GIY-YIG domain of hypothetical proteins from Metazoa
Members of this family are functionally uncharacterized hypothetical proteins from Metazoa. They have bacterial homologs that display sequence homology with the catalytic GIY-YIG domain of bacterial UvrC DNA repair proteins. However, unlike their bacterial relatives, these Metazoan proteins contain an N-terminal extension that includes the region of approximately 3-4 ankyrin repeats, unique motifs mediating protein-protein interactions. Some of them do have an additional LEM domain located between ankyrin repeats region and GIY-YIG domain. The LEM domain, found in inner nuclear membrane proteins, may be involved in protein- or DNA-binding. The different domains composition suggests members in this subfamily might participate in interactions with multiple partners and imply some important cellular functions.
Comment:consensus: GIYX(10,11)YIG used to define GIY-YIG nuclease superfamily.
Comment:Members in this family have a variant GIY-YIG domain with FXY instead of the GIY motif. Besides, there are insertions between FXY and YIG motifs.
Jiyao W et al.(2023). "The conserved domain database in 2023.",