gVFGKLIHaGELVATVYVNKFSTMg 155 Escherichia coli
EFZ55418      92 QS--YKGSLYWn--NVTYPF--PLTTNTn--vLDIGDktpmPLPLKLYITPVg--aAGGVVIKaGEVIARIHMYKIATLg 161 Escherichia col...
YP_001455226  91 AA--FTGSVYWa--GNTYPL--PMNGNSs--vYTITHtdylGLPLRMYLTATg--aAGGVVINsGELIAQLNMHKVASDg 160 Citrobacter kos...
Q53298        79 DTk-TYGRLDFtsrPTGYARqlPLQFDLqvteAFYQYgvwkPFPAKLYLYPAp--gVFGKVINnGDLLATLYVNKFSTKg 155 Escherichia coli
YP_002153124  98 NN--FDGSLLWy--NSYYPI--PLYYDTk--vINIKDrnfiPLNLRLYLKSIg--aAGGKQINkGDLIAKIEMYKIADWd 167 Proteus mirabil...
YP_002150783  90 FN--FSGSVYWy--GNTYSL--PLNSATk--vLHIGDltpmPMPMMLYLTPInnspAGGVLIRsGETIATINMYKIADWd 161 Proteus mirabil...
ZP_08360145  102 GAk-TNGRLEYn--NYTYPS--PLTQDTyy-ySVYQYgmwqHLPLKLSLYPEl--gAFGKLINaGELIAVLNIQKESTYg 173 Escherichia col...
YP_004499569 103 LQqyAIAGLDFd-rWKGLSF--PLLQDTfy-ySVYKPgvwqPIPGRLFATLQv--pYVGAFIRqGDVVGTLRFLKESTIg 176 Serratia sp. AS12

Feature 1                  # #                
3MCY_A       139 ---------sDDFQFVWNIYANNDVVVPT 158
Q1ZU85       164 krskmknlraDGDTYGWRILAGNDVVIPT 192 Photobacterium angustum S14
Q46686       156 q-------eaGERNFTWRFYATNDVYIQT 177 Escherichia coli
EFZ55418     162 s--------gNPRNFTWNIISNNSVVMPT 182 Escherichia coli LT-68
YP_001455226 161 ----------NPNNFIWNIYASNNVVVPT 179 Citrobacter koseri ATCC BAA-895
Q53298       156 q-------eaGERNFTWRFYATNDVHIQT 177 Escherichia coli
YP_002153124 168 g--------gHPRFFTWNIYALNDVIMPT 188 Proteus mirabilis HI4320
YP_002150783 162 g--------gNPKYFTWEIVSKYDVTMPI 182 Proteus mirabilis HI4320
ZP_08360145  174 q-------daGISHFTWKFFADKDVYLQT 195 Escherichia coli TA206
YP_004499569 177 g-------aaDHKSFELRFIAKNDLIIQG 198 Serratia sp. AS12

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