Conserved Protein Domain Family
GHITM
?
cd10431: GHITM (This model is not part of the current CDD release)
Growth-hormone inducible transmembrane protein
GHITM appears to be ubiquitously expressed in mammalian cells and expression has also been observed in various cancer cell lines. A cytoprotective function has been suggested. It is closely related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect.
Links
?
Statistics
?
PSSM-Id: 501515
Aligned: 52 rows
Threshold Bit Score: 162.758
Created: 10-Jun-2011
Updated: 30-Oct-2024
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
NP_001026388  81 GKLVVAGGAAVGLGALCYYGMgmss------------------------eigAIERAVIWPQYVKDRIRSTYMYFAGSIG 136 chicken
XP_002675698  48 VKTLVTGGLLIGTGYLLNKTMneptqaigrygn--------tselaqqrlvqPDMARTGLNPIVQQYMSGTYKYVALNVA 119 Naegleria gruberi
CAF1175608   157 QALVRGGVALVAIGGAGYLLNkilnspttmpsg-------tltkskqvsfadAVEANRAFSSVVKGHLRSTYAHFAGGLA 229 Adineta ricciae
CEO97135      75 HAAHSGAMTLVGAGGLMVSTYlvlnh---------------------llnkrEGYSFGAIPSSVHEYMRGTYGYVLGGLG 133 Plasmodiophora ...
CCW62557      35 RFPLAKRATLAGLGGSSAFRAfttpsrpsfihvrggeirrrdtpmtwdgtpsRGSEADSLTPYVREHLTRVYTLLATGCV 114 Phytomonas sp. EM1
XP_021966928  83 GQGIVTAGLVFGSGSLLYYTLfdqddge------------------vstlvsSSGGGLYAPEFISDRINTAYMYMFNSLG 144 Folsomia candida
KNH07323      70 SKLLPTSARYMRLGGNSNRDSpiepiy-------------------spqsysGERTADDLPPHVRDHLTRTYLLLASGVA 130 Perkinsela sp. ...
XP_005787842  64 SQSQVKEAPPTAAGAPATFPSyeqr------------------------qqqAGSQYESLSDGVVAHMRRVYATLATGIG 119 Emiliania huxle...
KAG8462885    78 AEQPASQLQRPSSDQQPYYDDqrar------------------------gtaPGSQFDSVTAGVSAHLQKVYATLCAGIG 133 Diacronema lutheri
XP_013756838 175 REVVDVERGDGRYGERVEYSErd---------------------------vfTGQQADAITDDVGRYLVKVYATLGATVG 227 Thecamonas trah...

NP_001026388 137 LTALSAVAVSRSpalm---glmtKGSWLAIGATFAAMIGAGMLVRSIsyenspaAKHLAWMMHSGVMGAVVAPLAFLGGP 213 chicken
XP_002675698 120 LTTLFAVGAYKSglvf---rilnMNPWMHLLVFGGGMIGTNMITRSLdintnsaLKHTMLTAFNGIVGLSLCYVGLMYRP 196 Naegleria gruberi
CAF1175608   230 MTGAFAYVFHRNglga---rlmtMNKWAYMGVTLLGSIGTLYATMAIddqrqpaLKYGAWATFNGIMGLSLAPLCFMQPA 306 Adineta ricciae
CEO97135     134 ITAASAVVAFRQgaal---rmlqMNPWGYMGLSLASVMGGTMITMSLsstespvMKHAAWVATMAAVGAVTMSPFALVPG 210 Plasmodiophora ...
CCW62557     115 AAGLGSLLMIATpla------kvIPFWMPMVGGFIPLLWLSFAPPANp-----gLKIALFYAFTLLEGMAIAPLVLMTAA 183 Phytomonas sp. EM1
XP_021966928 145 ISTLGAAASFRFfrnpiflnaisAQPLLAIGLAMASQFAVTMLVRSLpyregfgAKQAGSIAQALLVGLSAAPLYLLGAQ 224 Folsomia candida
KNH07323     131 GAGIGASMMIFTplc------kvIPYWFPMLGAFVPLLWLNFAPPANp-----nLKLALFFSFCFLEGMAIAPIIWVSAA 199 Perkinsela sp. ...
XP_005787842 120 ISAAASVTAMATpl-------glVHPLIPGLGAMVPLLGLMYTSKHThs---qtLRAGLFAAFTGLSGWAMAPLLLVALK 189 Emiliania huxle...
KAG8462885   134 VAAGASMVSMATglaam--ipafVPGILALAPMVYLLSYTNKFTHSSe------FRTGLFVAFTALSGLAIAPLLKLFLG 205 Diacronema lutheri
XP_013756838 228 AAAGGTMLGMFTal-------gsVSPMVYALGAFVPILGVSFTRGRDvs---ptLRAAMLGTGGVLMGLSSAPLIGHFLA 297 Thecamonas trah...

NP_001026388 214 ----LLIRAAWYTAGIVGGLSTVAMCAPSEKFLNMGGPLGIGFGFVLVSSIGSMFLPPtsa-fgAGLYSVAVYGGLVLFG 288 chicken
XP_002675698 197 e---IIMRAALYTAGIFGALSYVAINAEQDKFLSMGGPLLAGLAVVFLSSLAPLVLPAtmtrtlQATEAIALYGGLLLFG 273 Naegleria gruberi
CAF1175608   307 ----LLARAALVTTGLVGSISAVGMTARREQYLWIGAPLMAGLVTVALASIGSVFLPAtairaaSLLNSISIYGGVVVFS 382 Adineta ricciae
CEO97135     211 p---ILYRAALYTAGIVGSLSLVSMNAEQGAFLYLGGPLFAGLTVVALSSISGMFLPVgga-afNIAQSLSLYGGLVVFG 286 Plasmodiophora ...
CCW62557     184 k--gVLTTSLVLTAAVFFGFSAAAYLAPRASLVAWQGPLYGALIGMVAISVLNIFYPT------AIVHSIILYGGLALFS 255 Phytomonas sp. EM1
XP_021966928 225 ----SIIRAGFVTAGLVGGLTGVSTILPHDAFAKWEIPLRIGMYTVLLSFMALWFLPRrhf-syTWLYRVAMHGGLVVFP 299 Folsomia candida
KNH07323     200 k--gVLFSALFLTFAVFAGFTAAAFLAPQGRLLAFQGPLFAILIGFIGISFLNLFFPS------KFAHSILLYGGLALFS 271 Perkinsela sp. ...
XP_005787842 190 vspaIVPQALAITTGLFGTMTALSLFAKPGSMLRLGVPLGAGMLMLLGCGVAGMFVPVtsa-wyPLLHSINLYGGLGIFT 268 Emiliania huxle...
KAG8462885   206 inptAIPLALGATAGLFGVMTLLAMMAPRGAMLKFGVPLGAGMIVLLVLSLGGIFVPVtsp-faPLLHNVMLYGGLGLFT 284 Diacronema lutheri
XP_013756838 298 vdptIVGTALMGTTAIFGGFSLMALKARRRAMLTLGGPLMGSLLAIVGIQLSTLFIDYaps-tlAVLNNVYLYGGLLAFS 376 Thecamonas trah...

NP_001026388 289 MFLLYDTQHVIKRAEtip------------yygVTKYDPINACMGIYTDTLNIFIRVATMLAGGG 341 chicken
XP_002675698 274 MFILYETQKVRMKGEnyknyvesetmrgtpnhmIQKPDYINSSISLYMDMVNIFVRLLYILGGNN 338 Naegleria gruberi
CAF1175608   383 GLVLWDTKKIIAHAEaa--------------hdQKQLSPINDALGIYLDFINLFIRILYIMDSRR 433 Adineta ricciae
CEO97135     287 GLVLYDTQVMMERGRiva-------------rtGQHPDYINESFGLYWNILNIFIRMVDILLRHQ 338 Plasmodiophora brassicae
CCW62557     256 IMISSDTQMMIERAR------------------CGAGDHVQDALRMFMNVINIFIRIAQIMGSMN 302 Phytomonas sp. EM1
XP_021966928 300 AYYLFNTKAMVRSATy-----------------SPHFDPINSSMSLYTDVLNIYGRLAFLLPPHY 347 Folsomia candida
KNH07323     272 ALVAVDTQSMIERAR------------------CGMGDHVQDAMGLFINMINIFVRIAQILRGND 318 Perkinsela sp. CCAP 1560/4
XP_005787842 269 LYIAYDTQNMINEYE------------------MGEDDHLKHAVDLFINFKVIFQRVLLLLMGRS 315 Emiliania huxleyi CCMP1516
KAG8462885   285 LYIAYDTQTMIAEYE------------------MGEDDHLRHAINLFINFQAIFTRLLIIFGMRN 331 Diacronema lutheri
XP_013756838 377 GFIGYDTQRMIESAR------------------DGHKDHIDDALGMFLNLRGVFMMLLQILGRRD 423 Thecamonas trahens ATCC 50062
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap