Conserved Protein Domain Family
GIY-YIG_MSH
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cd10438: GIY-YIG_MSH 
Catalytic GIY-YIG domain of eukaryotic DNA mismatch repair protein MutS homologs
This family represents a putative GIY-YIG nuclease domain C-terminally fused to the DNA-repair ATPase on a small group of eukaryotic DNA mismatch repair protein mutS homologs (MSH). The MSH proteins in this family do not have the zinc finger domain, but have a predicted mitochondrial localization. They might play roles in the recognition and repair of errors made during the replication of DNA. The prototype of this family is the protein encoded by the chloroplast mutator (CHM) locus from Arabidopsis thaliana. It is suggested that this protein could be involved in the maintenance of mitochondrial genome stability.
Links
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Statistics
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PSSM-Id: 198385
Aligned: 5 rows
Threshold Bit Score: 112.567
Created: 10-Nov-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative activeputative metalGIY-YIG
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on similarity to the sequence of Enterobacteria phage T4 homing endonuclease I-Tevi (1LN0).
  • Comment:The last conserved motif (invariant Asn residue) of GIY-YIG homing endonuclease I-TevI (1LN0) is absent in most family members.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #                  # #       #   #                            #            # 
NP_189075    1025 SCVYVMRRp---------DKRLYIGQTDDLEGRIRAHRAkeg---lqGSSFLYLMVQGksMACQLETLLINQLheQGYSL 1092 thale cress
CAL53145      989 TCVYILRRg---------DGWCYCGESDHLPTRLTSHRQstvrlielVYVAVPKEAGGksAARSLESRVIQALnlARVPL 1059 Ostreococcus ...
EFJ37424      914 SCVYILHRp---------DGKFYVGQTDNLSGRIASHRTsmg---lkQAPFLYLPVSNksVACQLETALITQLtqQGLNL 981  Selaginella m...
EED87654      884 SCVYILKIgge-----snNSMYYVGETDSLARRLSQHRAkgdq-wssLSAVAIQIEGGktSARNIESLVIQRLakSGFNL 957  Thalassiosira...
XP_002788600  474 SVVYVLALmprggggggaVQEYYVGETENLSKRLEQHRRrlee-thvITGIDCVLTRGkgEAQSIEGALIRHLqgRGARL 552  Perkinsus mar...

Feature 1           
NP_189075    1093 AN 1094 thale cress
CAL53145     1060 WS 1061 Ostreococcus tauri
EFJ37424      982 VN 983  Selaginella moellendorffii
EED87654      958 AS 959  Thalassiosira pseudonana CCMP1335
XP_002788600  553 IS 554  Perkinsus marinus ATCC 50983

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