GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs
This family includes a group of functionally uncharacterized hypothetical proteins from archaea and their bacterial homologs. These proteins contain a putative GIY-YIG domain that shows sequence homology with bacterial UvrC DNA repair proteins. Meanwhile, all of them share a C-terminal extension with semi-conserved Cys and His residues, which suggests that the extended region may be a zinc-binding nucleic acid interaction domain. Although the majority of family members have a standalone GIY-YIG domain composition, some of them do have additional endonulcease III domain or sugar fermentation stimulation protein domain, both of which are N-terminally fused to the GIY-YIG domain. As a result, those proteins could perform some other role by cooperating with different domains, which remains to be determined in the future.
Comment:Based on similarity to the sequence of Enterobacteria phage T4 homing endonuclease I-Tevi (1LN0).
Comment:The invariant Asn residue in last conserved motif of GIY-YIG homing endonuclease I-TevI (1LN0) is substituted by Asp residue in the this family.
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