Conserved Protein Domain Family
LFG-like
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cd10428: LFG-like (This model is not part of the current CDD release)
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.
Links
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Statistics
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PSSM-Id: 501512
Aligned: 126 rows
Threshold Bit Score: 159.917
Created: 30-Oct-2024
Updated: 30-Oct-2024
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9BWQ8         92 SWDDQKVRRVFVRKVYTILLIQLLVTLAVVALFTFCDPVKDYVq--ANPGWYWASYAVFFATYLTLACCsgprrhFPWNL 169  human
XP_002367585  122 PDVDRAIRHAFVRKVYVILSIQVLFTFGVAAAFTLVDPMRTWLr--LNSWCPVAFSFAGLILMIFVTCFpdlgrrVPLNF 199  Toxoplasma go...
XP_022591240   21 ALFRKEIRHGFIRKVYGIISAQLLLTTVVTSLLLFIPGGTSWAk-qSSGSVIIASTVLMLISSLVLMCTtar-mrYPYNY 98   Cyclospora ca...
CEM04603      125 GEMPIEIRHAFIRKVYAILSFQLLLTFAIAALFFIEGSKQWLL---KNPWLFILALILMFASLITLSCCegpartYPTNY 201  Vitrella bras...
XP_018635610   43 RIFTKEIRQGFIRKVYAIIAMQLILTAAVTSLFLFVDPIRTWFl-lHGQPVFIVATVVLFATTIPLLCCdgvlrrFPYNY 121  Toxoplasma go...
XP_011133418  137 SDVDIKIRNGFVRKVYGILSFQLLVTFGMAAAFNVYRPAAVWLy--DHWWIMIVATIVYCAAVCTITCVpraarsSPTNY 214  Gregarina nip...
OLP89856       34 GMQSTAVKNGFVRKVYSILTVQLIVTTLIAAPIANYGLEMKVKspeIVSTMMFLSLAAVIAIMCVFTCCphtmreYPTNY 113  Symbiodinium ...
CEM37986       36 DDVHTTIRHGFIRKVYGILSVQLLITTVMAACLCTDAAKLFIAk--NAAILWVAMAVQLVLTFVMMCFSglm-rqFPTNY 112  Vitrella bras...
XP_002788273   51 PDTSKNVRNNFIRKVYGILCAQLVITSLIAFPFVYGKDDWAMDfvnDYVWVLWLSMAVMFATLIVLVCVpaasqkVPINY 130  Perkinsus mar...
OLP97585       40 VDVRMGHLDRFIRKVYGILGAQMVVTTIIASLITIYGEHLATAl-dEFFGLSCKSIDTMDKGHVDQLDTqh--vlQCVAL 116  Symbiodinium ...

Q9BWQ8        170 ILLTVFTLSMAYLTGMLSSYYNTT------SVLLCLGITALVCLSVTVFSFQTKFDFTSCQGVLFVLLMTLFFSGLILAI 243  human
XP_002367585  200 ILLSLITGCFSMMIAFGGAATESD------AFFLAVGITFVVVLALTVFACQTKIDFTGCGPYILVAMICLMMFGIFCIF 273  Toxoplasma go...
XP_022591240   99 LLLLVFTCSEAMLVAVVSAFYAAS------SVAFALGATVVITVGLSLFACQTKHDFTSCMGVMFVLTLNLVLFGLLALF 172  Cyclospora ca...
CEM04603      202 LLLFLFTGCEGLFIGVTTMQYDIP------AIAIAVASTGAVFCACTVFAIQTKIDFTGKGGYLFVGLIVLFIFSFIIPF 275  Vitrella bras...
XP_018635610  122 LLLCAFTLAESILVAGVTAHYSEK------TVLIAVAGTAVITIGLSLFACQVKYDFTSWVGVLFILTLNLMIFGIFCIF 195  Toxoplasma go...
XP_011133418  215 ILLSVIAVAMGLVLGFCTGAVDTF------AFSLAVGMTTAVTIAVSLFACQTKWDFTGCGIYAFVALIVLTGFGIGSIF 288  Gregarina nip...
OLP89856      114 FLLGMFTVAEAVMVGFVCANYTAQ------SVIMCLAITAVCVGGLTLFACQTKYDFTGFLPYLMTATLVLCGFSFLLMM 187  Symbiodinium ...
CEM37986      113 ILLGVWTAVEGLLVGSICAFTDPQ------LVLVAAALTTGIVLSLTLFAFQTKYDFTGIGPYLFVCCIALFLTGLVLMI 186  Vitrella bras...
XP_002788273  131 ILLFIFTASMGLMIGFIGVYYDTE------AVLIAAGSTAAAVFVLTLFAFFVKTDFTGYGPFALVLLMVLVFMGLVMIF 204  Perkinsus mar...
OLP97585      117 AMLLCFTVAESVMVGFICVQYTVQsvlvtlGITAPRCGKAALVLALSLFALQTTPLRGMYGRRYDFTGFMPYLFALVCSL 196  Symbiodinium ...

Q9BWQ8        244 Llpf-----qyvPWLHAVYAALGAGVFTLFLALDTQLLMGNRrh---sLSPEEYIFGALNIYLDIIYIFTFFLQLFGT 313  human
XP_002367585  274 Wy---------nRVANLIYASLASLLFSFLLVYDTQQVVGGKhrk-fqYSIDDYIFAALSLYMDIIGLFMNILSLLSN 341  Toxoplasma gond...
XP_022591240  173 Lg----------TWAQVLYSSLALLVFSFYLVIDTQLIIGRGql---rLEEDDYIVAAVMIYLDIINIFLTLLRLFGE 237  Cyclospora caye...
CEM04603      276 Fpn--------vQLAQKIYAGLGTLLFSMYLVYDTQLIVGGKhrr-hqFSIDDYVFASLMLYIDIIQIFIFLLSLIGS 344  Vitrella brassi...
XP_018635610  196 Lp----------KWAQVLYSSLALLLFSIYLVVDTQLLVGRGkl---rLSEDDYIVAALMIYVDIITIFLQLLRLVAA 260  Toxoplasma gond...
XP_011133418  289 Fy---------nRIYELVYSSLGAVLFSFYLVMDTQKIVGGKhra-yqFSIDDYCFAAVTLYIDIINLFMYILQIIAA 356  Gregarina nipha...
OLP89856      188 TamlggagggffRAANLVYAALGALLFCGYIVVDTQMIIGGKhst-ysFTVDDYCMAAITLYVDIIQLFLYLLQLFGV 264  Symbiodinium mi...
CEM37986      187 Msacg----lhfKWAHIIYAGLGVLLFSIYLVYDTQLIVGKKhyr-faFSVDDYCFAALMLYIDIIQIFLYILSILRE 259  Vitrella brassi...
XP_002788273  205 Lpt--------nRYLQIVYGSIGALVFSIYLVIDTQMIVGGKnrr-tqLGVDQYITGALMLYMDIINLFLFVLTIVGA 273  Perkinsus marin...
OLP97585      197 Clfgl---vmsiFAWNMIYAGLGAVIFSFYIIFDTQLIVGGKhnkfrfSIDDYCMAAAINIYVDIIQLFLFLLQLLGD 271  Symbiodinium mi...
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