Conserved Protein Domain Family
SH2_Jak2

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cd10379: SH2_Jak2 
Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
Jak2 is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constitutively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.
Statistics
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PSSM-Id: 198242
Aligned: 6 rows
Threshold Bit Score: 185.768
Created: 18-May-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
phosphotyrosinehydrophobic
Feature 1:phosphotyrosine binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                             #                   #                        # #            
2499669       386 EVAPPAVLENIHSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLS 465  Norway rat
ABD73285      370 DVAPPYLLEAIESYCHGPISMDFAISKLRKSGNQKGLFVLRCSPKDYNKYFLTLAFGGYGNVEYKHCLITRSESGNYNLS 449  zebrafish
Q75R65        384 EVAPPSVLENIQSNCHGPIFMDFAINKLKKAGNQTGFYVLRCSPKDFKKYFLTFAIERENATDYKHCLITKNENGEYNLS 463  chicken
3687398       352 EVAPPRLLEAIQINCHGPLSTEFAVSRLRRCEGQPGVYILRCSPKDYDRYFLSFMVEAEGQLELKHCLVLRSLSGEFVLS 431  zebrafish
AAO47335      389 EVAPPRLLECLQSYCHGPLSMEFTLSKLRCYGNYQGLYILRCSPRDYDKYYMSFVVGHEGALDYKHCQIVKTEAGHFLLS 468  green pufferfish
NP_001085288  384 EVVPPRLLEGIQSYCHGPVSMEFAINKLKKAGNQRGLFILRCSPKEFNKYFLTFSIERDGVIEYKHCLITKNDNGDYNLS 463  African clawe...
Feature 1                          
2499669       466 GTKRNFSSLKDLLNCYQ 482  Norway rat
ABD73285      450 GTKKSFRSLQDLLKCYQ 466  zebrafish
Q75R65        464 GTKRSFGNLKDLLTCYQ 480  chicken
3687398       432 GARCSFSSLSELLARYQ 448  zebrafish
AAO47335      469 GAKKSYGSIRDLLHCYR 485  green pufferfish
NP_001085288  464 GAKKSFATLKDLLNCYQ 480  African clawed frog

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