Conserved Protein Domain Family
GIY-YIG_NifU
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cd10458: GIY-YIG_NifU 
GIY-YIG domain found in iron-sulfur cluster assembly proteins
This family includes a group of uncharacterized iron-sulfur cluster assembly proteins that transiently bind the iron-sulfur cluster before transfer to target apoproteins. These iron-sulfur cluster assembly proteins contains a GIY-YIG domain that shows statistically significant similarity to the N-terminal catalytic domains of GIY-YIG family of intron-encoded homing endonuclease I-TevI and catalytic GIY-YIG domain of nucleotide excision repair endonuclease UvrC. They also contain a C-terminal NifU-like domain that corresponds to a common region between the NifU protein from nitrogen-fixing bacteria and rhodobacterial species. The biochemical function of NifU is unknown.
Links
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Statistics
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PSSM-Id: 198405
Aligned: 4 rows
Threshold Bit Score: 117.65
Created: 23-Jan-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
GIY-YIG
Feature 1:GIY-YIG motif/motif A
Evidence:
  • Comment:consensus: GIYX(10,11)YIG used to define GIY-YIG nuclease superfamily.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             ###          ###                                                                
EFN53527          120 GVYALYDdkrnLQYVGYARNVVLAVKAHLArvgEERCAWVRVMVFANKAmqSRAALQREADNWLAEAg--------tLPP 191 Chlorella ...
jgi:MICPUN_113170  94 GVFAMYDpsdnMLYAGYAKDAISAVRTYVE---KGLGARVRVAIFANRAtaTRVNLRAEQDRWIGEWidsngggetaIPP 170 Micromonas...
XP_001691526      104 GVYCVYDsagaAAYVGYSRNMVLAIKGHLArvgPARCAAVRATVYGNKAmaSRANLERGVASWVEEQlg------gvVPP 177 Chlamydomo...
ABR16650          125 GVYAIYNnedqIQYVGYARNVVMSLKSHMDkvgPSRCCSVRVKIFTDPSllSRGRLEQEKNKWLDEYg---------LPP 195 Sitka spruce

Feature 1               
EFN53527          192 GN 193 Chlorella variabilis
jgi:MICPUN_113170 171 GN 172 Micromonas sp. RCC299
XP_001691526      178 GN 179 Chlamydomonas reinhardtii
ABR16650          196 GN 197 Sitka spruce

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